PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9085043-1 1997 Rhodamine 123 has been shown to be a substrate for P-glycoprotein in multidrug resistant cells. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 51-65 9619778-7 1998 P-gp mediated transport activity was assessed by measuring the verapamil-inhibitable efflux of rhodamine 123 (R123) in freshly isolated hepatocytes. Rhodamine 123 95-108 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 9535788-4 1998 In addition, the DNA-damaging agent was found to enhance in a dose-dependent manner cellular efflux of the P-gp substrate rhodamine 123, which was inhibited by the P-gp inhibitor verapamil, thus providing evidence that exposure to MMS led to increased P-gp-related drug transport in rat liver cells. Rhodamine 123 122-135 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 107-111 9535788-4 1998 In addition, the DNA-damaging agent was found to enhance in a dose-dependent manner cellular efflux of the P-gp substrate rhodamine 123, which was inhibited by the P-gp inhibitor verapamil, thus providing evidence that exposure to MMS led to increased P-gp-related drug transport in rat liver cells. Rhodamine 123 122-135 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 164-168 9535788-4 1998 In addition, the DNA-damaging agent was found to enhance in a dose-dependent manner cellular efflux of the P-gp substrate rhodamine 123, which was inhibited by the P-gp inhibitor verapamil, thus providing evidence that exposure to MMS led to increased P-gp-related drug transport in rat liver cells. Rhodamine 123 122-135 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 164-168 9395229-7 1997 In a competitive transport assay, verapamil and, to a lesser extent, colchicine blocked the increased efflux of the fluorescent dye rhodamine 123 from mdr1b-transfected cells, whereas aflatoxin B1 did not compete for this export. Rhodamine 123 132-145 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 151-156 9210482-6 1997 Moreover, doxorubicin-treated RLE cells displayed enhanced cellular efflux of the P-glycoprotein substrate rhodamine 123 that was inhibited by the P-glycoprotein blocker verapamil, thus providing evidence that doxorubicin-induced P-glycoprotein was functional in liver cells. Rhodamine 123 107-120 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 82-96 9210482-6 1997 Moreover, doxorubicin-treated RLE cells displayed enhanced cellular efflux of the P-glycoprotein substrate rhodamine 123 that was inhibited by the P-glycoprotein blocker verapamil, thus providing evidence that doxorubicin-induced P-glycoprotein was functional in liver cells. Rhodamine 123 107-120 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 147-161 9210482-6 1997 Moreover, doxorubicin-treated RLE cells displayed enhanced cellular efflux of the P-glycoprotein substrate rhodamine 123 that was inhibited by the P-glycoprotein blocker verapamil, thus providing evidence that doxorubicin-induced P-glycoprotein was functional in liver cells. Rhodamine 123 107-120 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 147-161 9651124-3 1998 In both freshly-plated hepatocytes, containing low levels of Pgp, and 72 hour-cultured hepatocytes, containing high levels of Pgp, the Rhodamine-123 (R-123) efflux, which represents a specific functional test for Pgp-mediated transport, was inhibited by curcumin in a dose-dependent manner. Rhodamine 123 135-148 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 126-129 9651124-3 1998 In both freshly-plated hepatocytes, containing low levels of Pgp, and 72 hour-cultured hepatocytes, containing high levels of Pgp, the Rhodamine-123 (R-123) efflux, which represents a specific functional test for Pgp-mediated transport, was inhibited by curcumin in a dose-dependent manner. Rhodamine 123 135-148 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 126-129 9085043-6 1997 However, pretreatment of the kidneys with verapamil and quinidine (inhibitors of both P-glycoprotein and organic cation transport) or cimetidine (organic cation transport inhibitor) resulted in a significantly reduced rhodamine 123 clearance, indicating that the renal organic cation carrier may be involved in active secretion. Rhodamine 123 218-231 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 86-100 7475916-1 1995 The effects of flavonols on P-glycoprotein (Pgp) activity were studied in cultured rat hepatocytes by assessing and transmembrane transport of Rhodamine-123 (R-123) and doxorubicin (DOX). Rhodamine 123 143-156 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 44-47 9079744-7 1997 Furthermore, the fluorescent P-glycoprotein substrate rhodamine-123 was effectively pumped out of the four tested hormone-independent cell lines, whereas the hormone-sensitive G cells were unable to extrude the dye. Rhodamine 123 54-67 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 29-43 8630083-4 1996 In addition, MC-induced P-gp appeared to be fully functional because RLE cells exposed to MC displayed enhanced cellular efflux of rhodamine 123, a known P-gp substrate, compared to their untreated counterparts. Rhodamine 123 131-144 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 24-28 8630083-4 1996 In addition, MC-induced P-gp appeared to be fully functional because RLE cells exposed to MC displayed enhanced cellular efflux of rhodamine 123, a known P-gp substrate, compared to their untreated counterparts. Rhodamine 123 131-144 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 154-158 7575588-2 1995 In primary rat hepatocytes maintained in serum-free culture, accumulation of immunodetectable P-glycoprotein and mdr1b mRNA occurred in a time-dependent manner and was accompanied by a substantial decrease in retention of the mdr1 substrate rhodamine 123. Rhodamine 123 241-254 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 113-118 7598699-0 1995 Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats. Rhodamine 123 78-91 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 14-28 7598699-2 1995 This study examined the effect of a p-glycoprotein inhibitor, cyclosporin A, on the distribution to the brain of a p-glycoprotein substrate, rhodamine-123, in freely moving rats