PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33894237-1 2021 Methylation of arsenic compounds in the human body occurs following a series of biochemical reactions in the presence of methyl donor S-adenosylmethionine (SAM) and catalyzed by arsenite methyltransferase (AS3MT). Arsenic 15-22 arsenite methyltransferase Homo sapiens 206-211 16841956-0 2006 shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells. Arsenic 46-53 arsenite methyltransferase Homo sapiens 19-24 16407288-12 2006 These results raise the possibility that inherited variation in AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans. Arsenic 101-108 arsenite methyltransferase Homo sapiens 64-69 16407288-12 2006 These results raise the possibility that inherited variation in AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans. Arsenic 134-141 arsenite methyltransferase Homo sapiens 64-69 15526190-0 2005 A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19. Arsenic 37-44 arsenite methyltransferase Homo sapiens 100-123 15526190-1 2005 The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). Arsenic 18-25 arsenite methyltransferase Homo sapiens 163-168 15526190-6 2005 Human recombinant Cyt19 catalyzed transfer of a methyl group from S-adenosyl-L-methionine to arsenic and produced monomethyl and dimethyl arsenicals. Arsenic 93-100 arsenite methyltransferase Homo sapiens 18-23 15526190-7 2005 The methylation of arsenic was catalyzed by Cyt19 only when ATG was present in the reaction mixture. Arsenic 19-26 arsenite methyltransferase Homo sapiens 44-49 10328340-1 1999 Biotransformation of inorganic arsenic in mammals is catalyzed by three serial enzyme activities: arsenate reductase, arsenite methyltransferase, and monomethylarsonate methyltransferase. Arsenic 31-38 arsenite methyltransferase Homo sapiens 118-186 34899152-3 2021 Arsenite methyltransferase (AS3MT) catalyzes the biomethylation of arsenic and hence regulates arsenic metabolism. Arsenic 67-74 arsenite methyltransferase Homo sapiens 0-26 34899152-3 2021 Arsenite methyltransferase (AS3MT) catalyzes the biomethylation of arsenic and hence regulates arsenic metabolism. Arsenic 67-74 arsenite methyltransferase Homo sapiens 28-33 34899152-3 2021 Arsenite methyltransferase (AS3MT) catalyzes the biomethylation of arsenic and hence regulates arsenic metabolism. Arsenic 95-102 arsenite methyltransferase Homo sapiens 0-26 34899152-3 2021 Arsenite methyltransferase (AS3MT) catalyzes the biomethylation of arsenic and hence regulates arsenic metabolism. Arsenic 95-102 arsenite methyltransferase Homo sapiens 28-33 35490756-8 2022 Moreover, our analyses revealed associations between AS3MT variants and the fraction of mono-methylated arsenic in urine and showed that the Bolivian study groups had the highest frequency of alleles associated with more efficient arsenic metabolism reported so far. Arsenic 104-111 arsenite methyltransferase Homo sapiens 53-58 15929903-7 2005 The existence of a strong, developmentally regulated genetic association between CYT19 and arsenic metabolism carries import for both arsenic pharmacogenetics and arsenic toxicology, as well as for public health and governmental regulatory officials. Arsenic 91-98 arsenite methyltransferase Homo sapiens 81-86 15929903-7 2005 The existence of a strong, developmentally regulated genetic association between CYT19 and arsenic metabolism carries import for both arsenic pharmacogenetics and arsenic toxicology, as well as for public health and governmental regulatory officials. Arsenic 134-141 arsenite methyltransferase Homo sapiens 81-86 15929903-7 2005 The existence of a strong, developmentally regulated genetic association between CYT19 and arsenic metabolism carries import for both arsenic pharmacogenetics and arsenic toxicology, as well as for public health and governmental regulatory officials. Arsenic 134-141 arsenite methyltransferase Homo sapiens 81-86 33768354-7 2021 These adverse health effects are in part associated with the production of methylated trivalent arsenic species, methylarsonous acid (MAsIII) and dimethylarsinous acid (DMAsIII), during AS3MT-catalyzed methylation of iAs. Arsenic 96-103 arsenite methyltransferase Homo sapiens 186-191 34730462-0 2021 Polymorphisms of the AS3MT gene are associated with arsenic methylation capacity and damage to the P21 gene in arsenic trioxide plant workers. Arsenic 52-59 arsenite methyltransferase Homo sapiens 21-26 34730462-2 2021 The arsenite methyltransferase (AS3MT) gene plays a key role in As metabolism. Arsenic 64-66 arsenite methyltransferase Homo sapiens 32-37 34730462-15 2021 Our results suggest that rs1191454 and rs7085104 in the AS3MT gene affect the As-induced DNA damage by altering individual metabolic efficiency. Arsenic 78-80 arsenite methyltransferase Homo sapiens 56-61 35226250-7 2022 Furthermore, we demonstrated that arsenite methyltransferase (AS3MT), an essential enzyme in arsenic metabolic processes, interacted with NLRP3 to activate the inflammasome, thereby contributing to arsenic-induced hepatic IR. Arsenic 93-100 arsenite methyltransferase Homo sapiens 62-67 35226250-7 2022 Furthermore, we demonstrated that arsenite methyltransferase (AS3MT), an essential enzyme in arsenic metabolic processes, interacted with NLRP3 to activate the inflammasome, thereby contributing to arsenic-induced hepatic IR. Arsenic 198-205 arsenite methyltransferase Homo sapiens 62-67 35226250-9 2022 In summary, we showed that AS3MT-induced m6A modification critically regulated NLRP3 inflammasome activation during arsenic-induced hepatic IR, and we identified a novel post-transcriptional function of AS3MT in promoting arsenicosis. Arsenic 116-123 arsenite methyltransferase Homo sapiens 203-208 35051766-7 2022 Efficiency of arsenic metabolism was evaluated by a polymorphism (rs3740393) in the main arsenic methylating gene AS3MT measured by TaqMan allelic discrimination, and by the relative fractions of urinary inorganic arsenic metabolites. Arsenic 14-21 arsenite methyltransferase Homo sapiens 114-119 33894237-11 2021 These along with epigenetic down-regulation of AS3MT may be responsible for higher susceptibility in arsenic exposed individuals. Arsenic 101-108 arsenite methyltransferase Homo sapiens 47-52 33340130-5 2021 Polymorphism in As3MT, MRP1, and P-gp modified the arsenic metabolism increasing significantly the AsV urinary levels. Arsenic 51-58 arsenite methyltransferase Homo sapiens 16-21 33956289-0 2021 Regulation of arsenic methylation: identification of the transcriptional region of the human AS3MT gene. Arsenic 14-21 arsenite methyltransferase Homo sapiens 93-98 33956289-1 2021 The human enzyme As(III) S-adenosylmethionine methyltransferase (AS3MT) catalyzes arsenic biotransformations and is considered to contribute to arsenic-related diseases. Arsenic 82-89 arsenite methyltransferase Homo sapiens 65-70 33956289-1 2021 The human enzyme As(III) S-adenosylmethionine methyltransferase (AS3MT) catalyzes arsenic biotransformations and is considered to contribute to arsenic-related diseases. Arsenic 144-151 arsenite methyltransferase Homo sapiens 65-70 33826413-1 2021 BACKGROUND: Common genetic variation in the arsenic methyltransferase (AS3MT) gene region is known to be associated with arsenic metabolism efficiency (AME), measured as the percentage of dimethylarsinic acid (DMA%) in the urine. Arsenic 44-51 arsenite methyltransferase Homo sapiens 71-76 33826413-4 2021 METHODS: We generated targeted DNA sequencing data for the coding regions of AS3MT for three arsenic-exposed cohorts with existing data on arsenic species measured in urine: Health Effects of Arsenic Longitudinal Study (HEALS, n=2,434), Strong Heart Study (SHS, n=868), and New Hampshire Skin Cancer Study (NHSCS, n=666). Arsenic 93-100 arsenite methyltransferase Homo sapiens 77-82 33826413-4 2021 METHODS: We generated targeted DNA sequencing data for the coding regions of AS3MT for three arsenic-exposed cohorts with existing data on arsenic species measured in urine: Health Effects of Arsenic Longitudinal Study (HEALS, n=2,434), Strong Heart Study (SHS, n=868), and New Hampshire Skin Cancer Study (NHSCS, n=666). Arsenic 139-146 arsenite methyltransferase Homo sapiens 77-82 33826413-4 2021 METHODS: We generated targeted DNA sequencing data for the coding regions of AS3MT for three arsenic-exposed cohorts with existing data on arsenic species measured in urine: Health Effects of Arsenic Longitudinal Study (HEALS, n=2,434), Strong Heart Study (SHS, n=868), and New Hampshire Skin Cancer Study (NHSCS, n=666). Arsenic 192-199 arsenite methyltransferase Homo sapiens 77-82 33737636-8 2021 Again, adjusted analysis showed significant association of AA genotype of AS3MT rs10748835 with CVD patients from arsenic affected areas. Arsenic 114-121 arsenite methyltransferase Homo sapiens 74-79 32930475-3 2021 