PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30405207-7 2018 VPA lowered CCI-induced inflammatory proteins (pNFkappaB, iNOS and COX-2), pro-apoptotic proteins (pAKT/AKT and pGSK-3beta/GSK-3beta), proinflammatory cytokines (TNF-alpha and IL-1beta) and nuclear pNFkappaB activation in the SN, DRG and SC in CCI rats. Valproic Acid 0-3 glycogen synthase kinase 3 beta Rattus norvegicus 112-132 26030405-0 2015 Valproate Inhibits Methamphetamine Induced Hyperactivity via Glycogen Synthase Kinase 3beta Signaling in the Nucleus Accumbens Core. Valproic Acid 0-9 glycogen synthase kinase 3 beta Rattus norvegicus 61-91 25777823-8 2015 The downstream prosurvival protein phospho-GSK-3beta was significantly higher in the sham, hypo, and combined treatment groups compared with that in normothermia groups with or without VPA (P < 0.05). Valproic Acid 185-188 glycogen synthase kinase 3 beta Rattus norvegicus 43-52 27789311-0 2017 Lithium and valproate act on the GSK-3beta signaling pathway to reverse manic-like behavior in an animal model of mania induced by ouabain. Valproic Acid 12-21 glycogen synthase kinase 3 beta Rattus norvegicus 33-42 26030405-2 2015 Although glycogen synthase kinase 3beta (GSK3beta) signaling in the nucleus accumbens (NAc) plays a key role in mediating dopamine (DA)-dependent behaviors, there is less direct evidence that how VPA acts on the GSK3beta signaling in the functionally distinct sub-regions of the NAc, the NAc core (NAcC) and the NAc shell (NAcSh), during psycho-stimulant-induced hyperactivity. Valproic Acid 196-199 glycogen synthase kinase 3 beta Rattus norvegicus 9-39 26030405-8 2015 Our results suggested that GSK3beta activity in NAcC contributes to the inhibitory effects of VPA on MA-induced hyperactivity. Valproic Acid 94-97 glycogen synthase kinase 3 beta Rattus norvegicus 27-35 25547373-2 2015 Lithium chloride (LiCl) and valproate (VPA), two well-known mood stabilizers, have been reported to act through GSK-3beta and HDAC inhibition, respectively. Valproic Acid 28-37 glycogen synthase kinase 3 beta Rattus norvegicus 112-121 25547373-2 2015 Lithium chloride (LiCl) and valproate (VPA), two well-known mood stabilizers, have been reported to act through GSK-3beta and HDAC inhibition, respectively. Valproic Acid 39-42 glycogen synthase kinase 3 beta Rattus norvegicus 112-121 23474375-0 2013 Chronic valproic acid administration impairs contextual memory and dysregulates hippocampal GSK-3beta in rats. Valproic Acid 8-21 glycogen synthase kinase 3 beta Rattus norvegicus 92-101 24884462-0 2014 Valproate pretreatment protects pancreatic beta-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3beta. Valproic Acid 0-9 glycogen synthase kinase 3 beta Rattus norvegicus 115-145 24884462-3 2014 Thus, we hypothesized that valproate may protect INS-1 beta-cells from palmitate-induced apoptosis via inhibiting GSK-3beta. Valproic Acid 27-36 glycogen synthase kinase 3 beta Rattus norvegicus 114-123 24884462-6 2014 However, valproate not only reduced the mRNA and protein expression of CHOP but also inhibited GSK-3beta and caspase-3 activity induced by palmitate, whereas, the mRNA expression of ATF4 was not affected. Valproic Acid 9-18 glycogen synthase kinase 3 beta Rattus norvegicus 95-104 24884462-9 2014 CONCLUSIONS: Valproate may protect beta-cells from palmitate-induced apoptosis and ER stress via GSK-3beta inhibition, independent of ATF4/CHOP pathway. Valproic Acid 13-22 glycogen synthase kinase 3 beta Rattus norvegicus 97-106 24211784-0 2014 Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3beta and beta-catenin pathway. Valproic Acid 0-9 glycogen synthase kinase 3 beta Rattus norvegicus 141-150 24211784-11 2014 Moreover, VPA increased the phosphorylation of Ser(9), which is known as the inhibitory phosphorylation site of GSK-3beta. Valproic Acid 10-13 glycogen synthase kinase 3 beta Rattus norvegicus 112-121 18983912-5 2009 Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling. Valproic Acid 12-21 glycogen synthase kinase 3 beta Rattus norvegicus 106-114 22841957-0 2012 Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3beta/beta-catenin pathway. Valproic Acid 21-34 glycogen synthase kinase 3 beta Rattus norvegicus 145-154 19068119-1 2008 BACKGROUND: Valproic acid (VPA), a commonly used mood stabilizer that promotes neuronal differentiation, regulates multiple signaling pathways involving extracellular signal-regulated kinase (ERK) and glycogen synthase kinase3beta (GSK3beta). Valproic Acid 12-25 glycogen synthase kinase 3 beta Rattus norvegicus 201-230 19068119-1 2008 BACKGROUND: Valproic acid (VPA), a commonly used mood stabilizer that promotes neuronal differentiation, regulates multiple signaling pathways involving extracellular signal-regulated kinase (ERK) and glycogen synthase kinase3beta (GSK3beta). Valproic Acid 12-25 glycogen synthase kinase 3 beta Rattus norvegicus 232-240 19068119-1 2008 BACKGROUND: Valproic acid (VPA), a commonly used mood stabilizer that promotes neuronal differentiation, regulates multiple signaling pathways involving extracellular signal-regulated kinase (ERK) and glycogen synthase kinase3beta (GSK3beta). Valproic Acid 27-30 glycogen synthase kinase 3 beta Rattus norvegicus 201-230 19068119-1 2008 BACKGROUND: Valproic acid (VPA), a commonly used mood stabilizer that promotes neuronal differentiation, regulates multiple signaling pathways involving extracellular signal-regulated kinase (ERK) and glycogen synthase kinase3beta (GSK3beta). Valproic Acid 27-30 glycogen synthase kinase 3 beta Rattus norvegicus 232-240 16191209-2 2006 GSK-3beta has recently been suggested to be an intracellular target of the mood stabilizers lithium and valproate and of the typical and atypical antipsychotic agents haloperidol and clozapine. Valproic Acid 104-113 glycogen synthase kinase 3 beta Rattus norvegicus 0-9