PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22178533-14 2012 Subsequent pathway analysis further revealed a gene network involving interleukin 1-alpha (IL1A) in mediating the arsenic-resistant phenotype. Arsenic 114-121 interleukin 1 alpha Homo sapiens 70-89 22178533-14 2012 Subsequent pathway analysis further revealed a gene network involving interleukin 1-alpha (IL1A) in mediating the arsenic-resistant phenotype. Arsenic 114-121 interleukin 1 alpha Homo sapiens 91-95 19787300-7 2009 The chronic exposure to arsenic upregulates the expression of tumor necrosis factor-alpha, interleukin-1, vascular cell adhesion molecule and vascular endothelial growth factor to induce cardiovascular pathogenesis. Arsenic 24-31 interleukin 1 alpha Homo sapiens 91-104 34229406-0 2021 Microglia-derived IL-1beta promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2alpha/ATF4/CHOP upon arsenic exposure. Arsenic 130-137 interleukin 1 alpha Homo sapiens 18-26 34229406-5 2021 Our findings demonstrated that arsenic-induced cognitive dysfunction, microglia activation, up-regulation and release of IL-1beta and ER stress-mediated apoptosis could be attenuated by minocycline, a recognized inhibitor of microglia activation. Arsenic 31-38 interleukin 1 alpha Homo sapiens 121-129 32519707-10 2020 Moreover, the overexpression of transcription factor EB (TFEB), the master transcriptional regulator of autophagy and lysosome biogenesis, partially relieved arsenic-inhibited lysosomal CTSD and CTSL expressions, recovered the disorder of autophagic flux, promoted the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-12, and reduced anti-inflammatory cytokine IL-10 secretion. Arsenic 158-165 interleukin 1 alpha Homo sapiens 321-329 31734849-10 2020 Arsenic could also trigger the induction of GATA4-NF-kappaB signaling and senescence-associated secretory phenotype (SASP) by increasing IL-1alpha, IL-1beta, TGF-beta, TNF-alpha, CCL2, PAI-1, and MMP13 mRNA expression. Arsenic 0-7 interleukin 1 alpha Homo sapiens 137-146