PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3933372-0 1985 Effect of serum albumin on free fractions of phenobarbital and valproic acid in patients with convulsive seizures. Valproic Acid 63-76 albumin Homo sapiens 16-23 2498075-1 1989 Addition of sodium valproate (VPA) to a buffered solution of human serum albumin (HSA) or to serum reduces binding affinity for palmitate. Valproic Acid 12-28 albumin Homo sapiens 67-86 2498075-1 1989 Addition of sodium valproate (VPA) to a buffered solution of human serum albumin (HSA) or to serum reduces binding affinity for palmitate. Valproic Acid 30-33 albumin Homo sapiens 67-86 16918714-11 2006 Co-medication with valproic acid and carbamazepine led to a 52.5% and 38.5% increase of the free fraction of phenytoin, respectively, and a 10 g/l decrease of serum albumin to a 15.1% increase of the free fraction of phenytoin. Valproic Acid 19-32 albumin Homo sapiens 159-172 369855-0 1979 Valproic acid binding to human serum albumin and determination of free fraction in the presence of anticonvulsants and free fatty acids. Valproic Acid 0-13 albumin Homo sapiens 31-44 369855-1 1979 The interaction between valproic acid (VPA) and human serum albumin (HSA) was investigated using the equilibrium dialysis technique under various conditions. Valproic Acid 24-37 albumin Homo sapiens 54-73 369855-1 1979 The interaction between valproic acid (VPA) and human serum albumin (HSA) was investigated using the equilibrium dialysis technique under various conditions. Valproic Acid 39-42 albumin Homo sapiens 54-73 33111212-6 2021 Our results demonstrate that MSCs differentiate into hepatic-like cells when treated with 5 mM VPA for 24 h. The VPA-treated MSCs have shown significant upregulation in the expression of hepatic genes, CK-18 (P < 0.05), TAT (P < 0.01), and AFP (P < 0.001), and hepatic proteins, AFP (P < 0.05) and ALB (P < 0.01). Valproic Acid 95-98 albumin Homo sapiens 298-301 33111212-6 2021 Our results demonstrate that MSCs differentiate into hepatic-like cells when treated with 5 mM VPA for 24 h. The VPA-treated MSCs have shown significant upregulation in the expression of hepatic genes, CK-18 (P < 0.05), TAT (P < 0.01), and AFP (P < 0.001), and hepatic proteins, AFP (P < 0.05) and ALB (P < 0.01). Valproic Acid 113-116 albumin Homo sapiens 298-301 33055270-1 2021 OBJECTIVE: To test the accuracy of an equation in adult patients with status epilepticus (SE) that calculates the free concentration of serum valproic acid (fVPA) from the total concentration of serum VPA (tVPA) and serum albumin. Valproic Acid 142-155 albumin Homo sapiens 216-229 23658825-4 2013 VPA treatment also significantly enhanced the hepatic functions of the differentiated cells, including glycogen storage, cytochrome P450 activity, AFP and ALB synthesis, and urea production. Valproic Acid 0-3 albumin Homo sapiens 155-158 6424277-0 1984 Valproic acid binding to human serum albumin and human plasma: effects of pH variation and buffer composition in equilibrium dialysis. Valproic Acid 0-13 albumin Homo sapiens 31-44 6424277-1 1984 The binding of valproic acid (VPA) to human serum albumin (HSA) and to pooled human plasma has been investigated by using equilibrium dialysis with three different dialysis solutions: phosphate buffer (solution I), Krebs solution (solution II), and Krebs solution without calcium (solution III). Valproic Acid 15-28 albumin Homo sapiens 44-63 6424277-1 1984 The binding of valproic acid (VPA) to human serum albumin (HSA) and to pooled human plasma has been investigated by using equilibrium dialysis with three different dialysis solutions: phosphate buffer (solution I), Krebs solution (solution II), and Krebs solution without calcium (solution III). Valproic Acid 30-33 albumin Homo sapiens 44-63 32978045-0 2021 Factors to influence the accuracy of albumin adjusted free valproic acid concentration. Valproic Acid 59-72 albumin Homo sapiens 37-44 32978045-3 2021 Based on the highly protein-bound characteristics of VPA, an albumin-adjusted formula has been proposed to predict free VPA concentration (PfVPA). Valproic Acid 53-56 albumin Homo sapiens 61-68 32978045-3 2021 Based on the highly protein-bound characteristics of VPA, an albumin-adjusted formula has been proposed to predict free VPA concentration (PfVPA). Valproic Acid 120-123 albumin Homo sapiens 61-68 30328046-0 2019 Accuracy of Valproic Acid Concentration Correction Based on Serum Albumin. Valproic Acid 12-25 albumin Homo sapiens 66-73 8243440-0 1993 Valproate and palmitate binding to serum albumin in valproate-treated patients. Valproic Acid 0-9 albumin Homo sapiens 41-48 8946661-1 1996 Valproic acid is an anticonvulsant that is strongly bound to serum albumin. Valproic Acid 0-13 albumin Homo sapiens 61-74 9514615-3 1998 Mutual displacement experiments indicated that furosemide and valproic acid share a common high affinity binding site on human serum albumin (HSA). Valproic Acid 62-75 albumin Homo sapiens 127-140 8243440-2 1993 Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. Valproic Acid 11-20 albumin Homo sapiens 38-51 8243440-0 1993 Valproate and palmitate binding to serum albumin in valproate-treated patients. Valproic Acid 52-61 albumin Homo sapiens 41-48 2111005-0 1990 Valproate and palmitate binding to human serum albumin: an hypothesis on obesity. Valproic Acid 0-9 albumin Homo sapiens 41-54 2111005-1 1990 Binding equilibria of valproate (2-n-propyl-pentanoic acid anion) with defatted human serum albumin were studied by equilibrium dialysis in a 66 mM sodium phosphate buffer, pH 7.4, 37 degrees. Valproic Acid 22-31 albumin Homo sapiens 92-99 2111005-3 1990 It was found that the best fit resulted from a model in which 67% of the albumin was capable of binding valproate, whereas 33% did not bind. Valproic Acid 104-113 albumin Homo sapiens 73-80 2111005-5 1990 The binding albumin component combines with three molecules of valproate with high affinity and with at least seven additional molecules that are loosely bound. Valproic Acid 63-72 albumin Homo sapiens 12-19 2111005-7 1990 At very high concentrations of free valproate (above 10 mM) irreversible changes in the albumin take place, resulting in poor reproducibility in the amount of bound valproate. Valproic Acid 36-45 albumin Homo sapiens 88-95 2111005-7 1990 At very high concentrations of free valproate (above 10 mM) irreversible changes in the albumin take place, resulting in poor reproducibility in the amount of bound valproate. Valproic Acid 165-174 albumin Homo sapiens 88-95 2111005-8 1990 In the presence of palmitate, 0.5, 1, and 1.5 mol/mol of albumin, binding of valproate is decreased by a competitive mechanism. Valproic Acid 77-86 albumin Homo sapiens 57-64