using intracerebral microdialysis coupled with on-line HPLC analysis. Rhodamine 123 141-154 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 36-50 7598699-2 1995 This study examined the effect of a p-glycoprotein inhibitor, cyclosporin A, on the distribution to the brain of a p-glycoprotein substrate, rhodamine-123, in freely moving rats using intracerebral microdialysis coupled with on-line HPLC analysis. Rhodamine 123 141-154 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 115-129 7598699-4 1995 The plasma disposition of rhodamine-123 was unchanged by cyclosporin A, indicating that the change in brain exposure was mediated by a process at the level of the blood-brain barrier, possibly by inhibition of the p-glycoprotein efflux transporter. Rhodamine 123 26-39 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 214-228 33557872-5 2021 METHODS: In the present study PGP substrate rhodamine-123 (R123) was injected intraperitoneally into E19 dams, postnatal (P4, P14) and adult rats. Rhodamine 123 44-57 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 30-33 34530005-4 2021 The inhibition study with quinidine clearly indicated that the decrease in secretory clearance of R-123 by adrenaline or the increase by DBcAMP would be attributed to the decrease or increase in P-gp activity, respectively. Rhodamine 123 98-103 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 195-199 7912496-1 1994 The interaction between P-glycoprotein modulators and P-glycoprotein mediated transport was investigated using rhodamine 123 in the isolated perfused rat liver of a mutant (TR-) rat strain. Rhodamine 123 111-124 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 54-68 34506838-5 2021 Hepatic P-gp expression and activity were evaluated by western blotting and using rhodamine 123 as substrate in vivo, respectively. Rhodamine 123 82-95 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 8-12 35379125-2 2022 METHODS: The transport of daclatasvir, as well as the standard rhodamine 123 by P-gp across the rat intestine, was studied in vitro using the non-everted sac method. Rhodamine 123 63-76 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 80-84 33557872-5 2021 METHODS: In the present study PGP substrate rhodamine-123 (R123) was injected intraperitoneally into E19 dams, postnatal (P4, P14) and adult rats. Rhodamine 123 59-63 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 30-33 32583315-5 2020 In the present study, rhodamine 123 (Rho123) was selected as the P-gp substrate, and the effects of pharmaceutical excipients on its membrane transport in the rat jejunum and ileum were examined. Rhodamine 123 22-35 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 65-69 32583315-5 2020 In the present study, rhodamine 123 (Rho123) was selected as the P-gp substrate, and the effects of pharmaceutical excipients on its membrane transport in the rat jejunum and ileum were examined. Rhodamine 123 37-43 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 65-69 32522680-7 2020 The net secretion of the P-gp substrate Rh123 across the rat duodenum was increased in the presence of MLs. Rhodamine 123 40-45 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 25-29 31756430-5 2020 The efflux of rhodamine 123 (300 muM), a P-gp fluorescent substrate, significantly increased in TX5-treated everted sacs from the distal portion of the rat ileum, when P-gp activity was evaluated in the presence of TX5 (20 muM), an effect abolished by the P-gp inhibitor verapamil (100 muM). Rhodamine 123 14-27 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 41-45 32187961-7 2020 In an intracellular accumulation experiment using Rhodamine 123 as a P-gp substrate, genistein significantly increased the intracellular fluorescence of Rhodamine 123. Rhodamine 123 50-63 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 69-73 32187961-7 2020 In an intracellular accumulation experiment using Rhodamine 123 as a P-gp substrate, genistein significantly increased the intracellular fluorescence of Rhodamine 123. Rhodamine 123 153-166 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 69-73 32131933-2 2020 Methods rBMECs were exposed to L-glutamate(100 mumol/L) for 30 mins to induce the overexpression of P-gp/multidrug resistance gene 1a(Mdr1a)on the cell membranes,which mimicked the overexpression of P-gp/Mdr1a in blood brain barrier(BBB) when drug-resistant epilepsy attacked.MTT assay was used to detect the safe range of alpha-asarone concentration.The model cells were intervened with different concentrations of alpha-asarone at 12.5,25.0,and 50.0 mug/mul for 24 hours.After the treatment of alpha-asarone,the expression and the function of P-gp/Mdr1 were measured by Western blotting,real-time PCR,and intracellular rhodamine 123 accumulation assays. Rhodamine 123 621-634 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 134-138 32185415-7 2020 Hepatic P-gp activity measured with rhodamine-123 and digoxin, both well-known P-gp substrates, was also increased. Rhodamine 123 36-49 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 8-12 31756430-5 2020 The efflux of rhodamine 123 (300 muM), a P-gp fluorescent substrate, significantly increased in TX5-treated everted sacs from the distal portion of the rat ileum, when P-gp activity was evaluated in the presence of TX5 (20 muM), an effect abolished by the P-gp inhibitor verapamil (100 muM). Rhodamine 123 14-27 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 168-172 31756430-5 2020 The efflux of rhodamine 123 (300 muM), a P-gp fluorescent substrate, significantly increased in TX5-treated everted sacs from the distal portion of the rat ileum, when P-gp activity was evaluated in the presence of TX5 (20 muM), an effect abolished by the P-gp inhibitor verapamil (100 muM). Rhodamine 123 14-27 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 168-172 25152622-11 2014 Incorporating another P-gp substrate (Rhodamine 123) into P123 micelles also showed higher efficiency in penetrating the BBB in vitro and in vivo. Rhodamine 123 38-51 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 22-26 27000241-6 2016 Further results revealed that Z-guggulsterone (50mg/kg) significantly increased the