PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15927669-9 2005 The combination of DAC and VPA had a synergistic effect in terms of growth inhibition, induction of apoptosis and reactivation of p57KIP2 and p21CIP1. Valproic Acid 27-30 cyclin dependent kinase inhibitor 1A Homo sapiens 142-149 16373706-0 2005 Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. Valproic Acid 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 151-158 16373706-7 2005 With Western hybridization and real-time reverse transcription-PCR, we further showed that the antitumor activities of valproic acid correlated with induction of histone (H3 and H4) hyperacetylation, activation of p21, and suppression of TP53, CDK4, and CMYC expression. Valproic Acid 119-132 cyclin dependent kinase inhibitor 1A Homo sapiens 214-217 15870934-0 2005 p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells. Valproic Acid 83-96 cyclin dependent kinase inhibitor 1A Homo sapiens 8-12 15870934-6 2005 Moreover, we addressed the question of whether the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) are involved in the mechanism of action of members of the short-chain fatty acids class (VPA, sodium butyrate and tributyrin) of HDAC inhibitors, in human NB cells. Valproic Acid 199-202 cyclin dependent kinase inhibitor 1A Homo sapiens 86-89 15870934-8 2005 These results suggest that p21(Cip1) could be involved in the inhibition of proliferation and induction of differentiation in human NB cells induced by treatment with VPA or tributyrin or sodium butyrate. Valproic Acid 167-170 cyclin dependent kinase inhibitor 1A Homo sapiens 27-30 15870934-8 2005 These results suggest that p21(Cip1) could be involved in the inhibition of proliferation and induction of differentiation in human NB cells induced by treatment with VPA or tributyrin or sodium butyrate. Valproic Acid 167-170 cyclin dependent kinase inhibitor 1A Homo sapiens 31-35 33576217-6 2021 Previously, we reported the effect of valproic acid (VPA) and trichostatin A (TSA) on TSGs p21WAF1/CIP1 (p21), p27Kip1 (p27), and p57Kip2 (P57) and also HDAC1 in colon cancer. Valproic Acid 53-56 cyclin dependent kinase inhibitor 1A Homo sapiens 91-103 33576217-0 2021 Effect of Valproic Acid on the Class I Histone Deacetylase 1, 2 and 3, Tumor Suppressor Genes p21WAF1/CIP1 and p53, and Intrinsic Mitochondrial Apoptotic Pathway, Pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) Apoptotic Genes Expression, Cell Viability, and Apoptosis Induction in Hepatocellular Carcinoma HepG2 Cell Line. Valproic Acid 10-23 cyclin dependent kinase inhibitor 1A Homo sapiens 94-106 33576217-6 2021 Previously, we reported the effect of valproic acid (VPA) and trichostatin A (TSA) on TSGs p21WAF1/CIP1 (p21), p27Kip1 (p27), and p57Kip2 (P57) and also HDAC1 in colon cancer. Valproic Acid 38-51 cyclin dependent kinase inhibitor 1A Homo sapiens 91-103 33576217-6 2021 Previously, we reported the effect of valproic acid (VPA) and trichostatin A (TSA) on TSGs p21WAF1/CIP1 (p21), p27Kip1 (p27), and p57Kip2 (P57) and also HDAC1 in colon cancer. Valproic Acid 38-51 cyclin dependent kinase inhibitor 1A Homo sapiens 91-94 33576217-6 2021 Previously, we reported the effect of valproic acid (VPA) and trichostatin A (TSA) on TSGs p21WAF1/CIP1 (p21), p27Kip1 (p27), and p57Kip2 (P57) and also HDAC1 in colon cancer. Valproic Acid 53-56 cyclin dependent kinase inhibitor 1A Homo sapiens 91-94 33576217-10 2021 RESULTS: VPA downregulated class I histone deacetylase (HDAC) 1, 2, and 3, Bcl-2, Bcl-xL, and Mcl-1 and upregulated p21, p53, Bax, Bak, and Bim resulting in apoptosis induction. Valproic Acid 9-12 cyclin dependent kinase inhibitor 1A Homo sapiens 116-119 33576217-11 2021 CONCLUSION: VPA can induce apoptosis via activation of the intrinsic mitochondrial apoptotic pathway and also epigenetic reactivation of p21 and p53 through inhibition of class I HDAC 1, 2 and 3, activity.
