PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22197475-6 2012 The ATP-binding cassette (ABC) transporter proteins, multidrug resistance protein 1 (MRP1/ABCC1) and the related protein MRP2 (ABCC2), are thought to play an important role in arsenic detoxification through the cellular efflux of arsenic-GSH conjugates. Arsenic 176-183 ATP binding cassette subfamily C member 1 Homo sapiens 85-89 25258480-7 2014 The complex structure revealed the mode of arsenic binding efficiency with the receptor aquaporine 9 and ABCC1 channel protein. Arsenic 43-50 ATP binding cassette subfamily C member 1 Homo sapiens 105-110 24870404-6 2014 Human multidrug resistance protein 1 (MRP1/ABCC1) and MRP2 (ABCC2) are established arsenic efflux pumps, but unlike the related MRP4 (ABCC4) are not present at the basolateral membrane of hepatocytes. Arsenic 83-90 ATP binding cassette subfamily C member 1 Homo sapiens 38-42 24870404-6 2014 Human multidrug resistance protein 1 (MRP1/ABCC1) and MRP2 (ABCC2) are established arsenic efflux pumps, but unlike the related MRP4 (ABCC4) are not present at the basolateral membrane of hepatocytes. Arsenic 83-90 ATP binding cassette subfamily C member 1 Homo sapiens 43-48 23052202-0 2013 Multidrug resistance protein 1 (ABCC1) confers resistance to arsenic compounds in human myeloid leukemic HL-60 cells. Arsenic 61-68 ATP binding cassette subfamily C member 1 Homo sapiens 32-37 22197475-6 2012 The ATP-binding cassette (ABC) transporter proteins, multidrug resistance protein 1 (MRP1/ABCC1) and the related protein MRP2 (ABCC2), are thought to play an important role in arsenic detoxification through the cellular efflux of arsenic-GSH conjugates. Arsenic 176-183 ATP binding cassette subfamily C member 1 Homo sapiens 90-95 22197475-6 2012 The ATP-binding cassette (ABC) transporter proteins, multidrug resistance protein 1 (MRP1/ABCC1) and the related protein MRP2 (ABCC2), are thought to play an important role in arsenic detoxification through the cellular efflux of arsenic-GSH conjugates. Arsenic 230-237 ATP binding cassette subfamily C member 1 Homo sapiens 85-89 22197475-6 2012 The ATP-binding cassette (ABC) transporter proteins, multidrug resistance protein 1 (MRP1/ABCC1) and the related protein MRP2 (ABCC2), are thought to play an important role in arsenic detoxification through the cellular efflux of arsenic-GSH conjugates. Arsenic 230-237 ATP binding cassette subfamily C member 1 Homo sapiens 90-95 21918036-12 2011 These results suggest that MRP1 is an important cellular protective pathway for the highly toxic MMA(III) and have implications for environmental and clinical exposure to arsenic. Arsenic 171-178 ATP binding cassette subfamily C member 1 Homo sapiens 27-31 18365053-8 2003 The human MRP1, a member of this family, is frequently amplified in cancer cells and it is well-documented that MRPl-overexpressing cells poorly accumulate arsenic and antimony because of enhanced cellular effiux which depends on the presence of GSH. Arsenic 156-163 ATP binding cassette subfamily C member 1 Homo sapiens 10-14 15161912-0 2004 Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Arsenic 0-7 ATP binding cassette subfamily C member 1 Homo sapiens 63-67 15161912-0 2004 Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Arsenic 0-7 ATP binding cassette subfamily C member 1 Homo sapiens 68-73 15161912-4 2004 MRP1 also confers resistance to arsenic in association with GSH; however, the mechanism and the species of arsenic transported are unknown. Arsenic 32-39 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 15161912-4 2004 MRP1 also confers resistance to arsenic in association with GSH; however, the mechanism and the species of arsenic transported are unknown. Arsenic 107-114 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 15161912-13 2004 As(GS)(3) transport experiments using MRP1 mutants with substrate specificities differing from wild-type MRP1 suggested a commonality in the substrate binding pockets of As(GS)(3) and leukotriene C(4). Arsenic 0-2 ATP binding cassette subfamily C member 1 Homo sapiens 38-42 15161912-13 2004 As(GS)(3) transport experiments using MRP1 mutants with substrate specificities differing from wild-type MRP1 suggested a commonality in the substrate binding pockets of As(GS)(3) and leukotriene C(4). Arsenic 0-2 ATP binding cassette subfamily C member 1 Homo sapiens 105-109 19513507-4 2009 Three ABC transporter proteins, ABCB1, ABCC1 and ABCC2, were expressed increasingly and differently in two arsenic-resistant cell lines. Arsenic 107-114 ATP binding cassette subfamily C member 1 Homo sapiens 39-44 12387749-9 2002 Arsenic tolerance was also abolished by treatment with inhibitors of the Mdr1 and