In this study, we found that the AS3MT was overexpressed in arsenic exposed population, non-small cell lung cancer (NSCLC) tissues, and A549 cells with sodium arsenite (NaAsO2 ) treatment for 48 hours. Arsenic 60-67 arsenite methyltransferase Homo sapiens 33-38 32930475-4 2021 Besides, the level of AS3MT expression was positively correlated with the concentrations of urinary total arsenic (tAs), inorganic arsenic (iAs), methanearsonic acid (MMA), and dimethylarsinic acid (DMA) in all subjects. Arsenic 106-113 arsenite methyltransferase Homo sapiens 22-27 33340130-0 2021 Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1, and P-gp) with lung cancer in a Mexican cohort. Arsenic 94-101 arsenite methyltransferase Homo sapiens 103-108 33340130-3 2021 Among the risk factors for cancer, arsenic methylation efficiency (As3MT) and the clearance of arsenic from cells by two members of the ATP-binding cassette (ABC) transporter family (multidrug resistance protein 1 [MRP1] and P-glycoprotein [P-gp]) play an important role in processing of arsenic and decreasing its intracellular levels. Arsenic 35-42 arsenite methyltransferase Homo sapiens 67-72 33549147-6 2021 Eighteen single nucleotide polymorphisms (SNPs) of the arsenic (+ 3 oxidative state) methylation transferase (AS3MT) gene, which was known as the main catalyzer for arsenic methylation, were tested with the polymerase chain reaction method. Arsenic 55-62 arsenite methyltransferase Homo sapiens 110-115 33549147-6 2021 Eighteen single nucleotide polymorphisms (SNPs) of the arsenic (+ 3 oxidative state) methylation transferase (AS3MT) gene, which was known as the main catalyzer for arsenic methylation, were tested with the polymerase chain reaction method. Arsenic 165-172 arsenite methyltransferase Homo sapiens 110-115 32930475-7 2021 Therefore, arsenic increased AS3MT expression in vivo and in vitro, which could directly act on the cell and affect the progression of NSCLC by regulating cell cycle genes. Arsenic 11-18 arsenite methyltransferase Homo sapiens 29-34 33156617-0 2020 Predicted AS3MT Proteins Methylate Arsenic and Support Two Major Phylogenetic AS3MT Groups. Arsenic 35-42 arsenite methyltransferase Homo sapiens 10-15 33156617-0 2020 Predicted AS3MT Proteins Methylate Arsenic and Support Two Major Phylogenetic AS3MT Groups. Arsenic 35-42 arsenite methyltransferase Homo sapiens 78-83 33156617-4 2020 In this study, we evaluated whether 55 (out of which 47 were predicted based on protein sequence similarity) sequences encoding putative AS3MT orthologues in 47 species from different kingdoms can indeed methylate arsenic. Arsenic 214-221 arsenite methyltransferase Homo sapiens 137-142 33156617-6 2020 For example, the predicted AS3MT of the human gut bacterium Faecalibacterium prausnitzii methylated arsenic efficiently. Arsenic 100-107 arsenite methyltransferase Homo sapiens 27-32 33156617-10 2020 Further, it shows that humans carry two bacterial systems for arsenic methylation: one bacterium-derived AS3MT from Group 1 incorporated in the human genome and one from Group 2 in F. prausnitzii present in the gut microbiome. Arsenic 62-69 arsenite methyltransferase Homo sapiens 105-110 33340130-7 2021 The high inorganic arsenic urinary levels registered in the studied subjects suggest a reduction in the efficiency of As3MT, MRP1, and P-gp firstly because of gene polymorphisms and secondarily because of high internal inorganic arsenic levels. Arsenic 19-26 arsenite methyltransferase Homo sapiens 118-123 33141059-2 2020 The arsenic biotransformation enzyme AS3MT is known to participate in the generation of ROS after arsenic exposure, whereas MTH1 sanitizes oxidized dNTP pools to prevent the incorporation of damaged bases into DNA. Arsenic 4-11 arsenite methyltransferase Homo sapiens 37-42 33141059-2 2020 The arsenic biotransformation enzyme AS3MT is known to participate in the generation of ROS after arsenic exposure, whereas MTH1 sanitizes oxidized dNTP pools to prevent the incorporation of damaged bases into DNA. Arsenic 98-105 arsenite methyltransferase Homo sapiens 37-42 32971865-9 2020 An altered ability to methylate arsenic is dependent on specific single nucleotide polymorphisms (SNPs) in AS3MT. Arsenic 32-39 arsenite methyltransferase Homo sapiens 107-112 32452228-7 2020 Polymorphisms of AS3MT and ADRB3 genes showed no statistically significant correlation with urinary arsenic, however, there was a tendency to higher arsenic concentration in allele A carriers in locus rs4994 of ADRB3 gene and in allele T carriers in rs 11191439 of AS3MT gene. Arsenic 149-156 arsenite methyltransferase Homo sapiens 17-22 32971865-14 2020 NRF2 may be partly responsible for the biotransformation of iAs and the generation of methylated arsenic species via AS3MT. Arsenic 97-104 arsenite methyltransferase Homo sapiens 117-122 30153448-1 2018 BACKGROUND: Arsenic methylation efficiency, a susceptibility factor for arsenic toxicity, is in adults partly explained by variation in arsenite methyltransferase (AS3MT) gene. Arsenic 12-19 arsenite methyltransferase Homo sapiens 136-162 32650499-13 2020 Interactions between polymorphic variants As3MT*GSTM1 and GSTO2*GSTP1 could be potential modifiers of urinary excretion of arsenic and covariates as age, LADD, and alcohol consumption contribute to largely vary the arsenic individual metabolic capacity in exposed people. Arsenic 215-222 arsenite methyltransferase Homo sapiens 42-47 32112223-0 2020 Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3. Arsenic 17-24 arsenite methyltransferase Homo sapiens 66-71 30703610-6 2019 A panel of 63 candidate SNPs was selected for genotyping based on their reported associations with arsenic metabolism (including in As3MT, N6AMT1, and GSTO2 genes). Arsenic 99-106 arsenite methyltransferase Homo sapiens 132-137 30703610-11 2019 Further, As3MT, GSTO2, and N6AMT1 polymorphisms showed different effect sizes on DMA% conditional on arsenic exposure levels. Arsenic 101-108 arsenite methyltransferase Homo sapiens 9-14 30893314-4 2019 Arsenic metabolism efficiency varies among individuals, in part due to genetic variation near AS3MT (arsenite methyltransferase; 10q24.32). Arsenic 0-7 arsenite methyltransferase Homo sapiens 94-99 32433756-3 2020 Arsenic metabolism involves the AS3MT (arsenic methyltransferase) gene, and arsenic metabolism efficiency (AME, measured as relative concentrations of arsenic metabolites in urine) varies among individuals. Arsenic 0-7 arsenite methyltransferase Homo sapiens 32-37 32650499-0 2020 As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking Groundwater. Arsenic 40-47 arsenite methyltransferase Homo sapiens 0-5 32650499-9 2020 Univariate analyses among arsenic metabolites and genetic polymorphisms showed MMA concentrations higher in heterozygous and/or homozygous genotypes of As3MT compared to the wild-type genotype. Arsenic 26-33 arsenite methyltransferase Homo sapiens 152-157 32650499-13 2020 Interactions between polymorphic variants As3MT*GSTM1 and GSTO2*GSTP1 could be potential modifiers of urinary excretion of arsenic and covariates as age, LADD, and alcohol consumption contribute to largely vary the arsenic individual metabolic capacity in exposed people. Arsenic 123-130 arsenite methyltransferase Homo sapiens 42-47 32112223-1 2020 Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) have been shown to be related to interindividual variations in arsenic metabolism and to influence adverse health effects in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide (As2O3). Arsenic 17-24 arsenite methyltransferase Homo sapiens 66-71 32539644-0 2020 Association of arsenic-related AS3MT gene and antioxidant SOD2 gene expression in industrial workers occupationally exposed to arsenic. Arsenic 15-22 arsenite methyltransferase Homo sapiens 31-36 32539644-0 2020 Association of arsenic-related AS3MT gene and antioxidant SOD2 gene expression in industrial workers occupationally exposed to arsenic. Arsenic 127-134 arsenite methyltransferase Homo sapiens 31-36 32539644-10 2020 This study suggests that decreased AS3MT and SOD2 expression levels may lead to bioaccumulation of As in the body accompanied by increased oxidative stress ultimately inducing DNA damage. Arsenic 99-101 arsenite methyltransferase Homo sapiens 35-40 31330140-0 2019 Influence of AS3MT polymorphisms on arsenic metabolism and liver injury in APL patients treated with arsenic trioxide. Arsenic 36-43 arsenite methyltransferase Homo sapiens 13-18 31330140-2 2019 We recently demonstrated that AS3MT 14215 (rs3740390) genotypes were associated with urinary arsenic metabolites and hematological and biochemical values. Arsenic 93-100 arsenite methyltransferase Homo sapiens 30-35 31355259-10 2019 Taken together, these results prove that PC can promote arsenic methylation metabolism and efflux in L-02 cells, which