PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28110804-7	2017	Removal of uracil is followed by the generation of an abasic site and subsequent cleavage by AP endonuclease 1 (APE1).	Uracil	11-17	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	93-110	
10874010-10	2000	These results indicate that the cellular level of APE1 may differentially affect repair efficiency for DNA strand breaks but not for uracil and AP sites in DNA.	Uracil	133-139	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	50-54	
28110804-7	2017	Removal of uracil is followed by the generation of an abasic site and subsequent cleavage by AP endonuclease 1 (APE1).	Uracil	11-17	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	112-116	
32864084-4	2020	We design a bifunctional double-stranded DNA (dsDNA) substrate with a hypoxanthine base (I) in one strand for hAAG recognition and an uracil (U) base in the other strand for UDG recognition, whose cleavage by APE1 generates two corresponding primers.	Uracil	134-140	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	209-213	
33333017-3	2021	Here we report that loss of ALC1 confers sensitivity to PARP inhibitors, methyl-methanesulfonate, and uracil misincorporation, which reflects the need to remodel nucleosomes following base excision by DNA glycosylases but prior to handover to APEX1.	Uracil	102-108	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	243-248	
30459925-8	2018	The DNA repair enzyme, each Fpg, hOGG1 could cleave an 8-oxoG-containing DNA substrate, the mixture of UDG and APE1 could cleave a uracil-containing DNA substrate.	Uracil	131-137	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	111-115	
22492624-10	2012	These non-sequence-specific DNA-binding surfaces may aid local uracil search, contribute to binding the abasic DNA product and help present the DNA product to APE-1, the next enzyme on the DNA-repair pathway.	Uracil	63-69	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	159-164	
23543741-14	2013	Near the dyad, uracil DNA glycosylase/APE1 removes an outwardly oriented uracil efficiently; however, polymerase beta activity is significantly inhibited at this site.	Uracil	15-21	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	38-42	
21357694-4	2011	We show that cytosines that flank the cisplatin ICLs undergo preferential oxidative deamination in vitro, and AP endonuclease 1 (APE1) can cleave the resulting ICL DNA substrate following removal of the flanking uracil.	Uracil	212-218	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	110-127	
21357694-4	2011	We show that cytosines that flank the cisplatin ICLs undergo preferential oxidative deamination in vitro, and AP endonuclease 1 (APE1) can cleave the resulting ICL DNA substrate following removal of the flanking uracil.	Uracil	212-218	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	129-133	
20628060-6	2010	For uracil sites within the GRE, there was a reduced rate of uracil-DNA glycosylase/Ape1 activity following GR-DBD binding.	Uracil	4-10	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	84-88	
17272283-6	2007	Furthermore, the in vitro cleavage experiment using uracil-containing single-stranded DNA as a template has demonstrated that the uracil-excising catalytic activity of virion-associated UNG2 can remove dU from the uracil-containing viral DNA and leave an abasic site, which could be further cleaved by virion-associated APE.	Uracil	52-58	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	320-323	
17272283-6	2007	Furthermore, the in vitro cleavage experiment using uracil-containing single-stranded DNA as a template has demonstrated that the uracil-excising catalytic activity of virion-associated UNG2 can remove dU from the uracil-containing viral DNA and leave an abasic site, which could be further cleaved by virion-associated APE.	Uracil	130-136	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	320-323	
17272283-6	2007	Furthermore, the in vitro cleavage experiment using uracil-containing single-stranded DNA as a template has demonstrated that the uracil-excising catalytic activity of virion-associated UNG2 can remove dU from the uracil-containing viral DNA and leave an abasic site, which could be further cleaved by virion-associated APE.	Uracil	130-136	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	320-323	
15590328-2	2005	We found that UDG and APE carry out their catalytic activities with reduced efficiency on nucleosome substrates, showing a distinction between uracil facing "out" or "in" from the histone surface, while DNA polymerase beta (pol beta) is completely inhibited by nucleosome formation.	Uracil	143-149	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	22-25