PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27785023-5	2016	A series of studies on the action mechanism showed that the polymer components such as beta-cyclodextrin, hydrophobic poly(d,l-lactide) segment, and poly(ethylene glycol) coordinatively contributed to the improved intracellular ATP depletion and ATPase activity, increased intracellular uptake of P-gp substrates via competitive binding to P-gp, and decreased P-gp expression in MCF-7/ADR cells.	betadex	87-104	ATP binding cassette subfamily B member 1	Homo sapiens	297-301	
29343452-5	2018	Further studies on the mechanism in increasing uptake efficiency showed that R8-CM-beta-CD was internalized via different styles of endocytosis and could inhibit P-glycoprotein (P-gp) efflux pumps.	betadex	82-90	ATP binding cassette subfamily B member 1	Homo sapiens	162-176	
29343452-5	2018	Further studies on the mechanism in increasing uptake efficiency showed that R8-CM-beta-CD was internalized via different styles of endocytosis and could inhibit P-glycoprotein (P-gp) efflux pumps.	betadex	82-90	ATP binding cassette subfamily B member 1	Homo sapiens	178-182	
27785023-5	2016	A series of studies on the action mechanism showed that the polymer components such as beta-cyclodextrin, hydrophobic poly(d,l-lactide) segment, and poly(ethylene glycol) coordinatively contributed to the improved intracellular ATP depletion and ATPase activity, increased intracellular uptake of P-gp substrates via competitive binding to P-gp, and decreased P-gp expression in MCF-7/ADR cells.	betadex	87-104	ATP binding cassette subfamily B member 1	Homo sapiens	340-344	
27785023-5	2016	A series of studies on the action mechanism showed that the polymer components such as beta-cyclodextrin, hydrophobic poly(d,l-lactide) segment, and poly(ethylene glycol) coordinatively contributed to the improved intracellular ATP depletion and ATPase activity, increased intracellular uptake of P-gp substrates via competitive binding to P-gp, and decreased P-gp expression in MCF-7/ADR cells.	betadex	87-104	ATP binding cassette subfamily B member 1	Homo sapiens	340-344	
23215690-1	2013	OBJECTIVES: This study aimed to evaluate the potential of solid lipid nanoparticles (SLNs) of paclitaxel (PTX) modified with a 2-hydroxypropyl-beta-cyclodextrin system to enhance cellular accumulation of PTX into p-glycoprotein (p-gp)-expressing cells.	betadex	143-160	ATP binding cassette subfamily B member 1	Homo sapiens	213-227	
27088190-0	2016	Mechanism study of PEGylated polyester and beta-cyclodextrin integrated micelles on drug resistance reversal in MRP1-overexpressed HL60/ADR cells.	betadex	43-60	ATP binding cassette subfamily B member 1	Homo sapiens	112-116	
23215690-1	2013	OBJECTIVES: This study aimed to evaluate the potential of solid lipid nanoparticles (SLNs) of paclitaxel (PTX) modified with a 2-hydroxypropyl-beta-cyclodextrin system to enhance cellular accumulation of PTX into p-glycoprotein (p-gp)-expressing cells.	betadex	143-160	ATP binding cassette subfamily B member 1	Homo sapiens	229-233	
22243797-3	2012	In this study, two CdSe/ZnSe QDs modified with beta-CD coupled to L-Arg or L-His were used to simultaneously deliver doxorubicin (Dox) and siRNA targeting the MDR1 gene to reverse the multidrug resistance of HeLa cells.	betadex	47-54	ATP binding cassette subfamily B member 1	Homo sapiens	159-163	
22243797-4	2012	In this co-delivery system, Dox was firstly encapsulated into the hydrophobic cavities of beta-CD, resulting in bypass of P-glycoprotein (P-gp)-mediated drug efflux.	betadex	90-97	ATP binding cassette subfamily B member 1	Homo sapiens	122-136	
22243797-4	2012	In this co-delivery system, Dox was firstly encapsulated into the hydrophobic cavities of beta-CD, resulting in bypass of P-glycoprotein (P-gp)-mediated drug efflux.	betadex	90-97	ATP binding cassette subfamily B member 1	Homo sapiens	138-142	
34528148-4	2021	beta-Cyclodextrin and light green SF yellowish were identified as modest inhibitors of P-gp with IC50 values of 168 muM (95% CI, 118-251 muM) and 204 muM (95% CI, 5.9-1745 muM), respectively.	betadex	0-17	ATP binding cassette subfamily B member 1	Homo sapiens	87-91	
15139519-1	2004	PURPOSE: The purpose of this study is to reveal the contribution of membrane components to the inhibitory effect of 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-CyD) on P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2) function in vinblastine-resistant Caco-2 (Caco-2R) cell monolayers.	betadex	131-149	ATP binding cassette subfamily B member 1	Homo sapiens	167-181	
15139519-1	2004	PURPOSE: The purpose of this study is to reveal the contribution of membrane components to the inhibitory effect of 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-CyD) on P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2) function in vinblastine-resistant Caco-2 (Caco-2R) cell monolayers.	betadex	131-149	ATP binding cassette subfamily B member 1	Homo sapiens	183-187	
15139519-6	2004	RESULTS: Of various beta-cyclodextrin derivatives (beta-CyDs), DM-beta-CyD most significantly impaired the efflux function of P-gp and MRP2 without changing cell viability and membrane integrity.	betadex	20-37	ATP binding cassette subfamily B member 1	Homo sapiens	126-130	
30039475-2	2019	Herein, the mRNA-cleaving DNAzyme that targets the mRNA of MDR1 gene in doxorubicin-resistant breast cancer cell line (MCF-7/DR) loaded on the chitosan beta-cyclodextrin complexes was used as a tropical agent.	betadex	152-169	ATP binding cassette subfamily B member 1	Homo sapiens	59-63