Mrp1 transporters, although no increases in mdr1 or mrp1 gene expression were observed. Arsenic 0-7 ATP binding cassette subfamily C member 1 Homo sapiens 82-86 12387749-10 2002 Our results indicate that this tolerance in human cells involves increases in GSH levels and GST activity that allow for more efficient arsenic efflux by MRP1 and MDR1. Arsenic 136-143 ATP binding cassette subfamily C member 1 Homo sapiens 154-158 12018890-0 2002 The MRP1-mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation. Arsenic 30-37 ATP binding cassette subfamily C member 1 Homo sapiens 4-8 10648417-0 2000 Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Arsenic 0-7 ATP binding cassette subfamily C member 1 Homo sapiens 119-122 11331074-1 2001 The human multidrug-resistance protein (MRP1) confers resistance to some heavy metals such as arsenic and antimony, mainly through mediating an increased cellular efflux of metal. Arsenic 94-101 ATP binding cassette subfamily C member 1 Homo sapiens 40-44 10555748-7 1999 Multidrug-resistant cancer cells that were cross-resistant to arsenic contained higher levels of GSH or multidrug-resistance-associated protein 1 than their drug-sensitive parental cells. Arsenic 62-69 ATP binding cassette subfamily C member 1 Homo sapiens 104-145 10685512-7 2000 In conclusion, these findings demonstrated that MRP1 likely handled some, but not all, cytotoxic metals such as arsenic and mercuric ions in addition to antimony, therefore resulting in reduced toxicity of these compounds towards MRP1-overexpressing cells. Arsenic 112-119 ATP binding cassette subfamily C member 1 Homo sapiens 48-52 10685512-7 2000 In conclusion, these findings demonstrated that MRP1 likely handled some, but not all, cytotoxic metals such as arsenic and mercuric ions in addition to antimony, therefore resulting in reduced toxicity of these compounds towards MRP1-overexpressing cells. Arsenic 112-119 ATP binding cassette subfamily C member 1 Homo sapiens 230-234 29752257-10 2018 Efflux of different arsenic metabolites by MRP1 is likely influenced by multiple factors, including cell and tissue type. Arsenic 20-27 ATP binding cassette subfamily C member 1 Homo sapiens 43-47 31355259-10 2019 Taken together, these results prove that PC can promote arsenic methylation metabolism and efflux in L-02 cells, which may be related to the upregulation of GSH, MRP1, and AS3MT levels by PC. Arsenic 56-63 ATP binding cassette subfamily C member 1 Homo sapiens 162-166 29951962-3 2019 The majority of ABC family members (including ABCB1 and ABCC1) are reported to play a role in the development of arsenic and drug resistance in mammals. Arsenic 113-120 ATP binding cassette subfamily C member 1 Homo sapiens 56-61 29951962-6 2019 The arsenic resistance capacity of ABCC1 was the strongest among the three genes, while those of ABCA1 and ABCB1 were similar. Arsenic 4-11 ATP binding cassette subfamily C member 1 Homo sapiens 35-40 29951962-7 2019 Double or triple gene knockdown of ABCA1, ABCB1, and ABCC1 via RNA interference led to a decrease significant in arsenic resistance when ABCA1/ABCB1 or ABCB1/ABCC1 were simultaneously silenced. Arsenic 113-120 ATP binding cassette subfamily C member 1 Homo sapiens 53-58 29951962-7 2019 Double or triple gene knockdown of ABCA1, ABCB1, and ABCC1 via RNA interference led to a decrease significant in arsenic resistance when ABCA1/ABCB1 or ABCB1/ABCC1 were simultaneously silenced. Arsenic 113-120 ATP binding cassette subfamily C member 1 Homo sapiens 158-163 29752257-0 2018 Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Cellular Protection and Transport of Methylated Arsenic Metabolites Differs between Human Cell Lines. Arsenic 101-108 ATP binding cassette subfamily C member 1 Homo sapiens 32-36 29752257-0 2018 Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Cellular Protection and Transport of Methylated Arsenic Metabolites Differs between Human Cell Lines. Arsenic 101-108 ATP binding cassette subfamily C member 1 Homo sapiens 37-42 29752257-1 2018 The ATP-binding cassette (ABC) transporter multidrug resistance protein 1 (MRP1/ABCC1) protects cells from arsenic (a proven human carcinogen) through the cellular efflux of arsenic triglutathione [As(GS)3] and the diglutathione conjugate of monomethylarsonous acid [MMA(GS)2]. Arsenic 107-114 ATP binding cassette subfamily C member 1 Homo sapiens 75-79 29752257-1 2018 The ATP-binding cassette (ABC) transporter multidrug resistance protein 1 (MRP1/ABCC1) protects cells from arsenic (a proven human carcinogen) through the cellular efflux of arsenic triglutathione [As(GS)3] and the diglutathione conjugate of monomethylarsonous acid [MMA(GS)2]. Arsenic 107-114 ATP binding cassette