may be related to the upregulation of GSH, MRP1, and AS3MT levels by PC. Arsenic 56-63 arsenite methyltransferase Homo sapiens 172-177 30543710-9 2018 AS3MT and MiR-548c-3p may regulate arsenic methylation jointly, which when involved in a group of relative mRNAs may play roles in arsenic metabolism and epigenetic changes caused by this metabolism. Arsenic 35-42 arsenite methyltransferase Homo sapiens 0-5 30543710-9 2018 AS3MT and MiR-548c-3p may regulate arsenic methylation jointly, which when involved in a group of relative mRNAs may play roles in arsenic metabolism and epigenetic changes caused by this metabolism. Arsenic 131-138 arsenite methyltransferase Homo sapiens 0-5 30153448-1 2018 BACKGROUND: Arsenic methylation efficiency, a susceptibility factor for arsenic toxicity, is in adults partly explained by variation in arsenite methyltransferase (AS3MT) gene. Arsenic 12-19 arsenite methyltransferase Homo sapiens 164-169 30153448-2 2018 Little is known about the role of AS3MT for children"s arsenic methylation. Arsenic 55-62 arsenite methyltransferase Homo sapiens 34-39 30153448-3 2018 OBJECTIVES: Evaluating associations between AS3MT polymorphisms and children"s arsenic methylation efficiency. Arsenic 79-86 arsenite methyltransferase Homo sapiens 44-49 30153448-12 2018 CONCLUSIONS: One out of four AS3MT polymorphisms, previously associated with arsenic methylation in adults, was associated with arsenic methylation in children. Arsenic 77-84 arsenite methyltransferase Homo sapiens 29-34 30153448-12 2018 CONCLUSIONS: One out of four AS3MT polymorphisms, previously associated with arsenic methylation in adults, was associated with arsenic methylation in children. Arsenic 128-135 arsenite methyltransferase Homo sapiens 29-34 30153448-13 2018 Thus, AS3MT variation seems to influence arsenic methylation efficiency in children to a lesser extent than in adults. Arsenic 41-48 arsenite methyltransferase Homo sapiens 6-11 29217265-5 2018 The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates. Arsenic 94-101 arsenite methyltransferase Homo sapiens 31-59 29859237-4 2018 The aims of this study were to evaluate 1) the association between arsenic methylation capacity and UTUC and/or BC, separately, and 2) the association between polymorphisms of the arsenic metabolism-related genes AS3MT, GSTOs, and PNP against BC and/or UTUC, separately. Arsenic 180-187 arsenite methyltransferase Homo sapiens 213-218 29894638-2 2018 Arsenic methylation by the enzyme As(III) S-adenosylmethionine (SAM) methyltransferase (ArsM in microbes or AS3MT in animals) detoxifies As(III) in microbes but transforms it into more toxic and potentially more carcinogenic methylated species in humans. Arsenic 0-7 arsenite methyltransferase Homo sapiens 108-113 29774349-1 2018 Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). Arsenic 87-94 arsenite methyltransferase Homo sapiens 0-46 29774349-1 2018 Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). Arsenic 87-94 arsenite methyltransferase Homo sapiens 48-53 29774349-2 2018 However, it is unclear whether the biotransformation of arsenic by AS3MT contributes to the promotion of acute promyelocytic leukemia (APL) therapy. Arsenic 56-63 arsenite methyltransferase Homo sapiens 67-72 29217265-5 2018 The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates. Arsenic 94-101 arsenite methyltransferase Homo sapiens 61-66 28728140-10 2017 CONCLUSION: Taken together, our findings indicate that As3MT acts to promote cardiovascular toxicity of arsenic and suggest that human AS3MT SNPs that correlate with enzyme function could predict those most at risk to develop atherosclerosis among the millions that are exposed to arsenic. Arsenic 104-111 arsenite methyltransferase Homo sapiens 55-60 29924282-0 2018 [Polymorphisms of the Arsenite Methyltransferase (As3MT) gene and urinary efficiency of arsenic metabolism in a population in northern Mexico]. Arsenic 88-95 arsenite methyltransferase Homo sapiens 22-48 29373862-16 2017 The association of arsenic metabolism with HOMA2-IR differed by B-vitamin intake and AS3MT genetics variants. Arsenic 19-26 arsenite methyltransferase Homo sapiens 85-90 28537708-0 2017 Nonsynonymous Polymorphisms in the Human AS3MT Arsenic Methylation Gene: Implications for Arsenic Toxicity. Arsenic 47-54 arsenite methyltransferase Homo sapiens 41-46 28537708-0 2017 Nonsynonymous Polymorphisms in the Human AS3MT Arsenic Methylation Gene: Implications for Arsenic Toxicity. Arsenic 90-97 arsenite methyltransferase Homo sapiens 41-46 28537708-1 2017 Arsenic methylation, the primary biotransformation in the human body, is catalyzed by the enzyme As(III) S-adenosylmethionine (SAM) methyltransferases (hAS3MT). Arsenic 0-7 arsenite methyltransferase Homo sapiens 152-158 28537708-3 2017 However, with long-term low-level exposure, hAS3MT produces intracellular methylarsenite (MAs(III)) and dimethylarsenite (DMAs(III)), which are considerably more toxic than inorganic As(III) and may contribute to arsenic-related diseases. Arsenic 213-220 arsenite methyltransferase Homo sapiens 44-50 28640505-2 2017 Arsenic (+3) methyltransferase (AS3MT) is the primary enzyme involved in arsenic metabolism, and we previously demonstrated in vitro that N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) also methylates the toxic inorganic arsenic (iAs) metabolite, monomethylarsonous acid (MMA), to the less toxic dimethylarsonic acid (DMA). Arsenic 228-235 arsenite methyltransferase Homo sapiens 32-37 28640505-0 2017 Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a chilean population. Arsenic 21-28 arsenite methyltransferase Homo sapiens 69-74 28640505-2 2017 Arsenic (+3) methyltransferase (AS3MT) is the primary enzyme involved in arsenic metabolism, and we previously demonstrated in vitro that N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) also methylates the toxic inorganic arsenic (iAs) metabolite, monomethylarsonous acid (MMA), to the less toxic dimethylarsonic acid (DMA). Arsenic 73-80 arsenite methyltransferase Homo sapiens 32-37 28640505-3 2017 Here, we evaluated whether AS3MT and N6AMT1 gene polymorphisms alter arsenic methylation and impact iAs-related cancer risks. Arsenic 69-76 arsenite methyltransferase Homo sapiens 27-32 28640505-6 2017 We found several AS3MT polymorphisms associated with both urinary arsenic metabolite profiles and cancer risk. Arsenic 66-73 arsenite methyltransferase Homo sapiens 17-22 28640505-10 2017 These results are the first to demonstrate a direct association between AS3MT polymorphisms and arsenic-related internal cancer risk. Arsenic 96-103 arsenite methyltransferase Homo sapiens 72-77 28426741-0 2017 AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes. Arsenic 28-35 arsenite methyltransferase Homo sapiens 0-5 28206677-3 2017 Therefore, to solve this conundrum we compared the frequencies of four protective genetic variants of the AS3MT gene associated with efficient arsenic metabolization, between the living populations of Camarones and two other populations historically exposed to lower levels of arsenic. Arsenic 143-150 arsenite methyltransferase Homo sapiens 106-111 28206677-3 2017 Therefore, to solve this conundrum we compared the frequencies of four protective genetic variants of the AS3MT gene associated with efficient arsenic metabolization, between the living populations of Camarones and two other populations historically exposed to lower levels of arsenic. Arsenic 277-284 arsenite methyltransferase Homo sapiens 106-111 28426741-4 2017 In humans, arsenite methyltransferase (AS3MT) appears to be the main metabolic enzyme that methylates arsenic. Arsenic 102-109 arsenite methyltransferase Homo sapiens 39-44 28426741-7 2017 These findings are supported by the observation that genetic variation in AS3MT correlates with the capacity to methylate arsenic. Arsenic 122-129 arsenite methyltransferase Homo sapiens 74-79 27637898-0 2017 Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China. Arsenic 64-71 arsenite methyltransferase Homo sapiens 36-41 28235556-2 2017 The present study was designed to explore whether polymorphisms and haplotypes of arsenic methyltransferase (AS3MT), glutathione-S-transferase omegas (GSTOs), and purine nucleoside phosphorylase (PNP) affect arsenic methylation capacity and developmental delay. Arsenic 82-89 arsenite methyltransferase Homo sapiens 109-114 28235556-13 2017 Our data provide evidence that AS3MT genes are related to developmental delay and may partially influence arsenic methylation capacity. Arsenic 106-113 arsenite methyltransferase Homo sapiens 31-36 28108741-3 2017 In fact, the enzymatic conversion of inorganic arsenic by Arsenic (+3 oxidation state) methyltransferase (AS3MT) to mono- and dimethylated arsenic species has long been considered as a major route for detoxification. Arsenic 58-65 