PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35452603-3 2022 We then use orthogonal approaches to increase binding on both the tumor and CAR-T cell sides of the immune synapse: a pharmacologic approach (azacitidine) to increase antigen density of CD70 in myeloid tumors, and an engineering approach to stabilize binding of the CAR to CD70. Azacitidine 142-153 nuclear receptor subfamily 1 group I member 3 Homo sapiens 76-79 33954150-0 2021 Priming Leukemia with 5-Azacytidine Enhances CAR T Cell Therapy. Azacitidine 22-35 nuclear receptor subfamily 1 group I member 3 Homo sapiens 45-48 33954150-4 2021 Priming leukemia cells with AZA increased CAR T cell/target cell conjugation and target cell killing, promoted CAR T cell divisions and expanded IFNgamma+ effector T cells in co-cultures with CD19+ leukemia Nalm-6 and Raji cells. Azacitidine 28-31 nuclear receptor subfamily 1 group I member 3 Homo sapiens 42-45 33954150-4 2021 Priming leukemia cells with AZA increased CAR T cell/target cell conjugation and target cell killing, promoted CAR T cell divisions and expanded IFNgamma+ effector T cells in co-cultures with CD19+ leukemia Nalm-6 and Raji cells. Azacitidine 28-31 nuclear receptor subfamily 1 group I member 3 Homo sapiens 111-114 33954150-11 2021 Conclusion: We propose that treatment with AZA activates OX40L/OX40 co-stimulatory signaling in CAR T cells. Azacitidine 43-46 nuclear receptor subfamily 1 group I member 3 Homo sapiens 96-99