PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31265853-0 2019 Valproic acid attenuates sepsis-induced myocardial dysfunction in rats by accelerating autophagy through the PTEN/AKT/mTOR pathway. Valproic Acid 0-13 AKT serine/threonine kinase 1 Rattus norvegicus 114-117 30405207-7 2018 VPA lowered CCI-induced inflammatory proteins (pNFkappaB, iNOS and COX-2), pro-apoptotic proteins (pAKT/AKT and pGSK-3beta/GSK-3beta), proinflammatory cytokines (TNF-alpha and IL-1beta) and nuclear pNFkappaB activation in the SN, DRG and SC in CCI rats. Valproic Acid 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 100-103 34175324-7 2021 It suggests that prenatal VPA exposure may affect the spatiotemporal regularity of neuronal apoptosis and synaptic development/regression via interfering with the spatiotemporal process of PGRN expression and downstream AKT/GSK-3beta pathway activation. Valproic Acid 26-29 AKT serine/threonine kinase 1 Rattus norvegicus 220-223 27590472-0 2016 Corrigendum to "Neuroprotective and anti-apoptotic effects of valproic acid on adult rat cerebral cortex through ERK and Akt signaling pathway at acute phase of traumatic brain injury" [Brain Res.1555 (2014, Mar. Valproic Acid 62-75 AKT serine/threonine kinase 1 Rattus norvegicus 121-124 26639559-3 2016 We found that DHA supplementation (75, 150 or 300 mg/kg/day, 21 days) rescued the VPA (600 mg/kg) induced DHA reduction in plasma and hippocampus in a dose-dependent manner, increased the levels of hippocampal p-CaMKII and p-CREB without affecting total protein level, and altered BDNF-AKT-Bcl-2 signaling pathway, as well as inhibited the activity of caspase-3. Valproic Acid 82-85 AKT serine/threonine kinase 1 Rattus norvegicus 286-289 24508577-0 2014 Neuroprotective and anti-apoptotic effects of valproic acid on adult rat cerebral cortex through ERK and Akt signaling pathway at acute phase of traumatic brain injury. Valproic Acid 46-59 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 24508577-7 2014 Moreover, treatment with either PD98059, an ERK inhibitor and/or LY294002, an Akt inhibitor, attenuated the neuroprotection of VPA against TBI to varying degrees. Valproic Acid 127-130 AKT serine/threonine kinase 1 Rattus norvegicus 78-81 24508577-8 2014 Taken together, these results demonstrated that treatment with VPA after TBI could be neuroprotective via activation of ERK and Akt signaling pathways. Valproic Acid 63-66 AKT serine/threonine kinase 1 Rattus norvegicus 128-131 23838963-5 2013 The mood-stabilizing agents lithium chloride and valproic acid, which have attenuating effects on the Akt/GSK3 pathway, also partially generalized to the discriminative stimulus effects of U-50,488H. Valproic Acid 49-62 AKT serine/threonine kinase 1 Rattus norvegicus 102-105 21036453-10 2011 Phospho-Akt protein increased in the VPA group with a reciprocal decrease in the pro-apoptotic BAD protein in both groups which was statistically significant in the VPA group after 1h (p=0.007) and 24h (p=0.006) of treatment and in the SAHA group after 24h of treatment (p=0.028). Valproic Acid 37-40 AKT serine/threonine kinase 1 Rattus norvegicus 8-11 21036453-10 2011 Phospho-Akt protein increased in the VPA group with a reciprocal decrease in the pro-apoptotic BAD protein in both groups which was statistically significant in the VPA group after 1h (p=0.007) and 24h (p=0.006) of treatment and in the SAHA group after 24h of treatment (p=0.028). Valproic Acid 165-168 AKT serine/threonine kinase 1 Rattus norvegicus 8-11 30300655-0 2018 Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway. Valproic Acid 10-23 AKT serine/threonine kinase 1 Rattus norvegicus 130-133 27244466-0 2016 Neuroprotective Effects of Valproic Acid on Blood-Brain Barrier Disruption and Apoptosis-Related Early Brain Injury in Rats Subjected to Subarachnoid Hemorrhage Are Modulated by Heat Shock Protein 70/Matrix Metalloproteinases and Heat Shock Protein 70/AKT Pathways. Valproic Acid 27-40 AKT serine/threonine kinase 1 Rattus norvegicus 252-255 26886004-10 2016 Western blot analysis showed a concomitant increase in BCL-2 protein expression and Akt phosphorylation following VPA treatment. Valproic Acid 114-117 AKT serine/threonine kinase 1 Rattus norvegicus 84-87 26886004-12 2016 CONCLUSION: These findings suggest that VPA protects myocardial cells from hemorrhagic and hypoxic stress through the Akt/BCL-2 survival pathway, indicating a potential use of HDACIs for acute severe hemorrhage treatment. Valproic Acid 40-43 AKT serine/threonine kinase 1 Rattus norvegicus 118-121 25627160-7 2015 Similarly, phosphorylated and total Akt, mTOR and 4E-BP1 and phosphorylated S6 protein were decreased in valproic acid- versus saline-exposed rats. Valproic Acid 105-118 AKT serine/threonine kinase 1 Rattus norvegicus 36-39 22867974-14 2012 VPA and SB suppressed reductions in a- and b-wave amplitudes of the ERG and attenuated the activation of caspase-3 in the RGCs, which was accompanied by upregulation in Akt and Erk phosphorylation in the retina. Valproic Acid 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 169-172 34205883-0 2021 Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats. Valproic Acid 0-13 AKT serine/threonine kinase 1 Rattus norvegicus 54-57 34205883-9 2021 Treatment with VPA upregulated histone H3 acetylation and conferred anti-vasospastic and neuro-protective effects by enhancing Akt and/or ERK phosphorylation. Valproic Acid 15-18 AKT serine/threonine kinase 1 Rattus norvegicus 127-130 35401102-11 2022 Pathway enrichment analysis of DEGs between the control and VPA-induced autism model group showed that the PI3K/AKT and Wnt pathways were significantly dysregulated in the VPA-induced autism model group. Valproic Acid 60-63 AKT serine/threonine kinase 1 Rattus norvegicus 112-115 35401102-11 2022 Pathway enrichment analysis of DEGs between the control and VPA-induced autism model group showed that the PI3K/AKT and Wnt pathways were significantly dysregulated in the VPA-induced autism model group. Valproic Acid 172-175 AKT serine/threonine kinase 1 Rattus norvegicus 112-115