PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21427733-2 2011 In a previous study, some of us identified four common single nucleotide polymorphisms (SNPs) in uracil-processing genes (rs2029166 and rs7296239 in SMUG1, rs34259 in UNG and rs4775748 in DUT) that were associated with significantly altered levels of uracil in human DNA. Uracil 97-103 deoxyuridine triphosphatase Homo sapiens 188-191 21427733-2 2011 In a previous study, some of us identified four common single nucleotide polymorphisms (SNPs) in uracil-processing genes (rs2029166 and rs7296239 in SMUG1, rs34259 in UNG and rs4775748 in DUT) that were associated with significantly altered levels of uracil in human DNA. Uracil 251-257 deoxyuridine triphosphatase Homo sapiens 188-191 19403629-1 2009 BACKGROUND: Five genes--UNG, SMUG1, MBD4, TDG, and DUT--are involved in the repair or prevention of uracil misincorporation into DNA, an anomaly that can cause mutagenic events that lead to cancer. Uracil 100-106 deoxyuridine triphosphatase Homo sapiens 51-54 19403629-6 2009 RESULTS: Four SNPs in DUT, UNG, and SMUG1 showed a significant association with DNA uracil concentration. Uracil 84-90 deoxyuridine triphosphatase Homo sapiens 22-25 19403629-7 2009 The SNPs in SMUG1 (rs2029166 and rs7296239) and UNG (rs34259) were associated with increased uracil concentrations in the variant genotypes (P = 0.011, 0.022, and 0.045, respectively), whereas the DUT SNP (rs4775748) was associated with a decrease (P = 0.023). Uracil 93-99 deoxyuridine triphosphatase Homo sapiens 197-200 19403629-9 2009 CONCLUSION: Because elevated uracil misincorporation may induce mutagenic lesions, possibly leading to cancer, we propose that the 4 characterized SNPs in DUT, UNG, and SMUG1 may influence cancer risk and therefore deserve further investigation. Uracil 29-35 deoxyuridine triphosphatase Homo sapiens 155-158 6140747-1 1983 Crude extracts of human lymphocytic cells contain two enzymes which putatively exclude uracil from DNA: uracil-DNA glycosylase and deoxyuridine triphosphatase (dUTPase). Uracil 87-93 deoxyuridine triphosphatase Homo sapiens 131-158 19055736-3 2008 Deoxyuridine triphosphatase (dUTPase) hydrolyzes dUTP, generating dUMP for biosynthesis of thymidine nucleotides while decreasing the availability of dUTP for misincorporation; uracil DNA glycosylase (UNG) cleaves uracil N-glycosylic bonds in DNA initiating base excision repair. Uracil 177-183 deoxyuridine triphosphatase Homo sapiens 0-27 28073829-5 2017 DUT is a key enzyme for maintaining DNA integrity by preventing misincorporation of uracil into DNA, which results in DNA toxicity and cell death. Uracil 84-90 deoxyuridine triphosphatase Homo sapiens 0-3 22404301-0 2012 Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors. Uracil 86-92 deoxyuridine triphosphatase Homo sapiens 121-148