PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27427241-7 2016 The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses. Arsenic 43-45 C-X-C motif chemokine ligand 8 Homo sapiens 136-141 31313790-5 2019 Exposure to As(iii) and As(v) generates an increase in the release of the pro-inflammatory cytokine IL-8 (57-1135%) and an increase in the generation of reactive oxygen and/or nitrogen species (130-340%) in both cell lines. Arsenic 12-14 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 22883023-8 2012 Serum levels of IL6 and IL8 also increased in the arsenic exposed group. Arsenic 50-57 C-X-C motif chemokine ligand 8 Homo sapiens 24-27 26008221-0 2015 Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. Arsenic 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 52-56 26008221-3 2015 In this work, we have studied the effect of arsenic exposure on renal system using human embryonic kidney cells and prenatally exposed animals and identified Interleukin-8(IL-8) and its homologue (CINC-1) as mediators of arsenic induced renal toxicity. Arsenic 221-228 C-X-C motif chemokine ligand 8 Homo sapiens 158-171 26008221-3 2015 In this work, we have studied the effect of arsenic exposure on renal system using human embryonic kidney cells and prenatally exposed animals and identified Interleukin-8(IL-8) and its homologue (CINC-1) as mediators of arsenic induced renal toxicity. Arsenic 221-228 C-X-C motif chemokine ligand 8 Homo sapiens 172-176 26008221-4 2015 We further show that embryonic kidney cells are more responsive to arsenic leading to higher induction of IL-8 as compared to adult cells due to DNA methylation and histone acetylation (H3 acetylation) changes in the IL-8 promoter. Arsenic 67-74 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 26008221-4 2015 We further show that embryonic kidney cells are more responsive to arsenic leading to higher induction of IL-8 as compared to adult cells due to DNA methylation and histone acetylation (H3 acetylation) changes in the IL-8 promoter. Arsenic 67-74 C-X-C motif chemokine ligand 8 Homo sapiens 217-221 26008221-5 2015 Through bisulfite analysis of the IL-8 promoter, we have also identified an arsenic modulated CpG site at -168 bases upstream of transcription start site. Arsenic 76-83 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 26008221-6 2015 This CpG is associated with C/EBP and CREB binding sites in the IL-8 promoter and its demethylation by arsenic coupled with increased H3 histone acetylation and CBP/P300 recruitment could lead to induction of IL-8. Arsenic 103-110 C-X-C motif chemokine ligand 8 Homo sapiens 64-68 26008221-6 2015 This CpG is associated with C/EBP and CREB binding sites in the IL-8 promoter and its demethylation by arsenic coupled with increased H3 histone acetylation and CBP/P300 recruitment could lead to induction of IL-8. Arsenic 103-110 C-X-C motif chemokine ligand 8 Homo sapiens 209-213 26008221-7 2015 Our study shows how epigenetic modulation of IL-8 by arsenic could contribute to increased cell migratory and proliferative capabilities, cell cycle dysregulation and renal toxicity. Arsenic 53-60 C-X-C motif chemokine ligand 8 Homo sapiens 45-49 23727622-1 2013 Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8). Arsenic 20-27 C-X-C motif chemokine ligand 8 Homo sapiens 194-207 23727622-1 2013 Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8). Arsenic 20-27 C-X-C motif chemokine ligand 8 Homo sapiens 209-213 23727622-10 2013 The present results also showed a significant increase in UC risk in subjects with the IL-8 -251 T/T genotype for each SD increase in urinary total arsenic and MMA%. Arsenic 148-155 C-X-C motif chemokine ligand 8 Homo sapiens 87-91 25257954-3 2014 We found the concentrations of IL-8, TNF-alpha, and TGF-alpha presented in urine were significantly elevated in the high urinary arsenic workers compared with the low