accumulation of rhodamine 123 by down-regulating P-glycoprotein expression in rat brain, as compared with control (P<0.05). Rhodamine 123 100-113 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 133-147 26102179-8 2015 Further studies revealed that the uptake of rhodamine 123 (Rho123) in diabetic rats was significantly higher, indicating that diabetes mellitus might impair P-gp function. Rhodamine 123 44-57 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 157-161 24998179-13 2014 Brain endothelial cells organized in monolayers expressed the efflux transporter P-glycoprotein (P-gp), showed a polarized transport of rhodamine 123, a ligand for P-gp, and showed specific transport of transferrin-Cy3 and DiILDL across the endothelial cell monolayer. Rhodamine 123 136-149 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 81-95 24912442-8 2014 The biliary excretion of rhodamine 123 was decreased in rats with chronic inflammation owing to decreases in efflux activities of P-gp. Rhodamine 123 25-38 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 130-134 24998179-13 2014 Brain endothelial cells organized in monolayers expressed the efflux transporter P-glycoprotein (P-gp), showed a polarized transport of rhodamine 123, a ligand for P-gp, and showed specific transport of transferrin-Cy3 and DiILDL across the endothelial cell monolayer. Rhodamine 123 136-149 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 97-101 24998179-13 2014 Brain endothelial cells organized in monolayers expressed the efflux transporter P-glycoprotein (P-gp), showed a polarized transport of rhodamine 123, a ligand for P-gp, and showed specific transport of transferrin-Cy3 and DiILDL across the endothelial cell monolayer. Rhodamine 123 136-149 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 164-168 23791640-4 2013 In another experiment, rhodamine 123 was used to quantify the biliary canalicular transporter P-glycoprotein (P-gp, Abcb1a/b) with cyclosporin A as an inhibitor of P-gp activity. Rhodamine 123 23-36 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 94-108 23991219-5 2013 P-gp function was evaluated by flow cytometry measuring the accumulation of rhodamine123. Rhodamine 123 76-88 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 24424534-4 2014 The cell system exhibited high functional activity and a net efflux ratio (NER) of 4.32 after transport of Rhodamine 123 (R123) (the P-gp substrate). Rhodamine 123 107-120 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 133-137 24065596-0 2014 Effects of hepatic ischemia-reperfusion injury on the P-glycoprotein activity at the liver canalicular membrane and blood-brain barrier determined by in vivo administration of rhodamine 123 in rats. Rhodamine 123 176-189 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 54-68 24065596-1 2014 PURPOSE: To investigate the effects of normothermic hepatic ischemia-reperfusion (IR) injury on the activity of P-glycoprotein (P-gp) in the liver and at the blood-brain barrier (BBB) of rats using rhodamine 123 (RH-123) as an in vivo marker. Rhodamine 123 198-211 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 112-126 24065596-1 2014 PURPOSE: To investigate the effects of normothermic hepatic ischemia-reperfusion (IR) injury on the activity of P-glycoprotein (P-gp) in the liver and at the blood-brain barrier (BBB) of rats using rhodamine 123 (RH-123) as an in vivo marker. Rhodamine 123 198-211 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 128-132 24065596-1 2014 PURPOSE: To investigate the effects of normothermic hepatic ischemia-reperfusion (IR) injury on the activity of P-glycoprotein (P-gp) in the liver and at the blood-brain barrier (BBB) of rats using rhodamine 123 (RH-123) as an in vivo marker. Rhodamine 123 213-219 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 112-126 24065596-1 2014 PURPOSE: To investigate the effects of normothermic hepatic ischemia-reperfusion (IR) injury on the activity of P-glycoprotein (P-gp) in the liver and at the blood-brain barrier (BBB) of rats using rhodamine 123 (RH-123) as an in vivo marker. Rhodamine 123 213-219 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 128-132 24735764-4 2014 Rhodamine 123 is a fluorescent substrate of P-glycoprotein and its hepatic disposition can be visualized using multiphoton microscopy in vivo using anaesthetized animals. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 44-58 23916719-4 2013 We observed that rhodamine 123 is subject to p-glycoprotein mediated efflux at the rat BBB and can be increased nearly 20-fold with p-glycoprotein inhibition. Rhodamine 123 17-30 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 45-59 23916719-4 2013 We observed that rhodamine 123 is subject to p-glycoprotein mediated efflux at the rat BBB and can be increased nearly 20-fold with p-glycoprotein inhibition. Rhodamine 123 17-30 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 132-146 23670704-4 2013 Data from all three models show inhibition of P-gp increases the extent of absorption of a subset of P-gp substrates (e.g. rhodamine 123 and loperamide) whose physico-chemical properties are distinct from those whose pulmonary absorption remained unaffected (e.g. digoxin and saquinavir). Rhodamine 123 123-136 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 46-50 23670704-4 2013 Data from all three models show inhibition of P-gp increases the extent of absorption of a subset of P-gp substrates (e.g. rhodamine 123 and loperamide) whose physico-chemical properties are distinct from those whose pulmonary absorption remained unaffected (e.g. digoxin and saquinavir). Rhodamine 123 123-136 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 101-105 23791640-4 2013 In another experiment, rhodamine 123 was used to quantify the biliary canalicular transporter P-glycoprotein (P-gp, Abcb1a/b) with cyclosporin A as an inhibitor of P-gp activity. Rhodamine 123 23-36 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 110-114 22652439-1 2012 Magnetic nanoparticles (NP) were developed for the active brain targeting of water-soluble P-glycoprotein (P-gp) substrate rhodamine 123 (Rh123). Rhodamine 123 123-136 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 