arsenite methyltransferase Homo sapiens 106-111 28108741-3 2017 In fact, the enzymatic conversion of inorganic arsenic by Arsenic (+3 oxidation state) methyltransferase (AS3MT) to mono- and dimethylated arsenic species has long been considered as a major route for detoxification. Arsenic 47-54 arsenite methyltransferase Homo sapiens 106-111 27352405-12 2017 Among the candidate arsenic variant associations, functional SNPs in AS3MT and 10q24 were most significant (p < 9.33 x 10-5). Arsenic 20-27 arsenite methyltransferase Homo sapiens 69-74 27352405-13 2017 CONCLUSIONS: This hypothesis-driven association study supports the role of common variants in arsenic metabolism, particularly AS3MT and 10q24. Arsenic 94-101 arsenite methyltransferase Homo sapiens 127-132 28286610-8 2017 Due to genetic polymorphisms can contribute to the variability in AS3MT activity; they may contribute to interindividual as well as intra-ethnic differences in response to the detoxification of arsenic. Arsenic 194-201 arsenite methyltransferase Homo sapiens 66-71 27637898-2 2017 In humans, inorganic arsenic (iAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) mainly mediated by arsenic (+3 oxidation state) methyltransferase (As3MT). Arsenic 21-28 arsenite methyltransferase Homo sapiens 180-185 27637898-6 2017 Overall, we showed that N6AMT1 genetic polymorphisms were associated with arsenic biomethylation in the Chinese population, and its interaction with As3MT was observed in specific haplotype combinations. Arsenic 74-81 arsenite methyltransferase Homo sapiens 149-154 27692299-3 2016 This study aims to evaluate the association of the C10orf32 G to A polymorphism (rs9527), concerned with As3MT read-through transcription, with the development of arsenic induced skin lesions in the arsenic exposed individuals of West Bengal, India. Arsenic 163-170 arsenite methyltransferase Homo sapiens 105-110 27721063-1 2016 We previously reported that two splicing variants of human AS3MT mRNA, exon-3 skipping form (Delta3) and exons-4 and -5 skipping form (Delta4,5), were detected in HepG2 cells and that both variants lacked arsenic methylation activity (Sumi et al., 2011). Arsenic 205-212 arsenite methyltransferase Homo sapiens 59-64 27370415-0 2016 Association Between Variants in Arsenic (+3 Oxidation State) Methyltranserase (AS3MT) and Urinary Metabolites of Inorganic Arsenic: Role of Exposure Level. Arsenic 32-39 arsenite methyltransferase Homo sapiens 79-84 27370415-0 2016 Association Between Variants in Arsenic (+3 Oxidation State) Methyltranserase (AS3MT) and Urinary Metabolites of Inorganic Arsenic: Role of Exposure Level. Arsenic 123-130 arsenite methyltransferase Homo sapiens 79-84 27370415-1 2016 Variants in AS3MT, the gene encoding arsenic (+3 oxidation state) methyltranserase, have been shown to influence patterns of inorganic arsenic (iAs) metabolism. Arsenic 37-44 arsenite methyltransferase Homo sapiens 12-17 27370415-1 2016 Variants in AS3MT, the gene encoding arsenic (+3 oxidation state) methyltranserase, have been shown to influence patterns of inorganic arsenic (iAs) metabolism. Arsenic 135-142 arsenite methyltransferase Homo sapiens 12-17 26928318-1 2016 Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the metabolism of inorganic arsenic (iAs). Arsenic 104-111 arsenite methyltransferase Homo sapiens 48-53 26928318-0 2016 Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis. Arsenic 38-45 arsenite methyltransferase Homo sapiens 85-90 26928318-0 2016 Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis. Arsenic 120-127 arsenite methyltransferase Homo sapiens 85-90 26928318-1 2016 Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the metabolism of inorganic arsenic (iAs). Arsenic 104-111 arsenite methyltransferase Homo sapiens 0-46 26928318-3 2016 The relationships between seven single nucleotide polymorphisms (SNPs) in AS3MT and urinary concentrations of iAs and its methylated metabolites were assessed in mother-infant pairs of the Biomarkers of Exposure to ARsenic (BEAR) cohort. Arsenic 215-222 arsenite methyltransferase Homo sapiens 74-79 26209557-5 2015 We also examined the contribution of polymorphisms in the arsenic metabolism gene AS3MT via conditional linkage analysis. Arsenic 58-65 arsenite methyltransferase Homo sapiens 82-87 26577531-8 2015 These inhibitors may be useful tools for future research in arsenic metabolism and are the starting-point for the development of drugs against hAS3MT. Arsenic 60-67 arsenite methyltransferase Homo sapiens 143-149 25156000-0 2015 Genetic variation in arsenic (+3 oxidation state) methyltransferase (AS3MT), arsenic metabolism and risk of basal cell carcinoma in a European population. Arsenic 21-28 arsenite methyltransferase Homo sapiens 69-74 25997655-0 2015 Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation. Arsenic 43-50 arsenite methyltransferase Homo sapiens 34-39 25997655-1 2015 In humans, arsenic is primarily metabolized by arsenic (+3 oxidation state) methyltransferase (As3MT) to yield both trivalent and pentavalent methylated metabolites. Arsenic 11-18 arsenite methyltransferase Homo sapiens 47-93 25997655-1 2015 In humans, arsenic is primarily metabolized by arsenic (+3 oxidation state) methyltransferase (As3MT) to yield both trivalent and pentavalent methylated metabolites. Arsenic 11-18 arsenite methyltransferase Homo sapiens 95-100 26366023-1 2015 Efflux is by far the most common means of arsenic detoxification is by methylation catalyzed by a family of As(III) S-adenosylmethionine (SAM) methyltransferases (MTs) enzymes designated ArsM in microbes or AS3MT in higher eukaryotes. Arsenic 42-49 arsenite methyltransferase Homo sapiens 207-212 25768001-7 2015 Regional heritability analysis confirmed 10q24.32 (AS3MT) as a major arsenic metabolism locus (PVE = 7%, p = 4.4 x 10(-10)), but revealed no additional regions. Arsenic 69-76 arsenite methyltransferase Homo sapiens 51-56 25768001-10 2015 CONCLUSIONS: Our results suggest that there are common variants outside of the AS3MT region that influence arsenic metabolism in Bangladeshi individuals, but the effects of these variants are very weak compared with variants near AS3MT. Arsenic 107-114 arsenite methyltransferase Homo sapiens 79-84 25491248-0 2015 Biological monitoring and the influence of genetic polymorphism of As3MT and GSTs on distribution of urinary arsenic species in occupational exposure workers. Arsenic 109-116 arsenite methyltransferase Homo sapiens 67-72 25866076-2 2015 As(III) S-adenosylmethionine methyltransferases (AS3MT in mammals and ArsM in microbes) methylate As(III) three times in consecutive steps and play a central role in arsenic metabolism from bacteria to humans. Arsenic 166-173 arsenite methyltransferase Homo sapiens 49-54 25739736-3 2015 We genotyped women from this population for 4,301,332 single nucleotide polymorphisms (SNPs) and found a strong association between the AS3MT (arsenic [+3 oxidation state] methyltransferase) gene and mono- and dimethylated arsenic in urine, suggesting that AS3MT functions as the major gene for arsenic metabolism in humans. Arsenic 143-150 arsenite methyltransferase Homo sapiens 136-141 25739736-3 2015 We genotyped women from this population for 4,301,332 single nucleotide polymorphisms (SNPs) and found a strong association between the AS3MT (arsenic [+3 oxidation state] methyltransferase) gene and mono- and dimethylated arsenic in urine, suggesting that AS3MT functions as the major gene for arsenic metabolism in humans. Arsenic 223-230 arsenite methyltransferase Homo sapiens 136-189 25739736-3 2015 We genotyped women from this population for 4,301,332 single nucleotide polymorphisms (SNPs) and found a strong association between the AS3MT (arsenic [+3 oxidation state] methyltransferase) gene and mono- and dimethylated arsenic in urine, suggesting that AS3MT functions as the major gene for arsenic metabolism in humans. Arsenic 223-230 arsenite methyltransferase Homo sapiens 136-141 25739736-7 2015 Our data show that adaptation to tolerate the environmental stressor arsenic has likely driven an increase in the frequencies of protective variants of AS3MT, providing the first evidence of human adaptation to a toxic chemical. Arsenic 69-76 arsenite methyltransferase Homo sapiens 152-157 25156000-2 2015 Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated with increased urinary fractions of the most toxic arsenic metabolite, methylarsonic acid (MMA). Arsenic 0-7 arsenite methyltransferase Homo sapiens 143-148 25156000-2 2015 Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated with increased urinary fractions of the most toxic arsenic metabolite, methylarsonic acid (MMA). Arsenic 50-57 arsenite methyltransferase Homo sapiens 143-148 25156000-2 2015 Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated with increased urinary fractions