PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15075379-0	2004	Abolition of valproate-derived choleresis in the Mrp2 transporter-deficient rat.	Valproic Acid	13-22	ATP binding cassette subfamily C member 2	Rattus norvegicus	49-53	
31368504-0	2019	Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization.	Valproic Acid	20-29	ATP binding cassette subfamily C member 2	Rattus norvegicus	55-59	
31368504-9	2019	Mechanistic studies suggested that valproate inhibited canalicular trafficking of Mrp2.	Valproic Acid	35-44	ATP binding cassette subfamily C member 2	Rattus norvegicus	82-86	
31368504-10	2019	This effect of valproate on Mrp2 appeared to be selective in that valproate had less impact on canalicular levels of the bile salt export pump (Bsep) and no detectable effect on P-glycoprotein (P-gp) canalicular levels.	Valproic Acid	15-24	ATP binding cassette subfamily C member 2	Rattus norvegicus	28-32	
31368504-10	2019	This effect of valproate on Mrp2 appeared to be selective in that valproate had less impact on canalicular levels of the bile salt export pump (Bsep) and no detectable effect on P-glycoprotein (P-gp) canalicular levels.	Valproic Acid	66-75	ATP binding cassette subfamily C member 2	Rattus norvegicus	28-32	
31368504-12	2019	These findings reveal that two novel mechanisms may contribute to valproate hepatotoxicity: impaired canalicular trafficking of Mrp2 and disruption of ZO2-associated hepatocyte polarization.	Valproic Acid	66-75	ATP binding cassette subfamily C member 2	Rattus norvegicus	128-132