PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23197286-4	2013	Of interest is that hepatic DPD activity levels and the dihydrouracil-uracil ratio (UH2/Ura ratio) in plasma, which may act as a potential biomarker to evaluate hepatic DPD activity levels, were significantly increased in CRC rats.	Uracil	63-69	dihydropyrimidine dehydrogenase	Rattus norvegicus	169-172	
30592773-0	2019	Association between the pharmacokinetics of capecitabine and the plasma dihydrouracil to uracil ratio in rat: A surrogate biomarker for dihydropyrimidine dehydrogenase activity.	Uracil	79-85	dihydropyrimidine dehydrogenase	Rattus norvegicus	136-167	
23836081-1	2013	The relationship between the plasma ratio of dihydrouracil/uracil (UH2/Ura) and hepatic dihydropyrimidine dehydrogenase (DPD) activity after repeated 5-fluorouracil (5-FU) treatment in rats with colorectal cancer (CRC) was investigated.	Uracil	52-58	dihydropyrimidine dehydrogenase	Rattus norvegicus	121-124	
23836081-1	2013	The relationship between the plasma ratio of dihydrouracil/uracil (UH2/Ura) and hepatic dihydropyrimidine dehydrogenase (DPD) activity after repeated 5-fluorouracil (5-FU) treatment in rats with colorectal cancer (CRC) was investigated.	Uracil	71-74	dihydropyrimidine dehydrogenase	Rattus norvegicus	121-124	
23836081-4	2013	Moreover, a significant correlation was found between the plasma ratio of UH2/Ura and hepatic DPD activity in CRC rats untreated and treated with single or repeated 5-FU administration (r(2)  = 0.865, p < 0.01).	Uracil	78-81	dihydropyrimidine dehydrogenase	Rattus norvegicus	94-97	
23836081-5	2013	The ratio of UH2/Ura in plasma could be a predictive biomarker of the suppression of hepatic DPD levels during repeated 5-FU-based treatment.	Uracil	17-20	dihydropyrimidine dehydrogenase	Rattus norvegicus	93-96	
23836081-6	2013	Furthermore, by plotting the observed pharmacokinetic parameters of 5-FU against hepatic DPD activity levels predicted by the ratio of UH2/Ura in plasma, AUC0-  , CLtot and half-life (t1/2 ) were closely linked to predicted hepatic DPD activity levels.	Uracil	139-142	dihydropyrimidine dehydrogenase	Rattus norvegicus	89-92	
23836081-7	2013	These observations suggest that the factor that significantly influences the AUC0-  , CLtot and t1/2 of 5-FU after single or repeated administration of 5-FU is the hepatic DPD activity and it could be assessed by the ratio of UH2/Ura in plasma.	Uracil	230-233	dihydropyrimidine dehydrogenase	Rattus norvegicus	172-175	
30592773-2	2019	The plasma ratio of dihydrouracil (UH2 ) to uracil (Ura) is expected to gain relevance as an indirect-response biomarker to estimate the activity of dihydropyrimidine dehydrogenase (DPD).	Uracil	27-33	dihydropyrimidine dehydrogenase	Rattus norvegicus	149-180	
30592773-2	2019	The plasma ratio of dihydrouracil (UH2 ) to uracil (Ura) is expected to gain relevance as an indirect-response biomarker to estimate the activity of dihydropyrimidine dehydrogenase (DPD).	Uracil	27-33	dihydropyrimidine dehydrogenase	Rattus norvegicus	182-185	
30592773-2	2019	The plasma ratio of dihydrouracil (UH2 ) to uracil (Ura) is expected to gain relevance as an indirect-response biomarker to estimate the activity of dihydropyrimidine dehydrogenase (DPD).	Uracil	52-55	dihydropyrimidine dehydrogenase	Rattus norvegicus	149-180	
30592773-2	2019	The plasma ratio of dihydrouracil (UH2 ) to uracil (Ura) is expected to gain relevance as an indirect-response biomarker to estimate the activity of dihydropyrimidine dehydrogenase (DPD).	Uracil	52-55	dihydropyrimidine dehydrogenase	Rattus norvegicus	182-185	
23197286-4	2013	Of interest is that hepatic DPD activity levels and the dihydrouracil-uracil ratio (UH2/Ura ratio) in plasma, which may act as a potential biomarker to evaluate hepatic DPD activity levels, were significantly increased in CRC rats.	Uracil	88-91	dihydropyrimidine dehydrogenase	Rattus norvegicus	169-172	
4053028-0	1985	Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase.	Uracil	63-69	dihydropyrimidine dehydrogenase	Rattus norvegicus	104-135	
23575271-1	2013	We investigated the correlation between plasma ratio of dihydrouracil/uracil (UH2/Ura), a possible surrogate biomarker of hepatic dihydropyrimidine dehydrogenase (DPD) activity, and 5-fluorouracil (5-FU) treatment efficacy in rats with colorectal cancer (CRC).	Uracil	63-69	dihydropyrimidine dehydrogenase	Rattus norvegicus	163-166	
4053028-1	1985	The kinetic properties and control mechanisms of 5-fluorouracil (5-FU), uracil, and thymine degradation by rat liver dihydropyrimidine dehydrogenase were studied in vitro.	Uracil	57-63	dihydropyrimidine dehydrogenase	Rattus norvegicus	117-148	
4053028-4	1985	The specific activities of dihydropyrimidine dehydrogenase (nmol/min/mg of protein) for 5-FU, uracil, and thymine were 0.82, 0.68, and 0.56, respectively.	Uracil	94-100	dihydropyrimidine dehydrogenase	Rattus norvegicus	27-58