91-105 22850759-3 2013 In addition, P-gp activity in each segment was evaluated in terms of permeability of rhodamine123 (Rho123), a typical P-gp substrate, using the serial intestinal non-everted sac method. Rhodamine 123 85-97 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 13-17 23383092-9 2013 Verapamil (a P-gp inhibitor) significantly increased the influx of rhodamine 123, supporting functional P-gp expression in the neonatal BBB model. Rhodamine 123 67-80 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 13-17 23383092-9 2013 Verapamil (a P-gp inhibitor) significantly increased the influx of rhodamine 123, supporting functional P-gp expression in the neonatal BBB model. Rhodamine 123 67-80 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 104-108 23685082-5 2013 Non-P-gp-related rhodamine 123 accumulation was evaluated using liposomes prepared with the main lipids present in RBE4 cell membranes. Rhodamine 123 17-30 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 4-8 23589366-2 2013 The aim of present study was to test the hypothesis that the power balance between inhibition effects of RTV and induced activities of Pgp and CYP3A depends on the time after last RTV treatment (TimeR) in the chronic use of RTV; rhodamine 123 (Rho) and midazolam (MDZ) were administered at predetermined TimeR to rats pretreated with RTV for 7 days. Rhodamine 123 229-242 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 135-138 23589366-2 2013 The aim of present study was to test the hypothesis that the power balance between inhibition effects of RTV and induced activities of Pgp and CYP3A depends on the time after last RTV treatment (TimeR) in the chronic use of RTV; rhodamine 123 (Rho) and midazolam (MDZ) were administered at predetermined TimeR to rats pretreated with RTV for 7 days. Rhodamine 123 244-247 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 135-138 22652439-1 2012 Magnetic nanoparticles (NP) were developed for the active brain targeting of water-soluble P-glycoprotein (P-gp) substrate rhodamine 123 (Rh123). Rhodamine 123 138-143 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 91-105 22652439-1 2012 Magnetic nanoparticles (NP) were developed for the active brain targeting of water-soluble P-glycoprotein (P-gp) substrate rhodamine 123 (Rh123). Rhodamine 123 138-143 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 107-111 22799027-1 2012 An in vitro P-glycoprotein mediated drug biliary excretion model (B-Clear model) was developed and validated using sandwich-cultured rat hepatocytes (SCRH) and a model substrate rhodamine 123 (Rh123). Rhodamine 123 178-191 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 12-26 22799027-1 2012 An in vitro P-glycoprotein mediated drug biliary excretion model (B-Clear model) was developed and validated using sandwich-cultured rat hepatocytes (SCRH) and a model substrate rhodamine 123 (Rh123). Rhodamine 123 193-198 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 12-26 22579010-3 2012 Therefore, the purpose of this study was to investigate the effects of warm hepatic IR on the hepatobiliary disposition of rhodamine 123 (RH-123), a P-gp substrate, and its glucuronidated metabolite (RH-Glu), an Mrp2 substrate, in rats. Rhodamine 123 123-136 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 149-153 22263589-4 2012 Uptake of rhodamine 123 (Rho123), the typical P-gp substance, was measured with or without PCB. Rhodamine 123 10-23 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 46-50 22263589-4 2012 Uptake of rhodamine 123 (Rho123), the typical P-gp substance, was measured with or without PCB. Rhodamine 123 25-31 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 46-50 21198435-1 2011 Rhodamine 123 (RH-123) and its glucuronidated metabolite (RH-Glu) are excreted into the bile via the ABC efflux transporters P-glycoprotein (P-gp) and multidrug resistance-related protein type 2 (Mrp2), respectively. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 125-139 22127271-1 2011 Rhodamine 123 (R123), as a typical of P-gp substrate, was widely used to quantify P-glycoprotein (P-gp) functional efflux activity in vivo. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 38-42 22127271-1 2011 Rhodamine 123 (R123), as a typical of P-gp substrate, was widely used to quantify P-glycoprotein (P-gp) functional efflux activity in vivo. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 82-96 22127271-1 2011 Rhodamine 123 (R123), as a typical of P-gp substrate, was widely used to quantify P-glycoprotein (P-gp) functional efflux activity in vivo. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 98-102 22115032-5 2011 Finally, protein expression and activity of P-gp were confirmed by carrying out Western blot analysis and polarized transport of rhodamine-123 (Rho123) in rBMECs. Rhodamine 123 129-142 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 44-48 21198435-1 2011 Rhodamine 123 (RH-123) and its glucuronidated metabolite (RH-Glu) are excreted into the bile via the ABC efflux transporters P-glycoprotein (P-gp) and multidrug resistance-related protein type 2 (Mrp2), respectively. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 141-145 21198435-1 2011 Rhodamine 123 (RH-123) and its glucuronidated metabolite (RH-Glu) are excreted into the bile via the ABC efflux transporters P-glycoprotein (P-gp) and multidrug resistance-related protein type 2 (Mrp2), respectively. Rhodamine 123 15-21 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 125-139 21198435-1 2011 Rhodamine 123 (RH-123) and its glucuronidated metabolite (RH-Glu) are excreted into the bile via the ABC efflux transporters P-glycoprotein (P-gp) and multidrug resistance-related protein type 2 (Mrp2), respectively. Rhodamine 123 15-21 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 141-145 21198435-4 2011 Whereas SNP caused a substantial (85-90%) reduction in the P-gp- and Mrp2-mediated transport of RH-123 and RH-Glu, respectively, ISDN did not affect either of these transporters. Rhodamine 123 96-102 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 59-63 20870297-4 2011 Accumulation of P-glycoprotein (P-gp) substrate rhodamine 123 in normal or PAF injured RBMECs was