of the most toxic arsenic metabolite, methylarsonic acid (MMA). Arsenic 95-102 arsenite methyltransferase Homo sapiens 143-148 25156000-3 2015 The aim of this study is to elucidate the association of AS3MT haplotypes with arsenic metabolism and the risk of BCC. Arsenic 79-86 arsenite methyltransferase Homo sapiens 57-62 25156000-9 2015 The results suggest that carriage of AS3MT haplotypes associated with less-efficient arsenic methylation, or lack of AS3MT haplotypes associated with a more-efficient arsenic methylation, results in higher risk of arsenic-related BCC. Arsenic 85-92 arsenite methyltransferase Homo sapiens 37-42 25156000-9 2015 The results suggest that carriage of AS3MT haplotypes associated with less-efficient arsenic methylation, or lack of AS3MT haplotypes associated with a more-efficient arsenic methylation, results in higher risk of arsenic-related BCC. Arsenic 167-174 arsenite methyltransferase Homo sapiens 117-122 25156000-10 2015 The fact that AS3MT haplotype status modified arsenic metabolism, and in turn the arsenic-related BCC risk, supports a causal relationship between low-level arsenic exposure and BCC. Arsenic 46-53 arsenite methyltransferase Homo sapiens 14-19 25156000-10 2015 The fact that AS3MT haplotype status modified arsenic metabolism, and in turn the arsenic-related BCC risk, supports a causal relationship between low-level arsenic exposure and BCC. Arsenic 82-89 arsenite methyltransferase Homo sapiens 14-19 25156000-10 2015 The fact that AS3MT haplotype status modified arsenic metabolism, and in turn the arsenic-related BCC risk, supports a causal relationship between low-level arsenic exposure and BCC. Arsenic 82-89 arsenite methyltransferase Homo sapiens 14-19 25349987-1 2014 Arsenic (III) methyltransferase (AS3MT) is a cysteine (Cys)-rich enzyme that catalyzes the biomethylation of arsenic. Arsenic 109-116 arsenite methyltransferase Homo sapiens 33-38 26411936-2 2015 Genetic polymorphisms such as single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT), which can methylate arsenic compounds using S-adenosyl-l-methionine (AdoMet), have been reported to modify arsenic methylation. Arsenic 72-79 arsenite methyltransferase Homo sapiens 120-125 26411936-2 2015 Genetic polymorphisms such as single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT), which can methylate arsenic compounds using S-adenosyl-l-methionine (AdoMet), have been reported to modify arsenic methylation. Arsenic 148-155 arsenite methyltransferase Homo sapiens 72-118 26411936-2 2015 Genetic polymorphisms such as single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT), which can methylate arsenic compounds using S-adenosyl-l-methionine (AdoMet), have been reported to modify arsenic methylation. Arsenic 148-155 arsenite methyltransferase Homo sapiens 120-125 26411936-3 2015 In this review, we summarize studies conducted by us in Vietnam and by others on the association of AS3MT genetic polymorphisms with arsenic metabolism as well as human health effects. Arsenic 133-140 arsenite methyltransferase Homo sapiens 100-105 26411936-4 2015 Most of the SNPs in AS3MT showed inconsistent results in terms of genotype-dependent differences in arsenic metabolism among the studies. Arsenic 100-107 arsenite methyltransferase Homo sapiens 20-25 26411936-5 2015 However, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the study population: AS3MT 12390 (rs3740393) affected the second step of methylation of arsenic, whereas 14458 (rs11191439) affected the first methylation step. Arsenic 85-92 arsenite methyltransferase Homo sapiens 9-14 26411936-5 2015 However, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the study population: AS3MT 12390 (rs3740393) affected the second step of methylation of arsenic, whereas 14458 (rs11191439) affected the first methylation step. Arsenic 85-92 arsenite methyltransferase Homo sapiens 141-146 26411936-5 2015 However, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the study population: AS3MT 12390 (rs3740393) affected the second step of methylation of arsenic, whereas 14458 (rs11191439) affected the first methylation step. Arsenic 208-215 arsenite methyltransferase Homo sapiens 141-146 25349987-8 2014 In recovery experiments, we confirmed that trivalent arsenicals were substrates for hAS3MT, methylation of arsenic occurred on the enzyme, and an intramolecular disulfide bond might be formed after iAs3+ was methylated to dimethylarsinous acid (DMA3+). Arsenic 53-60 arsenite methyltransferase Homo sapiens 84-90 24726863-1 2014 Inorganic arsenic(As) is metabolized through a series of methylation reactions catalyzed by arsenic(III)-methyltransferase (AS3MT), resulting in the generation of monomethylarsonic (MMAs) and dimethylarsinic acids (DMAs). Arsenic 18-20 arsenite methyltransferase Homo sapiens 124-129 28962272-4 2014 The methylation of As is catalyzed by arsenic (+3 oxidation state) methyltransferase (AS3MT). Arsenic 19-21 arsenite methyltransferase Homo sapiens 38-84 28962272-4 2014 The methylation of As is catalyzed by arsenic (+3 oxidation state) methyltransferase (AS3MT). Arsenic 19-21 arsenite methyltransferase Homo sapiens 86-91 28962272-11 2014 We conclude that AS3MT catalyzes the methylation of As and not other biomethylatable metalloids, such as Se and Te. Arsenic 52-54 arsenite methyltransferase Homo sapiens 17-22 24792412-0 2014 AS3MT, GSTO, and PNP polymorphisms: impact on arsenic methylation and implications for disease susceptibility. Arsenic 46-53 arsenite methyltransferase Homo sapiens 0-5 24593923-6 2014 Additionally, the at-risk genotypes of the AS3MT SNPs were positively related to the proportion of monomethylarsonic acid (MMA) in urine, which is indicative of arsenic methylation capacity. Arsenic 161-168 arsenite methyltransferase Homo sapiens 43-48 24598884-3 2014 Both reactions are catalyzed by arsenic (+3 oxidation state) methyltransferase (AS3MT) using S-adenosylmethionine (SAM) as the methyl donor, yielding the methylated product and S-adenosylhomocysteine (SAH), a potent product-inhibitor of AS3MT. Arsenic 32-39 arsenite methyltransferase Homo sapiens 80-85 24598884-3 2014 Both reactions are catalyzed by arsenic (+3 oxidation state) methyltransferase (AS3MT) using S-adenosylmethionine (SAM) as the methyl donor, yielding the methylated product and S-adenosylhomocysteine (SAH), a potent product-inhibitor of AS3MT. Arsenic 32-39 arsenite methyltransferase Homo sapiens 237-242 24621105-5 2014 Among those with the AA genotype of the AS3MT gene, arsenic levels were negatively associated with language (p < 0.001), attention (p = 0.01), and executive functioning (p = 0.04). Arsenic 52-59 arsenite methyltransferase Homo sapiens 40-45 24621105-8 2014 CONCLUSIONS: Low-level arsenic exposure is associated with cognitive functioning; however, this association is modified by an AS3MT gene. Arsenic 23-30 arsenite methyltransferase Homo sapiens 126-131 23341986-0 2013 Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT. Arsenic 10-17 arsenite methyltransferase Homo sapiens 34-39 24154821-4 2014 In this study, we evaluated AS3MT promoter methylation according to exposure, assessed by urinary arsenic excretion in a stratified random sample of 48 participants from the Strong Heart Study who had urine arsenic measured at baseline and DNA available from 1989 to 1991 and 1998-1999. Arsenic 98-105 arsenite methyltransferase Homo sapiens 28-33 24154821-8 2014 A hypomethylated region in the AS3MT promoter was associated with higher arsenic exposure. Arsenic 73-80 arsenite methyltransferase Homo sapiens 31-36 24154821-9 2014 In vitro, arsenic induced AS3MT promoter hypomethylation, and it increased AS3MT expression in human peripheral blood mononuclear cells. Arsenic 10-17 arsenite methyltransferase Homo sapiens 26-31 24154821-9 2014 In vitro, arsenic induced AS3MT promoter hypomethylation, and it increased AS3MT expression in human peripheral blood mononuclear cells. Arsenic 10-17 arsenite methyltransferase Homo sapiens 75-80 24361376-0 2014 Micronucleus frequency in copper-mine workers exposed to arsenic is modulated by the AS3MT Met287Thr polymorphism. Arsenic 57-64 arsenite methyltransferase Homo sapiens 85-90 24361376-1 2014 Arsenic(III)methyltransferase (AS3MT) has been demonstrated to be the key enzyme in the metabolism of arsenic as it catalyses the methylation of arsenite and monomethylarsonic acid (MMA) to form methylated arsenic species, which have higher toxic and genotoxic potential than the parent compounds. Arsenic 102-109 arsenite methyltransferase Homo sapiens 31-36 24361376-1 2014 Arsenic(III)methyltransferase (AS3MT) has been demonstrated to be the key enzyme in the metabolism of arsenic as it catalyses the methylation of arsenite and monomethylarsonic acid (MMA) to form methylated arsenic species, which have higher toxic and genotoxic