PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16202213-11	2005	The effect of TSA on hTERT expression is independent of DNA methylation as judged by 5-azacytidine (5aza) treatment.	Azacitidine	85-98	telomerase reverse transcriptase	Homo sapiens	21-26	
19451745-5	2009	RESULTS: Demethylation by 5-azacytidine resulted in hTERT inhibition with a reduction in telomerase activity to 37-49% of controls.	Azacitidine	26-39	telomerase reverse transcriptase	Homo sapiens	52-57	
25682873-5	2015	Telomere dysfunction was coupled with diminished TERT expression, shorter telomere and apoptosis in 5-AZA-treated cells.	Azacitidine	100-105	telomerase reverse transcriptase	Homo sapiens	49-53	
25682873-7	2015	Down-regulation of TERT expression similarly occurred in primary leukemic cells derived from AML patients exposed to 5-AZA.	Azacitidine	117-122	telomerase reverse transcriptase	Homo sapiens	19-23	
25682873-8	2015	TERT over-expression significantly attenuated 5-AZA-mediated DNA damage, telomere dysfunction and apoptosis of AML cells.	Azacitidine	46-51	telomerase reverse transcriptase	Homo sapiens	0-4	
25682873-9	2015	Collectively, 5-AZA mediates the down-regulation of TERT expression, and induces telomere dysfunction, which consequently exerts an anti-tumor activity.	Azacitidine	14-19	telomerase reverse transcriptase	Homo sapiens	52-56	
16202213-11	2005	The effect of TSA on hTERT expression is independent of DNA methylation as judged by 5-azacytidine (5aza) treatment.	Azacitidine	100-104	telomerase reverse transcriptase	Homo sapiens	21-26	
12810068-5	2003	After methylation patterns had been established within the hTERT promoter region in late differentiating cells, 5-azacytidine, a common demethylating agent, activated the hTERT gene but trichostatin A had no effect on hTERT transcription.	Azacitidine	112-125	telomerase reverse transcriptase	Homo sapiens	59-64	
12810068-5	2003	After methylation patterns had been established within the hTERT promoter region in late differentiating cells, 5-azacytidine, a common demethylating agent, activated the hTERT gene but trichostatin A had no effect on hTERT transcription.	Azacitidine	112-125	telomerase reverse transcriptase	Homo sapiens	171-176	
12810068-5	2003	After methylation patterns had been established within the hTERT promoter region in late differentiating cells, 5-azacytidine, a common demethylating agent, activated the hTERT gene but trichostatin A had no effect on hTERT transcription.	Azacitidine	112-125	telomerase reverse transcriptase	Homo sapiens	171-176	
10914736-0	2000	Demethylating reagent 5-azacytidine inhibits telomerase activity in human prostate cancer cells through transcriptional repression of hTERT.	Azacitidine	22-35	telomerase reverse transcriptase	Homo sapiens	134-139	
10914736-7	2000	Transient expression assays showed that 5-aza-CR repressed the transcriptional activity of the hTERT promoter and that the E-box within the core promoter was responsible for this down-regulation.	Azacitidine	40-48	telomerase reverse transcriptase	Homo sapiens	95-100	
10914736-10	2000	These findings suggest that 5-aza-CR inhibits telomerase activity via transcriptional repression of hTERT, in which p16 and c-Myc may play a key role.	Azacitidine	28-36	telomerase reverse transcriptase	Homo sapiens	100-105	
10676632-5	2000	Demethylation of DNA with 5-azacytidine in two cell lines induced expression of hTERT, suggesting that DNA methylation can contribute to hTERT repression in some cells.	Azacitidine	26-39	telomerase reverse transcriptase	Homo sapiens	80-85	
10676632-5	2000	Demethylation of DNA with 5-azacytidine in two cell lines induced expression of hTERT, suggesting that DNA methylation can contribute to hTERT repression in some cells.	Azacitidine	26-39	telomerase reverse transcriptase	Homo sapiens	137-142	
34765562-3	2021	We previously reported that Histone deacetylase inhibitors (HDACi, romidespin and vorinostat) and a DNA methyltransferase inhibitor (DNMTi, 5-azacytidine) can reduce hTERT expression without altering the methylation level of hTERT promoter.	Azacitidine	140-153	telomerase reverse transcriptase	Homo sapiens	166-171	
32394848-0	2021	Azacitidine, as a DNMT inhibitor decreases hTERT gene expression and telomerase activity more effective compared with HDAC inhibitor in human Head and neck squamous cell carcinoma cell lines.	Azacitidine	0-11	telomerase reverse transcriptase	Homo sapiens	43-48	
32394848-7	2021	The results showed that Azacitidine significantly decreased hTERT gene expression and telomerase activity in FaDu and Cal-27 cell lines.	Azacitidine	24-35	telomerase reverse transcriptase	Homo sapiens	60-65	
32082377-12	2019	Furthermore, H. pylori appears to downregulate TERT gene expression through DNA hypermethylation as shown by the restoration of TERT transcript levels in cells treated with 5"-azacytidine, an inhibitor of DNA methylation.	Azacitidine	173-187	telomerase reverse transcriptase	Homo sapiens	47-51	
32082377-12	2019	Furthermore, H. pylori appears to downregulate TERT gene expression through DNA hypermethylation as shown by the restoration of TERT transcript levels in cells treated with 5"-azacytidine, an inhibitor of DNA methylation.	Azacitidine	173-187	telomerase reverse transcriptase	Homo sapiens	128-132