PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22414725-8	2012	In addition, a docking model predicted the binding conformation of GW583340 and GW2974 to be within the transmembrane region of homology modeled human ABCB1 and ABCG2.	GW2974	80-86	ATP binding cassette subfamily B member 1	Homo sapiens	151-156	
22414725-9	2012	We conclude that GW583340 and GW2974, at clinically achievable plasma concentrations, reverse ABCB1- and ABCG2-mediated MDR by blocking the drug efflux function of these transporters.	GW2974	30-36	ATP binding cassette subfamily B member 1	Homo sapiens	94-99	
22414725-0	2012	GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.	GW2974	13-19	ATP binding cassette subfamily B member 1	Homo sapiens	73-78	
22414725-3	2012	In the present study, we conducted in vitro experiments to evaluate if GW583340 and GW2974, structural analogues of lapatinib, could reverse ABCB1- and ABCG2-mediated MDR.	GW2974	84-90	ATP binding cassette subfamily B member 1	Homo sapiens	141-146	
22414725-4	2012	Our results showed that GW583340 and GW2974 significantly sensitized ABCB1 and ABCG2 overexpressing MDR cells to their anticancer substrates.	GW2974	37-43	ATP binding cassette subfamily B member 1	Homo sapiens	69-74	
22414725-5	2012	GW583340 and GW2974 significantly increased the intracellular accumulation of [(3)H]-paclitaxel in ABCB1 overexpressing cells and [(3)H]-mitoxantrone in ABCG2 overexpressing cells respectively.	GW2974	13-19	ATP binding cassette subfamily B member 1	Homo sapiens	99-104