potential than the parent compounds. Arsenic 206-213 arsenite methyltransferase Homo sapiens 31-36 24361376-2 2014 The aim of this study is to evaluate if genetic variation in the AS3MT gene influences arsenic-induced cytogenetic damage, measured by the micronucleus (MN) assay. Arsenic 87-94 arsenite methyltransferase Homo sapiens 65-70 24361376-7 2014 To our knowledge, these results are the first to show that genetic variation in AS3MT, especially the Met287Thr polymorphism, may play a role in modulating the levels of arsenic-induced cytogenetic damage among individuals chronically exposed to arsenic. Arsenic 170-177 arsenite methyltransferase Homo sapiens 80-85 24361376-7 2014 To our knowledge, these results are the first to show that genetic variation in AS3MT, especially the Met287Thr polymorphism, may play a role in modulating the levels of arsenic-induced cytogenetic damage among individuals chronically exposed to arsenic. Arsenic 246-253 arsenite methyltransferase Homo sapiens 80-85 24239724-5 2014 The percent MMA of individuals with the A2B/A2B genotype of arsenic (+3 oxidation state) methyltransferase (AS3MT) was significantly lower than those with AB/A2B. Arsenic 60-67 arsenite methyltransferase Homo sapiens 108-113 24391919-1 2013 Arsenic (III) methyltransferase (AS3MT) catalyzes the process of arsenic methylation. Arsenic 65-72 arsenite methyltransferase Homo sapiens 33-38 24391919-3 2013 However, only two As-binding sites (Cys156 and Cys206) have been confirmed on human AS3MT (hAS3MT). Arsenic 18-20 arsenite methyltransferase Homo sapiens 84-89 24391919-3 2013 However, only two As-binding sites (Cys156 and Cys206) have been confirmed on human AS3MT (hAS3MT). Arsenic 18-20 arsenite methyltransferase Homo sapiens 91-97 24391919-17 2013 The distances between S(C61) and arsenic in WT-hAS3MT-As and WT-hAS3MT-SAM-As models are 7.5 A and 4.1 A, respectively. Arsenic 33-40 arsenite methyltransferase Homo sapiens 47-53 24391919-17 2013 The distances between S(C61) and arsenic in WT-hAS3MT-As and WT-hAS3MT-SAM-As models are 7.5 A and 4.1 A, respectively. Arsenic 33-40 arsenite methyltransferase Homo sapiens 64-70 24391919-18 2013 This indicates that SAM-binding to hAS3MT shortens the distance between S(C61) and arsenic and promotes As-binding to hAS3MT. Arsenic 83-90 arsenite methyltransferase Homo sapiens 35-41 24391919-18 2013 This indicates that SAM-binding to hAS3MT shortens the distance between S(C61) and arsenic and promotes As-binding to hAS3MT. Arsenic 104-106 arsenite methyltransferase Homo sapiens 35-41 24391919-18 2013 This indicates that SAM-binding to hAS3MT shortens the distance between S(C61) and arsenic and promotes As-binding to hAS3MT. Arsenic 104-106 arsenite methyltransferase Homo sapiens 118-124 24391919-20 2013 Model of WT-hAS3MT-SAM-As and the experimental results indicate that Cys61 is the third As-binding site. Arsenic 23-25 arsenite methyltransferase Homo sapiens 12-18 23665909-1 2013 BACKGROUND: In humans, inorganic arsenic is metabolized to methylated metabolites mainly by arsenic (+3 oxidation state) methyltransferase (AS3MT). Arsenic 33-40 arsenite methyltransferase Homo sapiens 92-138 23665909-1 2013 BACKGROUND: In humans, inorganic arsenic is metabolized to methylated metabolites mainly by arsenic (+3 oxidation state) methyltransferase (AS3MT). Arsenic 33-40 arsenite methyltransferase Homo sapiens 140-145 23322787-1 2013 BACKGROUND: Arsenic (III) methyltransferase (AS3MT) has been related to urine arsenic metabolites in association studies. Arsenic 78-85 arsenite methyltransferase Homo sapiens 45-50 23093101-2 2013 We previously reported an association of diabetes and urinary concentration of dimethylarsinite (DMAs(III)), a toxic product of arsenic methylation by arsenic (+3 oxidation state) methyltransferase (AS3MT). Arsenic 128-135 arsenite methyltransferase Homo sapiens 199-204 23093101-2 2013 We previously reported an association of diabetes and urinary concentration of dimethylarsinite (DMAs(III)), a toxic product of arsenic methylation by arsenic (+3 oxidation state) methyltransferase (AS3MT). Arsenic 151-158 arsenite methyltransferase Homo sapiens 199-204 23070617-3 2013 Inhabitants of San Antonio de los Cobres (SAC) in the Argentinean highlands generally carry an AS3MT (the major arsenic-metabolizing gene) haplotype associated with reduced health risks due to rapid arsenic excretion and lower urinary fraction of the monomethylated metabolite. Arsenic 112-119 arsenite methyltransferase Homo sapiens 95-100 23341986-0 2013 Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT. Arsenic 10-17 arsenite methyltransferase Homo sapiens 125-130 23341986-5 2013 Here, we assessed the influence of genetic variation in AS3MT on DNA methylation and gene expression within 10q24, in people exposed to arsenic in drinking water. Arsenic 136-143 arsenite methyltransferase Homo sapiens 56-61 22917110-9 2012 Similarly, carriers of the slow and more toxic metabolizing AS3MT haplotype showed stronger positive associations between arsenic exposure and telomere length, as compared to noncarriers (interaction urinary arsenic and haplotype p = 0.025). Arsenic 122-129 arsenite methyltransferase Homo sapiens 60-65 22917110-9 2012 Similarly, carriers of the slow and more toxic metabolizing AS3MT haplotype showed stronger positive associations between arsenic exposure and telomere length, as compared to noncarriers (interaction urinary arsenic and haplotype p = 0.025). Arsenic 208-215 arsenite methyltransferase Homo sapiens 60-65 22339537-1 2012 We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Arsenic 111-118 arsenite methyltransferase Homo sapiens 142-147 22868225-0 2012 Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione. Arsenic 15-22 arsenite methyltransferase Homo sapiens 54-100 22868225-9 2012 AS3MT genotype exemplified by differences in regulation of wtAS3MT and AS3MT/M287T-catalyzed reactions by GSH may contribute to differences in the phenotype for arsenic methylation and, ultimately, to differences in the disease susceptibility in individuals chronically exposed to inorganic arsenic. Arsenic 161-168 arsenite methyltransferase Homo sapiens 0-5 22868225-9 2012 AS3MT genotype exemplified by differences in regulation of wtAS3MT and AS3MT/M287T-catalyzed reactions by GSH may contribute to differences in the phenotype for arsenic methylation and, ultimately, to differences in the disease susceptibility in individuals chronically exposed to inorganic arsenic. Arsenic 161-168 arsenite methyltransferase Homo sapiens 61-66 22747749-10 2012 CONCLUSIONS: Variation in As3MT and MTHFR is associated with bladder cancer among those exposed to relatively low concentrations of inorganic arsenic. Arsenic 142-149 arsenite methyltransferase Homo sapiens 26-31 22339537-5 2012 Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion. Arsenic 44-51 arsenite methyltransferase Homo sapiens 31-36 22339537-5 2012 Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion. Arsenic 95-102 arsenite methyltransferase Homo sapiens 31-36 21750349-6 2011 Metabolism of arsenic, catalyzed by arsenic (+3 oxidation state) methyltransferase, is a sequential process of reduction from pentavalency to trivalency followed by oxidative methylation back to pentavalency. Arsenic 14-21 arsenite methyltransferase Homo sapiens 36-82 23123458-3 2012 In 2002, arsenite (+3 oxidation state) methyltransferase (As3MT) was discovered to be an enzyme responsible for arsenic methylation. Arsenic 112-119 arsenite methyltransferase Homo sapiens 58-63 23123458-4 2012 This review focuses on current information on the function, genetic polymorphism, and alternative splicing of As3MT, all of which contribute to arsenic metabolism and toxicity. Arsenic 144-151 arsenite methyltransferase Homo sapiens 110-115 22005461-1 2011 Arsenic (+3 oxidation state) methyltransferase (As3MT) catalyzes the methylation of trivalent arsenic (As(III)) to monomethylarsonate (MMA(V)) and dimethylarsinic acid (DMA(V)), and plays an important role in the detoxification of arsenicals. Arsenic 94-101 arsenite methyltransferase Homo sapiens 0-46 22005461-1 2011 Arsenic (+3 oxidation state) methyltransferase (As3MT) catalyzes the methylation of trivalent arsenic (As(III)) to monomethylarsonate (MMA(V)) and dimethylarsinic acid (DMA(V)), and plays an important role in the detoxification of arsenicals. Arsenic 94-101 arsenite methyltransferase Homo sapiens 48-53 22005461-9 2011 These data suggest that the expression pattern of splicing variants of the As3MT gene may affect the capacity for arsenic methylation in cells. Arsenic 114-121 arsenite methyltransferase Homo sapiens 75-80 21605854-2 2011 The purpose of this study is to explore the interaction effect on risk of carotid atherosclerosis between arsenic exposure and risk genotypes of purine nucleoside phosphorylase (PNP), arsenic (+3) methyltransferase (As3MT), and glutathione S-transferase omega 1 (GSTO1) and omega 2 (GSTO2). Arsenic 106-113 arsenite methyltransferase Homo sapiens 216-221 21605854-10 2011 In conclusion, arsenic metabolic genes, PNP, As3MT, and GSTO, may exacerbate the formation of atherosclerosis in individuals with high levels of arsenic concentration in well water (>50mug/l). Arsenic 145-152 arsenite methyltransferase Homo sapiens 45-50 21247820-0 2011 Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Arsenic 17-24 arsenite methyltransferase Homo sapiens 66-71 21537954-1 2011 It has been suggested that arsenic (+3 oxidation state) methyltransferase (AS3MT) plays a critical role in methylation of arsenic, and that arsenic-glutathione conjugate is a substrate for AS3MT-catalyzed methylation of arsenic. Arsenic 27-34 arsenite methyltransferase Homo sapiens 75-80 21537954-1 2011 It has been suggested that arsenic (+3 oxidation state) methyltransferase (AS3MT) plays a critical role in methylation of arsenic, and that arsenic-glutathione conjugate is a substrate for AS3MT-catalyzed methylation of arsenic. Arsenic 27-34 arsenite methyltransferase Homo sapiens 189-194 21537954-1 2011 It has been suggested that arsenic (+3 oxidation state) methyltransferase (AS3MT) plays a critical role in methylation of arsenic, and that arsenic-glutathione conjugate is a substrate for AS3MT-catalyzed methylation of arsenic. Arsenic 122-129 arsenite methyltransferase Homo sapiens 27-73 21537954-1 2011 It has been suggested that arsenic (+3 oxidation state) methyltransferase (AS3MT) plays a critical role in methylation of arsenic, and that arsenic-glutathione conjugate is a substrate for AS3MT-catalyzed methylation of arsenic. Arsenic 122-129 arsenite methyltransferase Homo sapiens 75-80 21537954-1 2011 It has been suggested that arsenic (+3 oxidation state) methyltransferase (AS3MT) plays a critical role in methylation of arsenic, and that arsenic-glutathione conjugate is a substrate for AS3MT-catalyzed methylation of arsenic. Arsenic 122-129 arsenite methyltransferase Homo sapiens 27-73 21537954-1 2011 It has been suggested that arsenic (+3 oxidation state) methyltransferase (AS3MT) plays a critical role in methylation of arsenic, and that arsenic-glutathione conjugate is a substrate for AS3MT-catalyzed methylation of arsenic. Arsenic 122-129 arsenite methyltransferase Homo sapiens 75-80 21537954-11 2011 These findings indicated that AS3MT expression enhanced the cytotoxic effect of arsenite in tet(+) cells because these cells accumulated more arsenic metabolites than did the tet(-) cells, and accordingly, the tet(+) cells were more susceptible to arsenic than were the tet(-) cells. Arsenic 142-149 arsenite methyltransferase Homo sapiens 30-35 21537954-11 2011 These findings indicated that AS3MT expression enhanced the cytotoxic effect of arsenite in tet(+) cells because these cells accumulated more arsenic metabolites than did the tet(-) cells, and accordingly, the tet(+) cells were more susceptible to arsenic than were the tet(-) cells. Arsenic 248-255 arsenite methyltransferase Homo sapiens 30-35 20571777-0 2011 Genetic variants associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase show wide variation across multiple populations. Arsenic 33-40 arsenite methyltransferase Homo sapiens 65-111 21320519-6 2011 Multivariate regression models showed that higher BMI, arsenic (+3 oxidation state) methyltransferase (AS3MT) genetic variant 7388, and higher total urinary arsenic were significantly associated with low percentage of urinary arsenic excreted as monomethylarsonic acid (%uMMA) or high ratio between urinary dimethylarsinic acid and uMMA (uDMA/uMMA), while AS3MT genetic variant M287T was associated with high %uMMA and low uDMA/uMMA. Arsenic 55-62 arsenite methyltransferase Homo sapiens 103-108 21320519-6 2011 Multivariate regression models showed that higher BMI, arsenic (+3 oxidation state) methyltransferase (AS3MT) genetic variant 7388, and higher total urinary arsenic were significantly associated with low percentage of urinary arsenic excreted as monomethylarsonic acid (%uMMA) or high ratio between urinary dimethylarsinic acid and uMMA (uDMA/uMMA), while AS3MT genetic variant M287T was associated with high %uMMA and low uDMA/uMMA. Arsenic 157-164 arsenite methyltransferase Homo sapiens 356-361 21247820-0 2011 Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Arsenic 17-24 arsenite methyltransferase Homo sapiens 100-105 21247820-0 2011 Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Arsenic 117-124 arsenite methyltransferase Homo sapiens 66-71 19680750-11 2009 Through GLM, significant gene effects of arsenic (+3 oxidation state)-methyltransferase (AS3MT) on MMA%, dimethylarsinic acid percentage (DMA%) and DMA/MMA, purine nucleoside phosphorylase (PNP) on DMA% and glutathione S-transferase omega 2 (GSTO2) on inorganic arsenics (InAs%) were found. Arsenic 41-48 arsenite methyltransferase Homo sapiens 89-94 20949432-2 2010 Identification of arsenic (+3 oxidation state) methyltransferase (As3mt) as the enzyme that could catalyze all the steps in the pathway for arsenic methylation suggests that expression of this enzyme could be a useful target for manipulation. Arsenic 18-25 arsenite methyltransferase Homo sapiens 66-71 21731446-0 2011 Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms. Arsenic 35-42 arsenite methyltransferase Homo sapiens 70-75 21731446-2 2011 Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans. Arsenic 155-162 arsenite methyltransferase Homo sapiens 0-46 21731446-2 2011 Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans. Arsenic 155-162 arsenite methyltransferase Homo sapiens 48-53 21731446-3 2011 Since the genetic polymorphisms of AS3MT gene may be associated with the susceptibility to inorganic arsenic toxicity, relationships of several single nucleotide polymorphisms (SNPs) in AS3MT with inorganic arsenic metabolism have been investigated. Arsenic 101-108 arsenite methyltransferase Homo sapiens 35-40 21731446-5 2011 Results of genotype dependent differences in arsenic metabolism for most of SNPs in AS3MT were Inconsistent throughout the studies. Arsenic 45-52 arsenite methyltransferase Homo sapiens 84-89 21731446-6 2011 Nevertheless, two SNPs, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the populations examined for the analysis. Arsenic 100-107 arsenite methyltransferase Homo sapiens 24-29 20532380-0 2010 Genetic polymorphism of As3MT and delayed urinary DMA excretion after organic arsenic intake from oyster ingestion. Arsenic 78-85 arsenite methyltransferase Homo sapiens 24-29 20532380-3 2010 The goal of this study was to explore the effects of genetic polymorphisms of human PNP, As3MT and GSTO1 on organic arsenic metabolism among study subjects after oyster ingestion. Arsenic 116-123 arsenite methyltransferase Homo sapiens 89-94 20532380-10 2010 As3MT was suggested to be one of the major factors affecting the metabolism of dietary organic arsenic in terms of urinary DMA level. Arsenic 95-102 arsenite methyltransferase Homo sapiens 0-5 20014157-0 2010 Genetic association between intronic variants in AS3MT and arsenic methylation efficiency is focused on a large linkage disequilibrium cluster in chromosome 10. Arsenic 59-66 arsenite methyltransferase Homo sapiens 49-54 20014157-3 2010 Specifically, variants in arsenic (3+ oxidation state) methyltransferase (AS3MT), the key gene in the metabolism of arsenic, have been associated with increased arsenic methylation efficiency. Arsenic 26-33 arsenite methyltransferase Homo sapiens 74-79 20014157-3 2010 Specifically, variants in arsenic (3+ oxidation state) methyltransferase (AS3MT), the key gene in the metabolism of arsenic, have been associated with increased arsenic methylation efficiency. Arsenic 116-123 arsenite methyltransferase Homo sapiens 26-72 20014157-3 2010 Specifically, variants in arsenic (3+ oxidation state) methyltransferase (AS3MT), the key gene in the metabolism of arsenic, have been associated with increased arsenic methylation efficiency. Arsenic 116-123 arsenite methyltransferase Homo sapiens 74-79 20014157-5 2010 In an effort to characterize the extent of the region in LD, we genotyped 46 SNPs in a 347,000 base region of chromosome 10 that included AS3MT in arsenic-exposed subjects from Mexico. Arsenic 147-154 arsenite methyltransferase Homo sapiens 138-143 20014157-7 2010 Genetic association analysis with arsenic metabolism confirmed the previously observed association between AS3MT variants, including this large cluster of linked polymorphisms, and arsenic methylation efficiency. Arsenic 34-41 arsenite methyltransferase Homo sapiens 107-112 20014157-7 2010 Genetic association analysis with arsenic metabolism confirmed the previously observed association between AS3MT