PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19205364-13 2008 In vitro valproate inhibits TNFa and IL-6 production, whereas in epileptic patients this drug enhances IL-1, IL-6 and IL-5 concentration. Valproic Acid 9-18 tumor necrosis factor Homo sapiens 28-32 21543053-0 2011 Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-alpha from activated astrocytes. Valproic Acid 0-13 tumor necrosis factor Homo sapiens 89-116 21866484-8 2011 In vitro and in vivo experiments show that antiepileptic drugs could affect cytokine levels (e.g. valproate significantly inhibited production of TNF- alpha and IL-6 by human monocytic leukaemia cells). Valproic Acid 98-107 tumor necrosis factor Homo sapiens 146-156 21866484-9 2011 In epilepsy patients studies (including ex vivo) show elevated levels of IL-1 beta, IL-2, IL-5, IL-6 or TNF- alpha after carbamazepine, valproic acid and phenytoin. Valproic Acid 136-149 tumor necrosis factor Homo sapiens 104-114 17675290-3 2007 We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin. Valproic Acid 78-91 tumor necrosis factor Homo sapiens 247-280 29196891-11 2018 The anti-inflammatory cytokines (IL-10 and TGF-beta1) were overproduced while TNF-alpha level was decreased in response to VPA. Valproic Acid 123-126 tumor necrosis factor Homo sapiens 78-87 33812975-7 2021 CV-S NPs show superior potential to free VPA to suppress the TLR - MyD88 - NF-kappaB signalling axis, leading to decreased TNF-alpha expression and secretion. Valproic Acid 41-44 tumor necrosis factor Homo sapiens 123-132 10700573-0 2000 Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB. Valproic Acid 0-16 tumor necrosis factor Homo sapiens 40-49 10700573-8 2000 VPA significantly inhibited LPS-induced production of TNF-alpha and IL-6 by THP-1 cells, whereas other AEDs did not. Valproic Acid 0-3 tumor necrosis factor Homo sapiens 54-63 10700573-9 2000 The findings are consistent with the idea that VPA suppresses TNF-alpha and IL-6 production via inhibition of NF-kappaB activation. Valproic Acid 47-50 tumor necrosis factor Homo sapiens 62-71 10424764-0 1999 Cytotoxicity induced by the combination of valproic acid and tumor necrosis factor-alpha: implication for valproic acid-associated hepatotoxicity syndrome. Valproic Acid 106-119 tumor necrosis factor Homo sapiens 61-88 34630611-8 2021 After treatment, the levels of NSE, MBP, TNF-alpha, and IL-6 in the two groups decreased, and the levels of BDNF increased, and the LEV group changed significantly compared with the VPA group (P < 0.05). Valproic Acid 182-185 tumor necrosis factor Homo sapiens 41-50 34635175-11 2021 The production of inflammatory cytokines (TNF-alpha and IL-6) induced by TNF-alpha and SARS-CoV-2 infection is diminished in the presence of VPA. Valproic Acid 141-144 tumor necrosis factor Homo sapiens 42-51 34635175-11 2021 The production of inflammatory cytokines (TNF-alpha and IL-6) induced by TNF-alpha and SARS-CoV-2 infection is diminished in the presence of VPA. Valproic Acid 141-144 tumor necrosis factor Homo sapiens 73-82 27639185-5 2017 VPA and lithium both induce significant down-regulation of group I CD1 expression and secretion of IL-6 during differentiation of human monocyte-derived immature DC, while they differ in the induction of CD83 and CD86 expression, secretion of IL-8, IL-10, and TNF-alpha. Valproic Acid 0-3 tumor necrosis factor Homo sapiens 260-269 32750425-3 2020 Although one study has showed that the anti-epileptic drug valproic acid (VPA) could sensitize transforming growth factor-beta (TGF-beta)-induced sorafenib-resistant HCC cells, it is unclear whether VPA could reverse resistance to long-term clinical treatment with sorafenib. Valproic Acid 59-72 tumor necrosis factor Homo sapiens 95-126 32750425-3 2020 Although one study has showed that the anti-epileptic drug valproic acid (VPA) could sensitize transforming growth factor-beta (TGF-beta)-induced sorafenib-resistant HCC cells, it is unclear whether VPA could reverse resistance to long-term clinical treatment with sorafenib. Valproic Acid 74-77 tumor necrosis factor Homo sapiens 95-126 31785814-5 2020 Interestingly, the combination treatment of VPA and anti-PD-L1 antibody activated IRF1/IRF8 transcriptional axis in MDSCs leading to blockade of their immunosuppressive function by downregulating the expression of IL-10, IL-6, and ARG1 while re-activating CD8+ T-cells for the production of TNFalpha to further enhance anti-tumor immunity. Valproic Acid 44-47 tumor necrosis factor Homo sapiens 291-299 25443723-0 2014 Concentration of Il-1beta, Il-2, Il-6, TNFalpha in the blood serum in children with generalized epilepsy treated by valproate. Valproic Acid 116-125 tumor necrosis factor Homo sapiens 39-47 32262458-7 2015 In a whole-blood model of inflammation all DP and VA doped CPs retained their bioactivity, causing a significant reduction in levels of the pro-inflammatory cytokine TNF-alpha. Valproic Acid 50-52 tumor necrosis factor Homo sapiens 166-175 24742998-4 2014 METHODS AND RESULTS: We showed that VPA inhibited the production of IFN-alpha and the proinflammatory cytokines TNF-alpha and IL-6 by CpG-activated PDC. Valproic Acid 36-39 tumor necrosis factor Homo sapiens 112-121 24717258-8 2014 Tumor necrosis factor alpha levels were significantly lower in the VPA + memantine group than in the VPA + placebo group (P = 0.013). Valproic Acid 67-70 tumor necrosis factor Homo sapiens 0-27 24717258-8 2014 Tumor necrosis factor alpha levels were significantly lower in the VPA + memantine group than in the VPA + placebo group (P = 0.013). Valproic Acid 101-104 tumor necrosis factor Homo sapiens 0-27 24717258-11 2014 Treating bipolar II depression with VPA + memantine may improve the plasma TNF-alpha level. Valproic Acid 36-39 tumor necrosis factor Homo sapiens 75-84 24757498-2 2014 Recent in vitro and animal studies of valproic acid (VPA) report antioxidative and anti-inflammatory properties, and suppression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. Valproic Acid 38-51 tumor necrosis factor Homo sapiens 155-188 24757498-2 2014 Recent in vitro and animal studies of valproic acid (VPA) report antioxidative and anti-inflammatory properties, and suppression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. Valproic Acid 53-56 tumor necrosis factor Homo sapiens 155-188