PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34282726-3 2021 Here we test the hypothesis that chronically elevated MMP-9 activity during early neurodevelopment is responsible for neural circuit hyperconnectivity observed in Xenopus tadpoles after early exposure to valproic acid (VPA), a known teratogen associated with ND in humans. Valproic Acid 204-217 matrix metallopeptidase 9 gene 2 L homeolog Xenopus laevis 54-59 34282726-3 2021 Here we test the hypothesis that chronically elevated MMP-9 activity during early neurodevelopment is responsible for neural circuit hyperconnectivity observed in Xenopus tadpoles after early exposure to valproic acid (VPA), a known teratogen associated with ND in humans. Valproic Acid 219-222 matrix metallopeptidase 9 gene 2 L homeolog Xenopus laevis 54-59 34282726-5 2021 We found that overexpressing MMP-9 in the brain copies effects of VPA on synaptic connectivity, and blocking MMP-9 activity pharmacologically or genetically reverses effects of VPA on physiology and behavior. Valproic Acid 66-69 matrix metallopeptidase 9 gene 2 L homeolog Xenopus laevis 29-34 34282726-5 2021 We found that overexpressing MMP-9 in the brain copies effects of VPA on synaptic connectivity, and blocking MMP-9 activity pharmacologically or genetically reverses effects of VPA on physiology and behavior. Valproic Acid 177-180 matrix metallopeptidase 9 gene 2 L homeolog Xenopus laevis 109-114