PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8472808-0	1993	Misincorporation of uracil into the DNA of folate- and B12-deficient HL60 cells.	Uracil	20-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	55-58	
8472808-5	1993	The data demonstrate that misincorporation of uracil into DNA occurs in a myeloid cell line cultured in growth medium deficient in folate, B12 or both folate and B12.	Uracil	46-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	139-142	
8472808-5	1993	The data demonstrate that misincorporation of uracil into DNA occurs in a myeloid cell line cultured in growth medium deficient in folate, B12 or both folate and B12.	Uracil	46-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	162-165	
16197314-2	2005	Even though depletion of B12, a common B-vitamin deficiency in the elderly, has not often been invoked as a causative factor in carcinogenesis, a recent animal study demonstrated that a B12-deficient diet, which was of insufficient severity to cause anemia or illness, disturbed normal homeostasis of one-carbon metabolism in the colonic mucosa and resulted in diminished genomic DNA methylation and increased uracil misincorporation in DNA, both of which are purported mechanisms for one-carbon metabolism-related colonic carcinogenesis.	Uracil	410-416	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	186-189	
990190-1	1976	The serum "uracil+uridine" level, expressed as uracil, has been measured in 21 cases of vitamin B12 deficiency, in which the serum folate was normal, and compared with the level in 97 normal subjects.	Uracil	11-17	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	96-99	
990190-9	1976	They do show, however, that some aspect of uracil metabolism other than methylation is affected in vitamin B12 deficiency in man.	Uracil	43-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	107-110	
990191-10	1976	The latter were readily explained by the known action of vitamin B12 on "de novo" methionine synthesis and it is suggested that the synthesis of uracil, like that of methionine, might be influenced by vitamin B12 in man.	Uracil	145-151	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	209-212	
33548097-7	2021	We observe that a B12 deficiency leads to increased uracil misincorporation, leading to impaired DNA synthesis and genomic instability.	Uracil	52-58	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	18-21	
23724740-1	2013	Mechanisms postulated to link folate and B12 metabolism with cancer, including genome-wide hypomethylation, gene-specific promoter hypermethylation, and DNA uracil misincorporation, have been observed in prostate tumor cells.	Uracil	157-163	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	41-44	
16043029-0	2005	Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms.	Uracil	0-6	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	117-120	
16043029-2	2005	Changes in the folate and vitamin B12 status in the body influence the extent of uracil misincorporation (UrMis) into DNA, which is one of the biomarkers of genomic stability and, thus, portends a risk of cancer.	Uracil	81-87	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37	
10668486-7	1999	Some evidence, and mechanistic considerations, suggest that vitamin B12 and B6 deficiencies also cause high uracil and chromosome breaks.	Uracil	108-114	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	68-71	
11295149-6	2001	Some evidence, and mechanistic considerations, suggest that Vitamin B12 (14% US elderly) and B6 (10% of US) deficiencies also cause high uracil and chromosome breaks.	Uracil	137-143	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	68-71