urinary arsenic workers. Arsenic 129-136 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 25257954-8 2014 These data indicated that arsenic increased the secretion of inflammatory factors and IL-8, TNF-alpha, and TGF-alpha expression may be a useful biomarker of the effect of arsenic exposure. Arsenic 26-33 C-X-C motif chemokine ligand 8 Homo sapiens 86-90 25257954-8 2014 These data indicated that arsenic increased the secretion of inflammatory factors and IL-8, TNF-alpha, and TGF-alpha expression may be a useful biomarker of the effect of arsenic exposure. Arsenic 171-178 C-X-C motif chemokine ligand 8 Homo sapiens 86-90 34609586-10 2022 In the exposed group a positive correlation between serum copper, arsenic and serum ICAM and IL8 was found. Arsenic 66-73 C-X-C motif chemokine ligand 8 Homo sapiens 93-96 21777978-0 2011 Arsenic increases lipopolysaccharide-dependent expression of interleukin-8 gene by stimulating a redox-sensitive pathway that strengthens p38-kinase activation. Arsenic 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 61-74 19349368-5 2009 Incubating human microvascular endothelial cells with the sphingosine-1-phosphate type 1 receptor (S1P(1)) inhibitor VPC23019 or performing small interfering RNA knockdown of S1P(1) blocked arsenic-stimulated HMVEC angiogenic gene expression and tube formation, but did not affect induction of either HMOX1 or IL8. Arsenic 190-197 C-X-C motif chemokine ligand 8 Homo sapiens 310-313 18767879-2 2008 The experimental results indicate that addition of NaF, NaCl, NaHCO 3, or NaNO 3 can result in phase inversion of ATPS-C formed by 12-3-12/AS systems; however, addition of NaBr cannot lead to phase inversion. Arsenic 139-141 C-X-C motif chemokine ligand 8 Homo sapiens 51-54 22469443-6 2012 RESULTS: Serum levels of IL-8, MCP-1, and CCL-20 were significantly higher in the AS group than in the AR and NA groups. Arsenic 82-84 C-X-C motif chemokine ligand 8 Homo sapiens 25-29 10775461-2 2000 Here, we investigated whether arsenic, which has been shown to inhibit the ubiquitin-proteasome pathway, could inhibit TNF-alpha-mediated increases in IL-8 expression. Arsenic 30-37 C-X-C motif chemokine ligand 8 Homo sapiens 151-155 9728050-7 1998 The same acute exposure to As, V, or Zn that activated MAPK was sufficient to induce a subsequent increase in IL-8 protein expression in BEAS cells. Arsenic 27-29 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 8931876-0 1996 Arsenic induces interleukin-8 expression in cultured keratinocytes. Arsenic 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 16-29 34609586-13 2022 CONCLUSION: Occupational exposure to copper and arsenic was associated with ventilatory and radiological impairment, with a corresponding increase in the serum level of ICAM-1 and IL8, which can be used as biomarkers for pulmonary impairment among copper smelter workers. Arsenic 48-55 C-X-C motif chemokine ligand 8 Homo sapiens 180-183 35241635-0 2022 Human endothelial cells promote arsenic-transformed lung epithelial cells to induce tumor growth and angiogenesis through interleukin-8 induction. Arsenic 32-39 C-X-C motif chemokine ligand 8 Homo sapiens 122-135 33396024-0 2021 HER2 overexpression triggers the IL-8 to promote arsenic-induced EMT and stem cell-like phenotypes in human bladder epithelial cells. Arsenic 49-56 C-X-C motif chemokine ligand 8 Homo sapiens 33-37 33396024-6 2021 Phosphorylation of the human epidermal growth factor receptor 2 (HER2) was key for arsenic-induced IL-8 overexpression and depended on the simultaneous activation of the MAPK, JNK, PI3K/AKT and GSK3beta signaling pathways. Arsenic 83-90 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 33396024-8 2021 These results demonstrate that the HER2/IL-8 axis is related to the acquisition of an EMT phenotype and CSCs in arsenic-treated cells. Arsenic 112-119 C-X-C motif chemokine ligand 8 Homo sapiens 40-44