PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32723256-6	2021	Additionally, HO-AAVPA reduced the number of vessels in chorioallantoid membranes (CAMs) by approximately 67.74% and IL-6 levels in both cell lines suggesting that the biochemical mechanism on cancer cell of HO-AAVPA is different compared to VPA.	Valproic Acid	19-22	interleukin 6	Homo sapiens	117-121	
32782515-0	2020	Sodium valproate combined with levetiracetam in pediatric epilepsy and its influence on NSE, IL-6, hs-CRP and electroencephalogram improvement.	Valproic Acid	0-16	interleukin 6	Homo sapiens	93-97	
32782515-1	2020	Efficacy of sodium valproate combined with levetiracetam (LEV) in pediatric epilepsy and its influence on neuron-specific enolase (NSE), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) as well as electroencephalogram (EEG) improvement were studied.	Valproic Acid	12-28	interleukin 6	Homo sapiens	137-150	
32782515-8	2020	In the treatment of pediatric epilepsy, sodium valproate combined with LEV produces better efficacy, fewer adverse reactions, significantly improves patients" QOL and notably lowers the content of NSE, IL-6 and hs-CRP with notable EEG improvement, so it is a safe and reliable treatment that is worth popularization.	Valproic Acid	40-56	interleukin 6	Homo sapiens	202-206	
24757498-2	2014	Recent in vitro and animal studies of valproic acid (VPA) report antioxidative and anti-inflammatory properties, and suppression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha.	Valproic Acid	38-51	interleukin 6	Homo sapiens	132-150	
31785814-5	2020	Interestingly, the combination treatment of VPA and anti-PD-L1 antibody activated IRF1/IRF8 transcriptional axis in MDSCs leading to blockade of their immunosuppressive function by downregulating the expression of IL-10, IL-6, and ARG1 while re-activating CD8+ T-cells for the production of TNFalpha to further enhance anti-tumor immunity.	Valproic Acid	44-47	interleukin 6	Homo sapiens	221-225	
27639185-5	2017	VPA and lithium both induce significant down-regulation of group I CD1 expression and secretion of IL-6 during differentiation of human monocyte-derived immature DC, while they differ in the induction of CD83 and CD86 expression, secretion of IL-8, IL-10, and TNF-alpha.	Valproic Acid	0-3	interleukin 6	Homo sapiens	99-103	
24742998-4	2014	METHODS AND RESULTS: We showed that VPA inhibited the production of IFN-alpha and the proinflammatory cytokines TNF-alpha and IL-6 by CpG-activated PDC.	Valproic Acid	36-39	interleukin 6	Homo sapiens	126-130	
24757498-2	2014	Recent in vitro and animal studies of valproic acid (VPA) report antioxidative and anti-inflammatory properties, and suppression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha.	Valproic Acid	53-56	interleukin 6	Homo sapiens	132-150	
21866484-8	2011	In vitro and in vivo experiments show that antiepileptic drugs could affect cytokine levels (e.g. valproate significantly inhibited production of TNF- alpha and IL-6 by human monocytic leukaemia cells).	Valproic Acid	98-107	interleukin 6	Homo sapiens	161-165	
34635175-11	2021	The production of inflammatory cytokines (TNF-alpha and IL-6) induced by TNF-alpha and SARS-CoV-2 infection is diminished in the presence of VPA.	Valproic Acid	141-144	interleukin 6	Homo sapiens	56-60	
16192836-0	2005	Effect of valproate on plasma levels of interleukin-6 in healthy male humans.	Valproic Acid	10-19	interleukin 6	Homo sapiens	40-53	
16192836-2	2005	The present study aimed to determine whether there is a treatment effect of valproate on plasma levels of the pro-inflammatory cytokine, interleukin (IL)-6, in healthy male humans.	Valproic Acid	76-85	interleukin 6	Homo sapiens	137-155	
16192836-3	2005	Plasma levels of IL-6 were measured in 10 healthy male humans before and after 7 days of treatment with 1000 mg per day of valproate (i.e. 500 mg in the morning and 500 mg in the evening).	Valproic Acid	123-132	interleukin 6	Homo sapiens	17-21	
16192836-9	2005	We found a significant increase in plasma levels of IL-6 after the 7 days of valproate treatment in healthy male subjects.	Valproic Acid	77-86	interleukin 6	Homo sapiens	52-56	
16192836-10	2005	Furthermore, there was a significant positive correlation between the changes in plasma IL-6 and blood levels of valproic acid.	Valproic Acid	113-126	interleukin 6	Homo sapiens	88-92	
16192836-11	2005	The findings of this study are consistent with previous studies on subjects with epilepsy, suggesting a modulating effect of valproate on the pro-inflammatory cytokine IL-6 in humans.	Valproic Acid	125-134	interleukin 6	Homo sapiens	168-172	
19205364-13	2008	In vitro valproate inhibits TNFa and IL-6 production, whereas in epileptic patients this drug enhances IL-1, IL-6 and IL-5 concentration.	Valproic Acid	9-18	interleukin 6	Homo sapiens	37-41	
12807426-5	2003	We found that VPA dose-dependently inhibited SP-induced IL-6 synthesis which was seen with pre-incubation periods of 30 min, 3, 7 and 14 days, whereas carbamazepine and lithium showed no inhibitory effect.	Valproic Acid	14-17	interleukin 6	Homo sapiens	56-60	
10700573-0	2000	Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB.	Valproic Acid	0-16	interleukin 6	Homo sapiens	54-58	
10700573-8	2000	VPA significantly inhibited LPS-induced production of TNF-alpha and IL-6 by THP-1 cells, whereas other AEDs did not.	Valproic Acid	0-3	interleukin 6	Homo sapiens	68-72	
10700573-9	2000	The findings are consistent with the idea that VPA suppresses TNF-alpha and IL-6 production via inhibition of NF-kappaB activation.	Valproic Acid	47-50	interleukin 6	Homo sapiens	76-80	
34630611-8	2021	After treatment, the levels of NSE, MBP, TNF-alpha, and IL-6 in the two groups decreased, and the levels of BDNF increased, and the LEV group changed significantly compared with the VPA group (P < 0.05).	Valproic Acid	182-185	interleukin 6	Homo sapiens	56-60	
34122007-9	2021	Meanwhile, VPA reduced dMCAo-induced elevation of IL-6 at 24 h post-stroke and significantly decreased the number of CD11b-positive microglia within peri-infarct cortex at 7 days.	Valproic Acid	11-14	interleukin 6	Homo sapiens	50-54