PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25808897-3 2015 In some recent investigations, peroxisome proliferator activated receptor gamma coactivator 1 alpha mediated mitochondrial biogenesis and its ability to restore reactive oxygen species-detoxifying enzymes have been observed in preclinical studies. oxygen species 170-184 PPARG coactivator 1 alpha Homo sapiens 31-99 34748911-2 2021 As an effective lifestyle intervention, exercise induces extensive mitochondrial adaptations through vascular mechanical stress and the increased production and release of reactive oxygen species and nitric oxide that activate multiple intracellular signaling pathways, among which peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) plays a critical role. oxygen species 181-195 PPARG coactivator 1 alpha Homo sapiens 282-349 34748911-2 2021 As an effective lifestyle intervention, exercise induces extensive mitochondrial adaptations through vascular mechanical stress and the increased production and release of reactive oxygen species and nitric oxide that activate multiple intracellular signaling pathways, among which peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) plays a critical role. oxygen species 181-195 PPARG coactivator 1 alpha Homo sapiens 351-361