PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15107420-4	2004	5-Aza-deoxycytidine treatment induced the expression of the ChM-I gene in ChM-I-negative OS cell lines, and the induction of expression was associated tightly with the demethylation of cytosine at -52 (C(-52)) in the middle of an Sp1/3 binding site to which the Sp3, but not Sp1, bound.	Azacitidine	0-5	Sp3 transcription factor	Homo sapiens	262-265	
11443124-0	2001	5-azaC treatment enhances expression of transforming growth factor-beta receptors through down-regulation of Sp3.	Azacitidine	0-6	Sp3 transcription factor	Homo sapiens	109-112	
11443124-2	2001	We now present data suggesting that treatment of MCF-7L breast and GEO colon cancer cells with 5-aza cytidine (5-azaC) leads to down-regulation of Sp3 and the concomitant induction of RI and RII.	Azacitidine	95-109	Sp3 transcription factor	Homo sapiens	147-150	
11443124-2	2001	We now present data suggesting that treatment of MCF-7L breast and GEO colon cancer cells with 5-aza cytidine (5-azaC) leads to down-regulation of Sp3 and the concomitant induction of RI and RII.	Azacitidine	111-117	Sp3 transcription factor	Homo sapiens	147-150	
11443124-3	2001	Western blot and gel shift analyses on 5-azaC-treated MCF-7L and GEO nuclear extracts indicated reduced Sp3 protein levels and decreased binding of Sp3 protein to radiolabeled consensus Sp1 oligonucleotide.	Azacitidine	39-45	Sp3 transcription factor	Homo sapiens	104-107	
11443124-3	2001	Western blot and gel shift analyses on 5-azaC-treated MCF-7L and GEO nuclear extracts indicated reduced Sp3 protein levels and decreased binding of Sp3 protein to radiolabeled consensus Sp1 oligonucleotide.	Azacitidine	39-45	Sp3 transcription factor	Homo sapiens	148-151	
11443124-4	2001	Southwestern analysis detected decreased binding of Sp3 to RI and RII promoters in 5-azaC-treated MCF-7L and GEO cells, suggesting a correlation between decreased Sp3 binding and enhanced RI and RII expression in these cells.	Azacitidine	83-89	Sp3 transcription factor	Homo sapiens	52-55	
11443124-4	2001	Southwestern analysis detected decreased binding of Sp3 to RI and RII promoters in 5-azaC-treated MCF-7L and GEO cells, suggesting a correlation between decreased Sp3 binding and enhanced RI and RII expression in these cells.	Azacitidine	83-89	Sp3 transcription factor	Homo sapiens	163-166	
11443124-5	2001	Reverse transcription-polymerase chain reaction and nuclear run-on data from 5-azaC-treated MCF-7L and GEO cells indicated down-regulation of Sp3 mRNA as a result of decreased transcription of Sp3.	Azacitidine	77-83	Sp3 transcription factor	Homo sapiens	142-145	
11443124-5	2001	Reverse transcription-polymerase chain reaction and nuclear run-on data from 5-azaC-treated MCF-7L and GEO cells indicated down-regulation of Sp3 mRNA as a result of decreased transcription of Sp3.	Azacitidine	77-83	Sp3 transcription factor	Homo sapiens	193-196	
11443124-7	2001	These studies demonstrate that the effect of 5-azaC involves a combination of effects on Sp1 and Sp3.	Azacitidine	45-51	Sp3 transcription factor	Homo sapiens	97-100