measured with Poly Immune Analysis System-1420 to evaluate the function of P-gp on RBMECs. Rhodamine 123 48-61 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 16-30 20870297-4 2011 Accumulation of P-glycoprotein (P-gp) substrate rhodamine 123 in normal or PAF injured RBMECs was measured with Poly Immune Analysis System-1420 to evaluate the function of P-gp on RBMECs. Rhodamine 123 48-61 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 32-36 20950334-7 2010 In situ perfusion and in vitro experiments using a classical P-gp substrate rhodamine 123 linked the effect of nicotine to inhibition of BBB P-gp transport. Rhodamine 123 76-89 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 141-145 19881305-5 2009 The mucosal to serosal (absorptive) and serosal to mucosal (secretory) transport of rhodamine123 was significantly inhibited in the presence of 5.0-20% (v/v) of Wellsolve, suggesting that Wellsolve might not affect the function of P-gp in the intestine. Rhodamine 123 84-96 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 231-235 20108175-5 2010 P-GP function in the rat intestine was assessed by measuring the absorption of rhodamine 123 (Rho123). Rhodamine 123 79-92 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 20108175-5 2010 P-GP function in the rat intestine was assessed by measuring the absorption of rhodamine 123 (Rho123). Rhodamine 123 94-100 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 20233212-6 2010 In accord with behavioural observations, P-glycoprotein activity in brain was assessed using brain-to-plasma concentration ratios of rhodamine 123. Rhodamine 123 133-146 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 41-55 19499568-0 2010 Effects of P-glycoprotein and Mrp2 inhibitors on the hepatobiliary disposition of Rhodamine 123 and its glucuronidated metabolite in isolated perfused rat livers. Rhodamine 123 82-95 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 11-25 19499568-7 2010 It is concluded that the use of RH-123 in an IPRL model may serve as a dual marker for the determination of the altered functions of P-gp and/or Mrp2. Rhodamine 123 32-38 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 133-137 19814863-3 2009 METHODS: To evaluate the contribution of P-gp-mediated transport to the ileal excretion of rhodamine 123, we used Western blotting to measure the expression of P-gp protein levels isolated from the ileum at different reperfusion times after 60 min of ischaemia. Rhodamine 123 91-104 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 41-45 19814863-0 2009 Effect of intestinal ischaemia/reperfusion on P-glycoprotein-mediated ileal excretion of rhodamine 123 in the rat. Rhodamine 123 89-102 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 46-60 19814863-7 2009 These results suggest that intestinal ischaemia/reperfusion-induced decrease in P-gp-mediated ileal excretion of rhodamine 123 was probably due to impaired P-gp-mediated transport. Rhodamine 123 113-126 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 80-84 19814863-7 2009 These results suggest that intestinal ischaemia/reperfusion-induced decrease in P-gp-mediated ileal excretion of rhodamine 123 was probably due to impaired P-gp-mediated transport. Rhodamine 123 113-126 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 156-160 19814863-8 2009 Levels of P-gp protein and iNOS mRNA in the ileum decreased 3 h after ischaemia/reperfusion and returned to control levels after 24 h. CONCLUSIONS: These findings suggest that intestinal ischaemia/reperfusion markedly decreases P-gp-mediated ileal excretion of rhodamine 123, probably by decreasing the expression of P-gp protein, which is likely to be due to increased lipid peroxidation via iNOS. Rhodamine 123 261-274 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 10-14 17324141-15 2007 The in vivo function of P-gp was evaluated by measuring renal and biliary secretion of rhodamine-123 (Rho123) under a steady state plasma concentration. Rhodamine 123 87-100 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 24-28 19336907-3 2009 It also caused a significant increase of the P-glycoprotein and multidrug resistance associated protein 2 mediated effluxes through rat jejunum of marker substrates Rhodamine 123 and 2,4-dinitrophenyl-S-glutathione, respectively. Rhodamine 123 165-178 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 45-59 19881254-0 2009 Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat. Rhodamine 123 101-113 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 46-60 18082981-1 2008 The aim of this study was to evaluate the effects of docosahexaenoic acid (DHA) on the intestinal cytochrome P450 isoenzyme (CYP3A) and P-glycoprotein (P-gp) functions using midazolam and rhodamine-123 as specific substrates of CYP3A and P-gp, respectively. Rhodamine 123 188-201 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 152-156 17399699-7 2007 The activity of P-glycoprotein was evaluated by measuring the efflux of rhodamine-123 (Rho123) in rats using an in situ single perfusion method. Rhodamine 123 72-85 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 16-30 19726295-6 2009 CONCLUSION: Liquorice may slightly inhibit P-gp function in the intestinal mucosa to increase the intestinal absorption of rhodamine 123. Rhodamine 123 123-136 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 43-47 19505374-5 2009 P-glycoprotein expression at the blood-brain barrier was examined by Western blotting and RT-PCR, and its function was assessed by measuring the brain-to-plasma concentration ratios (Kp values) of rhodamine 123 (Rh123). Rhodamine 123 212-217 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-14 17845805-4 2007 P-GP expression and function were measured by Western blot analysis and rhodamine 123 (Rho 123) distribution in brain. Rhodamine 123 72-85 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 16500056-1 2006 We examined the effect of polyethylene glycols (PEGs) with different molecular weights and their derivatives on the intestinal absorption of rhodamine123, a P-glycoprotein (P-gp) substrate, across the isolated rat intestinal membranes by an in vitro diffusion chamber system. Rhodamine 123 