subfamily C member 1 Homo sapiens 80-85 29752257-4 2018 MRP1 expressed in HEK293 cells reduced the toxicity of the major urinary arsenic metabolite dimethylarsinic acid (DMAV), and HEK-WT-MRP1-enriched vesicles transported DMAV with high apparent affinity and capacity (Km 0.19 microM, Vmax 342 pmol mg-1protein min-1). Arsenic 73-80 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 29752257-11 2018 This could have implications for the impact of MRP1 on both tissue-specific susceptibility to arsenic-induced disease and tumor sensitivity to arsenic-based therapeutics. Arsenic 94-101 ATP binding cassette subfamily C member 1 Homo sapiens 47-51 26031227-4 2015 MRP1 expression was significantly decreased in those with arsenic urinary levels >50 mug/L when compared with the controls. Arsenic 58-65 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 27736728-5 2016 We compared the arsenic sensitivity, and the expression and responses to arsenic of the arsenic-related transporters, MRP1, MRP2, and ASNA1, in paired parent/arsenic-resistant HL-60/RS/HL-60 and arsenic-sensitive/parental K562/ADM/K562 cells. Arsenic 73-80 ATP binding cassette subfamily C member 1 Homo sapiens 118-122 27736728-5 2016 We compared the arsenic sensitivity, and the expression and responses to arsenic of the arsenic-related transporters, MRP1, MRP2, and ASNA1, in paired parent/arsenic-resistant HL-60/RS/HL-60 and arsenic-sensitive/parental K562/ADM/K562 cells. Arsenic 73-80 ATP binding cassette subfamily C member 1 Homo sapiens 118-122 27736728-5 2016 We compared the arsenic sensitivity, and the expression and responses to arsenic of the arsenic-related transporters, MRP1, MRP2, and ASNA1, in paired parent/arsenic-resistant HL-60/RS/HL-60 and arsenic-sensitive/parental K562/ADM/K562 cells. Arsenic 73-80 ATP binding cassette subfamily C member 1 Homo sapiens 118-122 27736728-8 2016 In conclusion, the cross-resistance of conventional chemotherapeutics-resistant leukemic cells to arsenic trioxide is determined by both levels of MRP1, MRP2, and ASNA1, and also by the responses of these transporters to arsenic stress. Arsenic 98-105 ATP binding cassette subfamily C member 1 Homo sapiens 147-151 27297967-0 2016 Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23. Arsenic 24-26 ATP binding cassette subfamily C member 1 Homo sapiens 78-82 27297967-0 2016 Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23. Arsenic 24-26 ATP binding cassette subfamily C member 1 Homo sapiens 83-88 27297967-2 2016 Arsenic, a human carcinogen, is a high-affinity MRP1 substrate as arsenic triglutathione [As(GS)3]. Arsenic 0-7 ATP binding cassette subfamily C member 1 Homo sapiens 48-52 26031227-0 2015 MRP1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic. Arsenic 109-116 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 26031227-2 2015 The aim of this study was to evaluate and compare the expression of MRP1 in bronchoalveolar cells from subjects with and without lung cancer who had been chronically exposed to arsenic through drinking water. Arsenic 177-184 ATP binding cassette subfamily C member 1 Homo sapiens 68-72 26970057-0 2016 Influence of MRP1 G1666A and GSTP1 Ile105Val genetic variants on the urinary and blood arsenic levels of Turkish smelter workers. Arsenic 87-94 ATP binding cassette subfamily C member 1 Homo sapiens 13-17 26970057-2 2016 The effect of MRP1 G1666A and GSTP1 Ile105Val polymorphisms on blood and urinary arsenic levels were determined in 95 Turkish smelter workers. Arsenic 81-88 ATP binding cassette subfamily C member 1 Homo sapiens 14-18 26970057-5 2016 A significant association between MRP1 1666A allele and urinary arsenic levels was found (p=0.001). Arsenic 64-71 ATP binding cassette subfamily C member 1 Homo sapiens 34-38 26970057-8 2016 This study suggested that MRP1 G1666A alone and, also, combined with GSTP1 Ile105Val were associated with inter-individual variations in urinary arsenic levels, but not with blood arsenic levels. Arsenic 145-152 ATP binding cassette subfamily C member 1 Homo sapiens 26-30 26031227-5 2015 In conclusion, chronic arsenic exposure negatively correlates with the expression of MRP1 in BAL cells in patients with lung cancer. Arsenic 23-30 ATP binding cassette subfamily C member 1 Homo sapiens 85-89 25752797-8 2015 Basolateral transport of arsenic was temperature- and GSH-dependent and inhibited by the MRP inhibitor MK-571. Arsenic 25-32 ATP binding cassette subfamily C member 1 Homo sapiens 89-92 25485709-8 2015 The transport genes, Abcc1 and Abcc2 were increased by arsenic in WT cells but either showed no or very limited increases in MT-null cells. Arsenic 55-62 ATP binding cassette subfamily C member 1 Homo sapiens 21-26