PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21621526-6	2011	Cyp1a1 expression was directly related to the level of NO production and to reduced arsenic cytotoxicity.	Arsenic	84-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6	
26535918-5	2015	Arsenic inhibited CYP1A1 enzyme activity and reduced the metabolic clearance of FICZ.	Arsenic	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	18-24	
26535918-6	2015	Arsenic also led to activated CYP1A1 transcription but only in cells grown in medium containing trace amounts of the endogenous ligand FICZ, pointing to an indirect mechanism of activation.	Arsenic	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36	
24161444-9	2014	In conclusion, this study demonstrates for the first time that methylated pentavalent arsenic metabolites are bifunctional inducers, as they increase CYP1A1 by activating the AhR/XRE signaling pathway and they increase NQO1 by activating the Nrf2/ARE signaling pathway in addition to the AhR/XRE pathway.	Arsenic	86-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	150-156	
26988683-0	2016	[Relationship of blood aryl hydrocarbon receptor mRNA and cytochrome P450 1A1 mRNA expression with corrected QT interval among residents exposed to arsenic via drinking water].	Arsenic	148-155	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-77	
26988683-9	2016	CONCLUSIONS: Long-term exposure to arsenic is associated with upregulated blood AhRmRNA and CYP1A1 mRNA expression.Blood CYP1A1 mRNA expression, but not AhRmRNA expression, is associated with prolonged corrected QT interval.	Arsenic	35-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	92-98	
26988683-9	2016	CONCLUSIONS: Long-term exposure to arsenic is associated with upregulated blood AhRmRNA and CYP1A1 mRNA expression.Blood CYP1A1 mRNA expression, but not AhRmRNA expression, is associated with prolonged corrected QT interval.	Arsenic	35-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-127	
24161444-0	2014	Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms.	Arsenic	23-30	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	85-104	
19033395-10	2009	Our findings provided clear evidence that arsenic can enhance CYP1A1 expression and activity via AhR activation, and the arsenic-induced AhR activation is probably triggered by oxidative stress.	Arsenic	42-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	62-68	
19416086-7	2009	In this review, we shed light on the effect of seven heavy metals, namely arsenic, mercury, lead, cadmium, chromium, copper and vanadium, on CYP1A1 and the consequences on drug metabolism.	Arsenic	74-81	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	141-147	
19033395-0	2009	Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study.	Arsenic	152-159	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	92-98	
19033395-5	2009	However, the effects of arsenic on cytochrome P450 1A1 (CYP1A1) status (expression and activity), which is essential for B[a]P metabolism, either in lung cells or in lung tissues, are never demonstrated.	Arsenic	24-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	35-54	
19033395-5	2009	However, the effects of arsenic on cytochrome P450 1A1 (CYP1A1) status (expression and activity), which is essential for B[a]P metabolism, either in lung cells or in lung tissues, are never demonstrated.	Arsenic	24-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62	
19033395-6	2009	We hypothesized that arsenic would enhance aryl hydrocarbon receptor (AhR) activation leading to CYP1A1 expression and activity in lung cells.	Arsenic	21-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-103	
19033395-7	2009	Indeed, our present study successfully demonstrated the elevation of CYP1A1 messenger RNA expression in H1355 cells, a human lung adenocarcinoma cell line, as well as CYP1A1 expression and activity in lung tissues of arsenic-exposed mice.	Arsenic	217-224	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	167-173	
19033395-8	2009	We further demonstrated that this elevation of CYP1A1 expression could be effectively blocked with AhR antagonist, 3",4"-dimethoxyflavone, indicating that the arsenic-induced CYP1A1 expression and activity were via AhR activation.	Arsenic	159-166	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-53	
19033395-8	2009	We further demonstrated that this elevation of CYP1A1 expression could be effectively blocked with AhR antagonist, 3",4"-dimethoxyflavone, indicating that the arsenic-induced CYP1A1 expression and activity were via AhR activation.	Arsenic	159-166	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	175-181	
19033395-9	2009	Furthermore, we found that arsenic-induced AhR activation and -enhanced CYP1A1 expression can be further increased by a prooxidant, buthionine-(S,R)-sulfoximine, and suppressed by antioxidants, such as N-acetylcysteine and catalase.	Arsenic	27-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-78	
16713074-0	2006	Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells.	Arsenic	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-49	
16713074-6	2006	In the present study, we demonstrated that arsenic not only inhibited the TCDD-induced CYP1A1 activation but also interfered with DRE-CALUX bioassay in human hepatoma cells.	Arsenic	43-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93	
11162773-2	2001	The effect of As, Pb, Hg, or Cd (ranked as the most hazardous environmental metals by EPA and ATSDR) on CYP1A1 and 1A2 induction by benzo[a]pyrene (BaP), benzo[b]fluoranthene (BbF), dibenzo[a,h]anthracene (DBahA), benzo[a]anthracene (BaA), and benzo[k]fluoranthene (BkF) has thus been investigated in fresh human hepatocyte cultures.	Arsenic	14-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110	
16099114-9	2005	In this work we demonstrate that genetic biomarkers such as CYP1A1 2A and GSTM1 polymorphisms in addition to DR70 as screening biomarkers might provide relevant information to identify individuals with higher risk for lung cancer, due to arsenic exposure.	Arsenic	238-245	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	60-66	
16274885-10	2005	Our data clearly show that As(3+)-, Cd(2+)-, and Cr(6+)-induced oxidative stress modulates Cyp1a1 at transcriptional and posttranscriptional levels but induces Nqo1 and Gst ya at the transcriptional level.	Arsenic	27-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	91-97	
16012082-0	2005	CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water.	Arsenic	77-84	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6	
32417511-2	2020	The transformation follows the route of "dissolution-recrystallization", during which the arsenic pollutant in gypsum is released into the solution, and hence raises the possibility of being distributed into the product of alpha-HH, a potential harm that has always been neglected.	Arsenic	90-97	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	223-231	
28189647-13	2017	This modulation of CYP1A1 proves that trivalent metabolites of arsenic are highly reactive and could participate in arsenic toxicity.	Arsenic	63-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	19-25