PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27029827-2	2017	Our previous study showed that DNA demethylating agent Azacitidine (Aza) demethylated CpG sites in paired box gene 5 (pax5) promoter region, but did not induce pax5 mRNA or protein expression.	Azacitidine	55-66	paired box 5	Homo sapiens	99-116	
21779426-5	2010	They then show that expression of all 3 genes is restored in T98 GBM cells by treatment with the histone deacetylase inhibitor Trichostatin A (TSA), but only DKK1 expression is restored by treatment with the demethylating agent 5-azacytidine.	Azacitidine	228-241	paired box 5	Homo sapiens	34-39	
27029827-2	2017	Our previous study showed that DNA demethylating agent Azacitidine (Aza) demethylated CpG sites in paired box gene 5 (pax5) promoter region, but did not induce pax5 mRNA or protein expression.	Azacitidine	55-66	paired box 5	Homo sapiens	118-122	
27029827-2	2017	Our previous study showed that DNA demethylating agent Azacitidine (Aza) demethylated CpG sites in paired box gene 5 (pax5) promoter region, but did not induce pax5 mRNA or protein expression.	Azacitidine	55-58	paired box 5	Homo sapiens	99-116	
27029827-2	2017	Our previous study showed that DNA demethylating agent Azacitidine (Aza) demethylated CpG sites in paired box gene 5 (pax5) promoter region, but did not induce pax5 mRNA or protein expression.	Azacitidine	55-58	paired box 5	Homo sapiens	118-122	
27029827-4	2017	We treated pax5- silenced NSCLC H460 cells with Aza+SAHA combination at sub-toxic concentration and detected the re-expression of pax5 mNRA and protein.	Azacitidine	48-51	paired box 5	Homo sapiens	11-15	
27029827-4	2017	We treated pax5- silenced NSCLC H460 cells with Aza+SAHA combination at sub-toxic concentration and detected the re-expression of pax5 mNRA and protein.	Azacitidine	48-51	paired box 5	Homo sapiens	130-134	
27029827-5	2017	RESULTS: The results showed demethylation of CpG sites in pax5 promoter region by Aza treatment and increased DNA accessibility for protein binding by SAHA treatment.	Azacitidine	82-85	paired box 5	Homo sapiens	58-62	
27029827-6	2017	The combination of Aza+SAHA significantly increased p53 protein binding to DNA in pax5 promoter region (p<0.01).	Azacitidine	19-22	paired box 5	Homo sapiens	82-86	
27029827-7	2017	More efficient binding of the transcription factor p53 to pax5 promoter region is likely because SAHA increased accessibility of the chromatin conformation and Aza-demethylated DNA was more permissive, allowing transcription factors to bind.	Azacitidine	160-163	paired box 5	Homo sapiens	58-62	
27029827-8	2017	CONCLUSION: Our study not only explained an underlying mechanism, that pax5 re-expression was induced by Aza+SAHA combination in H460 cells via p53, but also demonstrated a pattern showing that the combination of demethylating agent and HDAC inhibitor can re-activate tumor suppressor gene (TSG) which is associated with the enhancement of transcription factors binding to the promoter region of the TSG.	Azacitidine	105-108	paired box 5	Homo sapiens	71-75