141-153 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 157-171 17074306-2 2006 P-GP function in BBB was assessed by measuring the brain-to-plasma concentration ratios (Kp values) of rhodamine 123 (Rho123) and vincristine (VCR), two well-known P-GP substrates, in control rats and 5-week streptozotocin (STZ)-induced diabetic rats. Rhodamine 123 103-116 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 17074306-2 2006 P-GP function in BBB was assessed by measuring the brain-to-plasma concentration ratios (Kp values) of rhodamine 123 (Rho123) and vincristine (VCR), two well-known P-GP substrates, in control rats and 5-week streptozotocin (STZ)-induced diabetic rats. Rhodamine 123 118-124 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 16923159-6 2006 Application of 200 microm BSO caused a significant increase in Pgp function activity, as assessed by rhodamine 123 (Rh123) accumulation experiments. Rhodamine 123 101-114 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 63-66 16923159-6 2006 Application of 200 microm BSO caused a significant increase in Pgp function activity, as assessed by rhodamine 123 (Rh123) accumulation experiments. Rhodamine 123 116-121 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 63-66 16500056-1 2006 We examined the effect of polyethylene glycols (PEGs) with different molecular weights and their derivatives on the intestinal absorption of rhodamine123, a P-glycoprotein (P-gp) substrate, across the isolated rat intestinal membranes by an in vitro diffusion chamber system. Rhodamine 123 141-153 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 173-177 16124934-6 2005 Then, rhodamine 123 was used as a P-gp substrate and verapamil as an inhibitor. Rhodamine 123 6-19 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 34-38 16595917-0 2006 Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers. Rhodamine 123 44-57 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 62-76 16595917-0 2006 Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers. Rhodamine 123 44-57 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 78-81 16595917-0 2006 Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers. Rhodamine 123 44-57 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 120-123 16595917-2 2006 In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a marker for detecting the inducing effect of Pgp by drugs was identified, and the relationship between excretion clearances of Rho123 via Pgp and its expression during treatment with the representative Pgp inducers rifampicin (RFP), dexamethasone (DEX) and St. John"s Wort (SJW) were examined in rat liver, intestine and kidney. Rhodamine 123 45-58 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 132-135 16595917-2 2006 In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a marker for detecting the inducing effect of Pgp by drugs was identified, and the relationship between excretion clearances of Rho123 via Pgp and its expression during treatment with the representative Pgp inducers rifampicin (RFP), dexamethasone (DEX) and St. John"s Wort (SJW) were examined in rat liver, intestine and kidney. Rhodamine 123 60-66 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 132-135 16595917-2 2006 In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a marker for detecting the inducing effect of Pgp by drugs was identified, and the relationship between excretion clearances of Rho123 via Pgp and its expression during treatment with the representative Pgp inducers rifampicin (RFP), dexamethasone (DEX) and St. John"s Wort (SJW) were examined in rat liver, intestine and kidney. Rhodamine 123 214-220 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 225-228 16595917-2 2006 In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a marker for detecting the inducing effect of Pgp by drugs was identified, and the relationship between excretion clearances of Rho123 via Pgp and its expression during treatment with the representative Pgp inducers rifampicin (RFP), dexamethasone (DEX) and St. John"s Wort (SJW) were examined in rat liver, intestine and kidney. Rhodamine 123 214-220 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 225-228 16595917-7 2006 These observations suggest that the excretion clearances of Rho123 from blood circulation to the small intestine or to the bile after its intravenous administration are useful indicators to assess the Pgp function in the presence of Pgp inducers. Rhodamine 123 60-66 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 201-204 16595917-7 2006 These observations suggest that the excretion clearances of Rho123 from blood circulation to the small intestine or to the bile after its intravenous administration are useful indicators to assess the Pgp function in the presence of Pgp inducers. Rhodamine 123 60-66 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 233-236 15608134-2 2005 Rhodamine 123 was used as a model substrate for P-glycoprotein-mediated biliary excretion. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 48-62 15733228-0 2005 The effect of Mdr1 induction on the pharmacokinetics of rhodamine 123 in rats. Rhodamine 123 56-69 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 14-18 15234189-5 2004 Flow cytometry was used to study P-gp activity by analysis of intracellular rhodamine123 (Rh123) accumulation. Rhodamine 123 76-88 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 33-37 15689167-4 2005 By contrast, Taxol exposure substantially enhanced rhodamine 123 uptake by BMECs through inhibition of Pgp. Rhodamine 123 51-64 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 103-106 15638085-2 2004 The results showed that CsA combined with Ver or Tet synergistically inhibited P-gp mediated efflux of Rh123 from rat BMEC, suggesting that the combined application of P-gp inhibitors would possibly be a useful approach to increase drug concentration in brain tissues, enhance the therapeutic effect and reduce the toxicity of drugs. Rhodamine 123 103-108 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 79-83 15638085-2 2004 The results showed that CsA combined with Ver or Tet synergistically inhibited P-gp mediated efflux of Rh123 from rat BMEC, suggesting that