PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15618670-1	2002	The participation of cytochrome P-450 (CYP) isoforms in the metabolism of selegiline was investigated.	Selegiline	74-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-37	
15618670-1	2002	The participation of cytochrome P-450 (CYP) isoforms in the metabolism of selegiline was investigated.	Selegiline	74-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-42	
15618670-2	2002	Experiments using recombinant CYP isoforms expressed in human lymphoblastoid cells showed CYP2B6 to be the major CYP isoform involved with the metabolism of selegiline.	Selegiline	157-167	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	30-33	
15618670-2	2002	Experiments using recombinant CYP isoforms expressed in human lymphoblastoid cells showed CYP2B6 to be the major CYP isoform involved with the metabolism of selegiline.	Selegiline	157-167	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	90-93	
10862503-2	2000	In the current work we have studied the cytochrome P450 (CYP)-catalyzed oxidative metabolism of selegiline to desmethylselegiline and 1-methamphetamine and the effects of selegiline, desmethylselegiline and 1-methamphetamine on hepatic CYP enzymes in human liver microsomes in vitro.	Selegiline	96-106	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55	
10862503-2	2000	In the current work we have studied the cytochrome P450 (CYP)-catalyzed oxidative metabolism of selegiline to desmethylselegiline and 1-methamphetamine and the effects of selegiline, desmethylselegiline and 1-methamphetamine on hepatic CYP enzymes in human liver microsomes in vitro.	Selegiline	96-106	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-60	
10862503-2	2000	In the current work we have studied the cytochrome P450 (CYP)-catalyzed oxidative metabolism of selegiline to desmethylselegiline and 1-methamphetamine and the effects of selegiline, desmethylselegiline and 1-methamphetamine on hepatic CYP enzymes in human liver microsomes in vitro.	Selegiline	96-106	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	236-239	
10862503-2	2000	In the current work we have studied the cytochrome P450 (CYP)-catalyzed oxidative metabolism of selegiline to desmethylselegiline and 1-methamphetamine and the effects of selegiline, desmethylselegiline and 1-methamphetamine on hepatic CYP enzymes in human liver microsomes in vitro.	Selegiline	119-129	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55	
10862503-2	2000	In the current work we have studied the cytochrome P450 (CYP)-catalyzed oxidative metabolism of selegiline to desmethylselegiline and 1-methamphetamine and the effects of selegiline, desmethylselegiline and 1-methamphetamine on hepatic CYP enzymes in human liver microsomes in vitro.	Selegiline	119-129	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-60	
10862503-8	2000	In studies with CYP-specific model activities, both selegiline and desmethylselegiline inhibited the CYP2C19-mediated S-mephenytoin 4"-hydroxylation with average IC50 values of 21 microM and 26 microM, respectively.	Selegiline	52-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	16-19	
10862503-11	2000	Inhibitory potencies of selegiline, desmethylselegiline and 1-methamphetamine towards other CYP-model activities were much lower.	Selegiline	24-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-95