PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19123462-6	2009	The MTHFR 677T mutation was associated with a nonsignificant trend toward decreased and increased uracil misincorporation in HCT116 and MDA-MB-435 cells, respectively.	Uracil	98-104	methylenetetrahydrofolate reductase	Homo sapiens	4-9	
19123462-0	2009	The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.	Uracil	116-122	methylenetetrahydrofolate reductase	Homo sapiens	4-39	
20039875-2	2010	PATIENTS AND METHODS: MTHFR C677T and A1298C polymorphisms have been reported to cause decreased enzyme activity, which reduces the quantity of methyl groups available for DNA methylation and leads to mis-incorporation of uracil into DNA, resulting in single-strand DNA breaks.	Uracil	222-228	methylenetetrahydrofolate reductase	Homo sapiens	22-27	
18842806-10	2008	The MTHFR 677TT genotype was associated with a approximately 34% lower DNA uracil content (P = 0.045), whereas the G allele of the GGH -124T>G SNP was associated with a stepwise increase in DNA uracil content (P = 0.022).	Uracil	75-81	methylenetetrahydrofolate reductase	Homo sapiens	4-9	
18842806-11	2008	CONCLUSION: Because the accumulation of uracil in DNA induces chromosome breaks, mutagenic lesions, we suggest that, as for MTHFR C677T, the GGH -124 T>G SNP may modulate the risk of carcinogenesis and therefore warrants further attention.	Uracil	40-46	methylenetetrahydrofolate reductase	Homo sapiens	124-129	
17709451-2	2007	This study investigated the effect of MTHFR C677T genotype and daily supplementation with 5 mg folic acid and 1.25 mg vitamin B-12 on uracil misincorporation into DNA and promoter methylation.	Uracil	134-140	methylenetetrahydrofolate reductase	Homo sapiens	38-43	
15342443-0	2004	Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo.	Uracil	190-196	methylenetetrahydrofolate reductase	Homo sapiens	65-100	
11588136-4	2001	This hypothesis is based on the assumption that reduced MTHFR activity in TT lymphocytes causes a diversion of 5,10-methylene tetrahydrofolate toward thymidine synthesis, which minimizes uracil-induced double-stranded DNA breakage.	Uracil	187-193	methylenetetrahydrofolate reductase	Homo sapiens	56-61	
34502300-0	2021	MTHFR Knockdown Assists Cell Defense against Folate Depletion Induced Chromosome Segregation and Uracil Misincorporation in DNA.	Uracil	97-103	methylenetetrahydrofolate reductase	Homo sapiens	0-5	
16043029-0	2005	Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms.	Uracil	0-6	methylenetetrahydrofolate reductase	Homo sapiens	140-175