PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17556544-2 2007 Here, we show that GW2974 (HER2/EGF receptor tyrosine kinase inhibitor), but not trastuzumab, activates AMP-activated protein kinase (AMPK), initiating a metabolic stress response in human cardiomyocytes that protects against TNFalpha-induced cell death. GW2974 19-25 ret proto-oncogene Homo sapiens 36-60 16934227-4 2006 We have shown that the RTK inhibitor GW282974A (an analogue of GW2016; lapatinib) is effective in chemosensitisation of drug resistant EGFR over-expressing cells giving rise to a synergistic effect when used in combination with either cisplatin or paclitaxel in chemosensitivity assays. GW2974 37-46 ret proto-oncogene Homo sapiens 23-26