PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26773055-5 2016 Here we show that accumulation of unrepaired SSBs triggers a p53/Sp1-dependent downregulation of APE1, the endonuclease responsible for the DNA incision during BER. ssbs 45-49 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 97-101 15647512-7 2005 Conversely, APE1 overproduction resulted in a 3-fold increase in the sensitivity of XRCC1-deficient cells to an alkylating agent, most probably due to the accumulation of SSBs. ssbs 171-175 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 12-16