. Valproic Acid 12-15 cyclin dependent kinase inhibitor 1A Homo sapiens 137-140 22968660-6 2013 We found that VPA and SBHA dramatically inhibited cell growth, induced a G1/S cell cycle block in accompany with an elevated level of P21(WAF1) protein in Nalm-6 cells. Valproic Acid 14-17 cyclin dependent kinase inhibitor 1A Homo sapiens 134-142 31516890-11 2019 Conclusion: 5-Aza-CdR, VPA, and TSA can significantly downregulate DNMT1 and HDAC1 and up-regulate p21, p27, and p57 genes expression through which enhance cell apoptosis and cell growth inhibition in colon cancer. Valproic Acid 23-26 cyclin dependent kinase inhibitor 1A Homo sapiens 99-102 21519790-11 2011 We found that VPA and TSA induce apoptosis, upregulate p21/Waf1/CIP1, repress TMPRSS2-ERG expression and affect acetylation status of p53 in VCaP cells. Valproic Acid 14-17 cyclin dependent kinase inhibitor 1A Homo sapiens 55-58 22303878-5 2012 Meanwhile, VPA and SBHA dramatically inhibited cell growth, blocked G2/M cell cycle progression and increased p21(WAF1) expression. Valproic Acid 11-14 cyclin dependent kinase inhibitor 1A Homo sapiens 110-113 22303878-5 2012 Meanwhile, VPA and SBHA dramatically inhibited cell growth, blocked G2/M cell cycle progression and increased p21(WAF1) expression. Valproic Acid 11-14 cyclin dependent kinase inhibitor 1A Homo sapiens 114-118 23093837-6 2012 RESULTS: VPA treatment causes cell cycle arrest in PCa cells in vivo, as determined by increase in p21 and p27 and decrease in cyclin D1 expression. Valproic Acid 9-12 cyclin dependent kinase inhibitor 1A Homo sapiens 99-102 21519790-11 2011 We found that VPA and TSA induce apoptosis, upregulate p21/Waf1/CIP1, repress TMPRSS2-ERG expression and affect acetylation status of p53 in VCaP cells. Valproic Acid 14-17 cyclin dependent kinase inhibitor 1A Homo sapiens 59-63 21519790-11 2011 We found that VPA and TSA induce apoptosis, upregulate p21/Waf1/CIP1, repress TMPRSS2-ERG expression and affect acetylation status of p53 in VCaP cells. Valproic Acid 14-17 cyclin dependent kinase inhibitor 1A Homo sapiens 64-68 19176032-9 2008 The p21(WAF1/CIP) protein significantly increased with 3 mmol/L VPA treatment for 2 d (2.498 +/- 0.240). Valproic Acid 64-67 cyclin dependent kinase inhibitor 1A Homo sapiens 4-7 19176032-9 2008 The p21(WAF1/CIP) protein significantly increased with 3 mmol/L VPA treatment for 2 d (2.498 +/- 0.240). Valproic Acid 64-67 cyclin dependent kinase inhibitor 1A Homo sapiens 8-12 17534580-0 2007 Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines. Valproic Acid 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 22-25 17534580-8 2007 Further, VPA and not etoposide, promoted acetylation of histone H4 and induced the expression of the cyclin-dependent kinase inhibitor (CDKI), p21/WAF1. Valproic Acid 9-12 cyclin dependent kinase inhibitor 1A Homo sapiens 143-146 17534580-8 2007 Further, VPA and not etoposide, promoted acetylation of histone H4 and induced the expression of the cyclin-dependent kinase inhibitor (CDKI), p21/WAF1. Valproic Acid 9-12 cyclin dependent kinase inhibitor 1A Homo sapiens 147-151 17218782-10 2007 IC(50) dose (2.99 mM) of VPA was able to induce G(1) arrest (up to 75%) in association with upregulation of p16, p21 and cyclin-D1 related to Rb ipo-phosphorilation. Valproic Acid 25-28 cyclin dependent kinase inhibitor 1A Homo sapiens 113-116 16990052-7 2006 We hypothesized that VPA induction of the cell-cycle-regulating protein p21(WAF1/CIP1) may be partly responsible for this activity. Valproic Acid 21-24 cyclin dependent kinase inhibitor 1A Homo sapiens 72-75 16990052-7 2006 We hypothesized that VPA induction of the cell-cycle-regulating protein p21(WAF1/CIP1) may be partly responsible for this activity. Valproic Acid 21-24 cyclin dependent kinase inhibitor 1A Homo sapiens 76-80 16990052-7 2006 We hypothesized that VPA induction of the cell-cycle-regulating protein p21(WAF1/CIP1) may be partly responsible for this activity. Valproic Acid 21-24 cyclin dependent kinase inhibitor 1A Homo sapiens 81-85