PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30088792-0	2019	In vitro and in silico evaluation of fucosterol from Sargassum horridum as potential human acetylcholinesterase inhibitor.	fucosterol	37-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111	
30088792-2	2019	In this study, the activity in vitro of the fucosterol from Sargassum horridum as potential human acetylcholinesterase inhibitor was evaluated.	fucosterol	44-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-118	
30088792-3	2019	The structural identification was obtained by nuclear magnetic resonance (NMR) spectroscopy and based on experimental data, we combined docking and molecular dynamics simulations coupled to the molecular-mechanics-generalized-born-surface-area approach to evaluating the structural and energetic basis for the molecular recognition of fucosterol and neostigmine at the binding site of acetylcholinesterase (AChE).	fucosterol	335-345	acetylcholinesterase (Cartwright blood group)	Homo sapiens	385-405	
30088792-3	2019	The structural identification was obtained by nuclear magnetic resonance (NMR) spectroscopy and based on experimental data, we combined docking and molecular dynamics simulations coupled to the molecular-mechanics-generalized-born-surface-area approach to evaluating the structural and energetic basis for the molecular recognition of fucosterol and neostigmine at the binding site of acetylcholinesterase (AChE).	fucosterol	335-345	acetylcholinesterase (Cartwright blood group)	Homo sapiens	407-411	
30088792-7	2019	Structural analysis revealed that neostigmine reaches the AChE binding site reported elsewhere, whereas fucosterol can act as a no-competitive and competitive acetylcholinesterase inhibitor, in agree with kinetic enzymatic experiments.	fucosterol	104-114	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-179	
30088792-8	2019	Binding free energy calculations revealed that fucosterol reaches the acetylcholinesterase binding site with higher affinity than neostigmine, which is according to experimental results.	fucosterol	47-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-90	
30088792-10	2019	Results corroborate the ability of theoretical methods to provide crucial information at the atomic level about energetic and structural differences in the binding interaction and affinity from fucosterol with AChE.	fucosterol	194-204	acetylcholinesterase (Cartwright blood group)	Homo sapiens	210-214