PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32519707-10	2020	Moreover, the overexpression of transcription factor EB (TFEB), the master transcriptional regulator of autophagy and lysosome biogenesis, partially relieved arsenic-inhibited lysosomal CTSD and CTSL expressions, recovered the disorder of autophagic flux, promoted the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-12, and reduced anti-inflammatory cytokine IL-10 secretion.	Arsenic	158-165	interleukin 1 alpha	Homo sapiens	321-329	
22178533-14	2012	Subsequent pathway analysis further revealed a gene network involving interleukin 1-alpha (IL1A) in mediating the arsenic-resistant phenotype.	Arsenic	114-121	interleukin 1 alpha	Homo sapiens	70-89	
22178533-14	2012	Subsequent pathway analysis further revealed a gene network involving interleukin 1-alpha (IL1A) in mediating the arsenic-resistant phenotype.	Arsenic	114-121	interleukin 1 alpha	Homo sapiens	91-95	
19787300-7	2009	The chronic exposure to arsenic upregulates the expression of tumor necrosis factor-alpha, interleukin-1, vascular cell adhesion molecule and vascular endothelial growth factor to induce cardiovascular pathogenesis.	Arsenic	24-31	interleukin 1 alpha	Homo sapiens	91-104	
34229406-0	2021	Microglia-derived IL-1beta promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2alpha/ATF4/CHOP upon arsenic exposure.	Arsenic	130-137	interleukin 1 alpha	Homo sapiens	18-26	
34229406-5	2021	Our findings demonstrated that arsenic-induced cognitive dysfunction, microglia activation, up-regulation and release of IL-1beta and ER stress-mediated apoptosis could be attenuated by minocycline, a recognized inhibitor of microglia activation.	Arsenic	31-38	interleukin 1 alpha	Homo sapiens	121-129	
31734849-10	2020	Arsenic could also trigger the induction of GATA4-NF-kappaB signaling and senescence-associated secretory phenotype (SASP) by increasing IL-1alpha, IL-1beta, TGF-beta, TNF-alpha, CCL2, PAI-1, and MMP13 mRNA expression.	Arsenic	0-7	interleukin 1 alpha	Homo sapiens	137-146