variants, including this large cluster of linked polymorphisms, and arsenic methylation efficiency. Arsenic 181-188 arsenite methyltransferase Homo sapiens 107-112 19914269-8 2010 Furthermore, other factors including sex, age, body mass index, arsenic level in drinking water, and genotypes of As (+3 oxidation state) methyltransferase (AS3MT) were also significantly co-associated with arsenic level and profile in the Vietnamese. Arsenic 207-214 arsenite methyltransferase Homo sapiens 157-162 19680750-11 2009 Through GLM, significant gene effects of arsenic (+3 oxidation state)-methyltransferase (AS3MT) on MMA%, dimethylarsinic acid percentage (DMA%) and DMA/MMA, purine nucleoside phosphorylase (PNP) on DMA% and glutathione S-transferase omega 2 (GSTO2) on inorganic arsenics (InAs%) were found. Arsenic 262-270 arsenite methyltransferase Homo sapiens 89-94 18682255-10 2009 CONCLUSIONS: Polymorphisms in AS3MT and in genes involved in one-carbon metabolism and reduction reactions affects arsenic metabolism. Arsenic 115-122 arsenite methyltransferase Homo sapiens 30-35 19691357-2 2009 Altered expression of AS3MT in cultured human cells controls arsenic methylation phenotypes, suggesting a critical role in arsenic metabolism. Arsenic 61-68 arsenite methyltransferase Homo sapiens 22-27 19691357-2 2009 Altered expression of AS3MT in cultured human cells controls arsenic methylation phenotypes, suggesting a critical role in arsenic metabolism. Arsenic 123-130 arsenite methyltransferase Homo sapiens 22-27 19152805-3 2009 Only recently have genes encoding enzymes responsible for arsenic metabolism, such as AS3MT and GSTO, been cloned and characterized. Arsenic 58-65 arsenite methyltransferase Homo sapiens 86-91 19538983-5 2009 In this study, we evaluated the association of the polymorphism in AS3MT gene with iAs metabolism and with the presence of arsenic (As) premalignant skin lesions. Arsenic 123-130 arsenite methyltransferase Homo sapiens 67-72 19538983-5 2009 In this study, we evaluated the association of the polymorphism in AS3MT gene with iAs metabolism and with the presence of arsenic (As) premalignant skin lesions. Arsenic 84-86 arsenite methyltransferase Homo sapiens 67-72 18682255-5 2009 RESULTS: Genetic factors affecting arsenic metabolite pattern included two polymorphisms in arsenic (+III) methyltransferase (AS3MT) (rs3740400, rs7085104), where carriers had lower %MMA and higher %DMA. Arsenic 35-42 arsenite methyltransferase Homo sapiens 126-131 18682255-6 2009 These single nucleotide polymorphisms (SNPs) were in strong linkage disequilibrium (LD) with three intronic AS3MT SNPs, previously reported to be associated with arsenic metabolism, indicating the existence of a strongly methylating, population-specific haplotype. Arsenic 162-169 arsenite methyltransferase Homo sapiens 108-113 19371612-1 2009 To elucidate the role of genetic factors in arsenic (As) metabolism, we studied associations of single nucleotide polymorphisms (SNPs) in As (+3 oxidation state) methyltransferase (AS3MT) with the As concentrations in hair and urine, and urinary As profile in residents in the Red River Delta, Vietnam. Arsenic 138-140 arsenite methyltransferase Homo sapiens 181-186 19411561-2 2009 The enzymatic methylation of iAs that is catalyzed by arsenic (+3 oxidation state)-methyltransferase (AS3MT) generates reactive methylated intermediates that contribute to the toxic and carcinogenic effects of iAs. Arsenic 54-61 arsenite methyltransferase Homo sapiens 102-107 18524450-3 2008 The expression of two enzymes responsible for arsenic biotransformation arsenic methyltranferase (AS3MT) and glutathione S-transferase omega 1 (GSTO1) was evaluated in human cord blood cells. Arsenic 46-53 arsenite methyltransferase Homo sapiens 98-103 18976679-0 2009 Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene. Arsenic 66-73 arsenite methyltransferase Homo sapiens 98-144 18976679-0 2009 Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene. Arsenic 66-73 arsenite methyltransferase Homo sapiens 146-151 18976679-1 2009 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite, and intronic single-nucleotide polymorphisms (SNPs: G7395A, G12390C, T14215C, T35587C, and G35991A) in the AS3MT gene were shown to be related to inter-individual variation in the arsenic metabolism. Arsenic 6-13 arsenite methyltransferase Homo sapiens 54-59 18976679-1 2009 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite, and intronic single-nucleotide polymorphisms (SNPs: G7395A, G12390C, T14215C, T35587C, and G35991A) in the AS3MT gene were shown to be related to inter-individual variation in the arsenic metabolism. Arsenic 6-13 arsenite methyltransferase Homo sapiens 218-223 18588996-2 2008 Inter-individual variation in arsenic metabolism has been reported and recent studies demonstrate that 287T allele in human arsenic (+3 oxidation state) methyltransferase (AS3MT) increase the percentage of monomethylated arsenic in urine. Arsenic 30-37 arsenite methyltransferase Homo sapiens 124-170 18588996-2 2008 Inter-individual variation in arsenic metabolism has been reported and recent studies demonstrate that 287T allele in human arsenic (+3 oxidation state) methyltransferase (AS3MT) increase the percentage of monomethylated arsenic in urine. Arsenic 30-37 arsenite methyltransferase Homo sapiens 172-177 18588996-2 2008 Inter-individual variation in arsenic metabolism has been reported and recent studies demonstrate that 287T allele in human arsenic (+3 oxidation state) methyltransferase (AS3MT) increase the percentage of monomethylated arsenic in urine. Arsenic 124-131 arsenite methyltransferase Homo sapiens 172-177 17889916-3 2007 Recently, a single nucleotide polymorphism (SNPs; rs17885947, M287T (T860C)) in the AS3MT gene was shown to be related to enzyme activity and considered to be related to genetic susceptibility to arsenic. Arsenic 196-203 arsenite methyltransferase Homo sapiens 84-89 17850829-0 2008 Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile. Arsenic 72-79 arsenite methyltransferase Homo sapiens 44-49 17850829-3 2008 Coding and flanking regions of the human arsenic methyltransferase (AS3MT) gene have been analysed in 50 Chilean men exposed to arsenic. Arsenic 41-48 arsenite methyltransferase Homo sapiens 68-73 17850829-8 2008 Our results indicate that genetic polymorphisms in AS3MT contribute to inter-individual variation in arsenic biotransformation and, therefore, may contribute to inter-individual variations in risk of arsenic toxicity and arsenic carcinogenesis. Arsenic 101-108 arsenite methyltransferase Homo sapiens 51-56 18414634-2 2008 Metabolism of arsenic proceeds through sequential reduction and oxidative methylation being mediated by the following genes: purine nucleoside phosphorylase (PNP), arsenic (+3) methyltransferase (As3MT), glutathione S-transferase omega 1 (GSTO1), and omega 2 (GSTO2). Arsenic 14-21 arsenite methyltransferase Homo sapiens 196-201 18414634-3 2008 PNP functions as arsenate reductase; As3MT methylates inorganic arsenic and its metabolites; and both GSTO1 and GSTO2 reduce the metabolites. Arsenic 64-71 arsenite methyltransferase Homo sapiens 37-42 18334919-3 2008 Thus, genetic variations in the AS3MT gene could explain, at least partly, the interindividual variation in the response to arsenic exposure. Arsenic 124-131 arsenite methyltransferase Homo sapiens 32-37 18334919-4 2008 In an earlier study, we have demonstrated that the AS3MT Met(287)Thr (C/T) polymorphism affected the urinary arsenic profile in a Chilean group of men (n=50) occupationally exposed to arsenic. Arsenic 109-116 arsenite methyltransferase Homo sapiens 51-56 18334919-4 2008 In an earlier study, we have demonstrated that the AS3MT Met(287)Thr (C/T) polymorphism affected the urinary arsenic profile in a Chilean group of men (n=50) occupationally exposed to arsenic. Arsenic 184-191 arsenite methyltransferase Homo sapiens 51-56 17306849-5 2007 Subsequent analyses revealed that the high D/M values associated with variant AS3MT alleles were primarily due to lower levels of monomethylarsonic acid as percent of total urinary arsenic (%MMA5). Arsenic 181-188 arsenite methyltransferase Homo sapiens 78-83 17306849-6 2007 In light of several reports of arsenic-induced disease being associated with relatively high %MMA5 levels, these findings raise the possibility that variant AS3MT individuals may suffer less risk from arsenic exposure than non-variant individuals. Arsenic 31-38 arsenite methyltransferase Homo sapiens 157-162 17306849-6 2007 In light of several reports of arsenic-induced disease being associated with relatively high %MMA5 levels, these findings raise the possibility that variant AS3MT individuals may suffer less risk from arsenic exposure than non-variant individuals. Arsenic 201-208 arsenite methyltransferase Homo sapiens 157-162