the combined application of P-gp inhibitors would possibly be a useful approach to increase drug concentration in brain tissues, enhance the therapeutic effect and reduce the toxicity of drugs. Rhodamine 123 103-108 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 168-172 15663893-3 2005 The amount of intracellular rhodamine (Rh123) was determined, using a fluorescence spectrophotometer, to evaluate the function of P-gp. Rhodamine 123 39-44 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 130-134 15482640-5 2004 In rats treated with MPS, an in-situ efflux experiment using rhodamine-123 demonstrated that the reverse transport function of P-glycoprotein (P-gp) in the small intestine was significantly enhanced, although there was no significant increase in the intestinal microsomal activity of triazolam alpha- and 4-hydroxylation, metabolic probes for CYP3A. Rhodamine 123 61-74 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 127-141 15482640-5 2004 In rats treated with MPS, an in-situ efflux experiment using rhodamine-123 demonstrated that the reverse transport function of P-glycoprotein (P-gp) in the small intestine was significantly enhanced, although there was no significant increase in the intestinal microsomal activity of triazolam alpha- and 4-hydroxylation, metabolic probes for CYP3A. Rhodamine 123 61-74 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 143-147 15234189-5 2004 Flow cytometry was used to study P-gp activity by analysis of intracellular rhodamine123 (Rh123) accumulation. Rhodamine 123 90-95 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 33-37 15234189-6 2004 Overexpression of P-gp resulted in a decreased intracellular accumulation of Rh123 in RBMECs. Rhodamine 123 77-82 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 18-22 14999725-4 2004 The Jsm/Jms ratio of rhodamine123 decreased in the presence of 0.3 mM verapamil and 10 mM sodium azide (NaN3) + 1 mM sodium fluoride (NaF), confirming that rhodamine123 might be secreted from the intestinal tissue into the lumen by a P-gp-mediated efflux system. Rhodamine 123 156-168 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 234-238 14757850-3 2004 In addition, P-gp function in lymphocytes was assessed by measuring the ability of the P-gp inhibitor verapamil to limit the efflux of the fluorescent P-gp substrate rhodamine 123. Rhodamine 123 166-179 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 13-17 14757850-3 2004 In addition, P-gp function in lymphocytes was assessed by measuring the ability of the P-gp inhibitor verapamil to limit the efflux of the fluorescent P-gp substrate rhodamine 123. Rhodamine 123 166-179 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 87-91 14757850-3 2004 In addition, P-gp function in lymphocytes was assessed by measuring the ability of the P-gp inhibitor verapamil to limit the efflux of the fluorescent P-gp substrate rhodamine 123. Rhodamine 123 166-179 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 87-91 14999725-1 2004 Effects of various surfactants on the transport of rhodamine123, a P-glycoprotein (P-gp) substrate, across the isolated rat intestinal membranes were examined by an in vitro diffusion chamber system. Rhodamine 123 51-63 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 67-81 14999725-1 2004 Effects of various surfactants on the transport of rhodamine123, a P-glycoprotein (P-gp) substrate, across the isolated rat intestinal membranes were examined by an in vitro diffusion chamber system. Rhodamine 123 51-63 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 83-87 14999725-9 2004 of Cremophor EL is 0.0095 w/v%, interactions between rhodamine123 and the micellar form of Cremophor EL may decrease the P-gp-mediated efflux of rhodamine123 at higher concentrations. Rhodamine 123 53-65 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 121-125 14999725-9 2004 of Cremophor EL is 0.0095 w/v%, interactions between rhodamine123 and the micellar form of Cremophor EL may decrease the P-gp-mediated efflux of rhodamine123 at higher concentrations. Rhodamine 123 145-157 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 121-125 11709325-0 2001 Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 in rats. Rhodamine 123 78-91 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 23-37 12626638-1 2003 Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux transporter in the rat placental barrier. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 45-59 12626638-1 2003 Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux transporter in the rat placental barrier. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 61-65 12626638-1 2003 Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux transporter in the rat placental barrier. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 116-120 12626638-1 2003 Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux transporter in the rat placental barrier. Rhodamine 123 15-21 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 45-59 12626638-1 2003 Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux transporter in the rat placental barrier. Rhodamine 123 15-21 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 61-65 12626638-1 2003 Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux transporter in the rat placental barrier. Rhodamine 123 15-21 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 116-120 12235265-9 2002 Consistent with published reports, sirolimus was a good inhibitor of P-glycoprotein, inhibiting polarized basolateral-to-apical flux of rhodamine 123 with an IC(50) of 0.625 to 1.25 microM (cyclosporine caused >80% inhibition at 5 microM). Rhodamine 123 136-149 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 69-83 11870370-9 2002 Apart from this, structurally different COX inhibitors (indomethacin, meloxicam, NS-398) mediated significant inhibition of time-dependent and EGF-induced mdr1b mRNA overexpression, resulting in enhanced intracellular accumulation of the mdr1 substrate, rhodamine 123 (Rho123). Rhodamine 123 254-267 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 155-160 11870370-9 2002 Apart from this, structurally different COX inhibitors (indomethacin, meloxicam, NS-398) mediated