PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3131067-1	1988	Previous CPR studies from our laboratory have shown that a standard iv dose of lidocaine (2 mg/kg) has a rapid antifibrillatory effect, while a standard dose of bretylium (5 mg/kg) produces a delayed but more pronounced effect.	bretylium	161-170	cytochrome p450 oxidoreductase	Canis lupus familiaris	9-12	
3131067-5	1988	The combination of lidocaine and bretylium (11 dogs) caused a significant increase in VFT compared to the control phase after each of the 3-min CPR periods and maintained this effect for greater than 2 h. Bretylium 10 mg/kg (eight dogs) significantly elevated the VFT only after the third 3-min CPR period.	bretylium	33-42	cytochrome p450 oxidoreductase	Canis lupus familiaris	144-147	
3131067-6	1988	We conclude that the combination of standard doses of lidocaine and bretylium produces a rapid and prolonged antifibrillatory effect and may be the optimal regimen in the CPR setting.	bretylium	68-77	cytochrome p450 oxidoreductase	Canis lupus familiaris	171-174