PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22356238-3 2012 We assessed the ability of azacitidine, decitabine, and, for comparison, gemcitabine, to interact with human nucleoside transporters (hNTs) in Saccharomyces cerevisiae cells (hENT1/2, hCNT1/2/3) or Xenopus laevis oocytes (hENT3/4). Azacitidine 27-38 solute carrier family 28 member 1 Homo sapiens 184-193 19139132-9 2009 hCNT1-expressing cells were significantly more sensitive to 5-azaCyd, and drug-dependent covalent trapping of DNA methyltransferase 1 was substantially more pronounced. Azacitidine 60-68 solute carrier family 28 member 1 Homo sapiens 0-5 19139132-10 2009 Importantly, these results correlated with a significant sensitization of hCNT1-expressing cells toward the demethylating effects of 5-azaCyd and 5-aza-2"-deoxycytidine. Azacitidine 133-141 solute carrier family 28 member 1 Homo sapiens 74-79 19139132-11 2009 In conclusion, our study identifies 5-azaCyd as a novel substrate for hCNT1 and provides direct evidence that hCNT1 is involved in the DNA-demethylating effects of this drug. Azacitidine 36-44 solute carrier family 28 member 1 Homo sapiens 70-75