PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29122665-3	2018	The intracellular accumulation of rhodamine 123 (a classic P-gp substrate) and of several commonly used AEDs (carbamazepine, phenytoin, oxcarbazepine) or their metabolites (carbamazepine-10,11-epoxide and licarbazepine) was evaluated in MDCK-MDR1 cells in the presence and absence of individual flavonoids and their combinations.	Rhodamine 123	34-47	PGP	Canis lupus familiaris	59-63	
29389596-6	2018	Overall, the results showed that baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin, at 200muM, produced a marked increase on the intracellular accumulation of rhodamine 123 in MDCK-MDR1 cells, potentially through inhibiting the P-gp activity.	Rhodamine 123	186-199	PGP	Canis lupus familiaris	255-259	
15067695-3	2004	The P-gp inhibitor GF-120918 could significantly reduce the polarized efflux of both rhodamine 123 and Hoechst 33342.	Rhodamine 123	85-98	PGP	Canis lupus familiaris	4-8	
25600546-4	2015	P-gp activity was determined by rhodamine 123 (Rho 123) efflux inhibited by verapamil and MRP by 5(6) carboxyfluorescein diacetate (CFDA) efflux inhibited by probenecid.	Rhodamine 123	32-45	PGP	Canis lupus familiaris	0-4	
17339753-4	2007	P-gp expression was also examined by Western blot analysis, while the functional activity of P-gp was assessed by flowcytometric analysis of intracellular rhodamine-123 (Rhd-123) uptake.	Rhodamine 123	155-168	PGP	Canis lupus familiaris	93-97	
16223335-7	2005	Treatment with 100 mM MbetaCD did not affect viability but altered the structural appearance of the cells and abolished efflux of rhodamine 123, a P-gp substrate.	Rhodamine 123	130-143	PGP	Canis lupus familiaris	147-151	
27886150-6	2016	P-gp efflux activity and P-gp ATPase activity were measured using a rhodamine 123 (Rh-123) accumulation assay and a Pgp-Glo  assay; respectively.	Rhodamine 123	83-89	PGP	Canis lupus familiaris	0-4	
27572343-7	2016	Pig P-gp was successfully stably overexpressed in MDCK cells and had efflux activity for rhodamine 123, a substrate of P-gp.	Rhodamine 123	89-102	PGP	Canis lupus familiaris	4-8	
27572343-7	2016	Pig P-gp was successfully stably overexpressed in MDCK cells and had efflux activity for rhodamine 123, a substrate of P-gp.	Rhodamine 123	89-102	PGP	Canis lupus familiaris	119-123	
27642311-10	2016	The widely used rhodamine-123 transport assay performed in the MDCK cells demonstrated the presence of P-glycoprotein in this model.	Rhodamine 123	16-29	PGP	Canis lupus familiaris	103-117	
24975508-4	2014	This sub-cell line was more resistant to doxorubicin and vincristine, but not to prednisolone, and had a highly increased P-glycoprotein (P-gp/abcb1) expression and transport capacity for the P-gp model-substrate rhodamine123.	Rhodamine 123	213-225	PGP	Canis lupus familiaris	138-142	
24975508-5	2014	Both resistance to doxorubicin and vincristine, and rhodamine123 transport capacity were fully reversed by the P-gp inhibitor PSC833.	Rhodamine 123	52-64	PGP	Canis lupus familiaris	111-115	
18828688-4	2008	The P-gp and MRP activities were assessed by measuring cellular retention of rhodamine 123 and 5(6)-carboxyfluorescein diacetate in the absence and presence of inhibitors (verapamil and PSC833 for P-gp, probenecid and MK-571 for MRP).	Rhodamine 123	77-90	PGP	Canis lupus familiaris	4-8	
15639447-1	2005	Rhodamine 123 (R123) is widely used to quantify P-glycoprotein (P-GP) functional efflux activity in vitro.	Rhodamine 123	0-13	PGP	Canis lupus familiaris	48-62	
15639447-1	2005	Rhodamine 123 (R123) is widely used to quantify P-glycoprotein (P-GP) functional efflux activity in vitro.	Rhodamine 123	0-13	PGP	Canis lupus familiaris	64-68	
15067695-13	2004	In conclusion, these bidirectional transport data indicate that rhodamine 123 and Hoechst 33342 are excellent substrates of P-gp in MDCK-MDR1 cells.	Rhodamine 123	64-77	PGP	Canis lupus familiaris	124-128	
15067695-14	2004	The ability of Hoechst 33342 to partially inhibit the polarized efflux of rhodamine 123 is consistent with these substrates binding to the same site on P-gp.	Rhodamine 123	74-87	PGP	Canis lupus familiaris	152-156	
15067695-15	2004	In contrast, the ability of rhodamine 123 to apparently "stimulate" the efflux of Hoechst 33342 in both the transport and uptake experiments suggests the substrates might bind to different sites on P-gp.	Rhodamine 123	28-41	PGP	Canis lupus familiaris	198-202	
12761814-5	2003	P-gp-mediated rhodamine 123 transport was inhibited by five nonionic surfactants in a concentration-dependent manner and in the order TPGS > Pluronic PE8100 > Cremophor EL > Pluronic PE6100 approximately Tween 80.	Rhodamine 123	14-27	PGP	Canis lupus familiaris	0-4	
11121735-7	2000	Efflux of the P-gp substrate rhodamine123 (rho123) was monitored with confocal laser scanning microscopy (CLSM).	Rhodamine 123	29-41	PGP	Canis lupus familiaris	14-18	
11121735-7	2000	Efflux of the P-gp substrate rhodamine123 (rho123) was monitored with confocal laser scanning microscopy (CLSM).	Rhodamine 123	43-49	PGP	Canis lupus familiaris	14-18