significant inhibition of time-dependent and EGF-induced mdr1b mRNA overexpression, resulting in enhanced intracellular accumulation of the mdr1 substrate, rhodamine 123 (Rho123). Rhodamine 123 254-267 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 155-159 11709325-2 2001 The typical substrates for P glycoprotein, i.e., cyclosporine, colchicine, and erythromycin, inhibited the biliary clearance of rhodamine-123, whereas a substrate for organic cation transporter, cimetidine, did not inhibit clearance, suggesting that rhodamine-123 is transported mainly by P glycoprotein. Rhodamine 123 128-141 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 27-41 11709325-2 2001 The typical substrates for P glycoprotein, i.e., cyclosporine, colchicine, and erythromycin, inhibited the biliary clearance of rhodamine-123, whereas a substrate for organic cation transporter, cimetidine, did not inhibit clearance, suggesting that rhodamine-123 is transported mainly by P glycoprotein. Rhodamine 123 128-141 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 289-303 11709325-2 2001 The typical substrates for P glycoprotein, i.e., cyclosporine, colchicine, and erythromycin, inhibited the biliary clearance of rhodamine-123, whereas a substrate for organic cation transporter, cimetidine, did not inhibit clearance, suggesting that rhodamine-123 is transported mainly by P glycoprotein. Rhodamine 123 250-263 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 27-41 11709325-3 2001 The biliary, renal, and tubular secretory clearances of rhodamine-123 and the glomerular filtration rate significantly decreased 6 h after injection of endotoxin but returned to control levels by 24 h. These results suggest that endotoxin-induced decreases in P-glycoprotein-mediated biliary excretion and renal handling of rhodamine-123 were probably due to impairment of P-glycoprotein-mediated transport ability. Rhodamine 123 56-69 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 260-274 11709325-3 2001 The biliary, renal, and tubular secretory clearances of rhodamine-123 and the glomerular filtration rate significantly decreased 6 h after injection of endotoxin but returned to control levels by 24 h. These results suggest that endotoxin-induced decreases in P-glycoprotein-mediated biliary excretion and renal handling of rhodamine-123 were probably due to impairment of P-glycoprotein-mediated transport ability. Rhodamine 123 56-69 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 373-387 11709325-7 2001 The expression of Mdr1a mRNA in both liver and kidney decreased 6 h after endotoxin injection and returned to control levels after 24 h, whereas the expression of Mdr1b mRNA in liver increased at both times and that in kidney decreased at 24 h. These findings suggest that K. pneumoniae endotoxin dramatically decreases P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 probably by decreasing the expression of Mdr1a, which is likely due to increased plasma TNF-alpha levels. Rhodamine 123 375-388 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 163-168 9699503-7 1998 Moreover, intracellular steady-state levels of the mdr1 substrate rhodamine 123 were decreased in cells pretreated with TNF-alpha in comparison to controls, indicating an increase in functional transporter(s) mediating dye extrusion. Rhodamine 123 66-79 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 51-55 11560870-3 2001 The specific and fluorescent P-gp substrate rhodamine 123 (Rh123) and the P-gp substrate digoxin were selected as model compounds. Rhodamine 123 44-57 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 29-33 11560870-3 2001 The specific and fluorescent P-gp substrate rhodamine 123 (Rh123) and the P-gp substrate digoxin were selected as model compounds. Rhodamine 123 59-64 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 29-33 11477162-4 2001 After 5 weeks, intestinal transport of rhodamine 123, a P-glycoprotein substrate, was carried out using an in vitro model of everted gut sacs. Rhodamine 123 39-52 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 56-70 11445244-2 2001 The effect of EP 51389 on P-glycoprotein (P-gp) was evaluated by rhodamine 123 accumulation on monolayers of CH(R)C5 cells with increasing concentrations of EP 51389. Rhodamine 123 65-78 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 26-40 11445244-2 2001 The effect of EP 51389 on P-glycoprotein (P-gp) was evaluated by rhodamine 123 accumulation on monolayers of CH(R)C5 cells with increasing concentrations of EP 51389. Rhodamine 123 65-78 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 42-46 11159804-0 2001 Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone. Rhodamine 123 73-86 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 90-104 11137878-1 2001 Tissue plasminogen activator (0.01-30 microgram/ml) dose-dependently inhibited the functional activity of P-glycoprotein, assessed by rhodamine 123 accumulation in GP8 immortalized rat brain endothelial cells, but this effect was unrelated to its proteolytic activity. Rhodamine 123 134-147 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 106-120 10947958-5 2000 Accordingly, expression of mdr protein and extrusion of the mdr1 substrate rhodamine 123 were maximal under arterial pO(2) and reduced under venous pO(2). Rhodamine 123 75-88 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 60-64 11557129-0 2001 Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures. Rhodamine 123 89-102 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 14-18 11557129-0 2001 Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures. Rhodamine 123 89-102 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 74-78 11557129-2 2001 Rhodamine 123 (Rh123), a fluorescent dye which is accumulated by mitochondria, is a mdr1 substrate and a well-established tool to study mdr1 transport activity. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 84-88 11557129-2 2001 Rhodamine 123 (Rh123), a fluorescent dye which is accumulated by mitochondria, is a mdr1 substrate and a well-established tool to study mdr1 transport activity. Rhodamine 123 0-13 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 136-140 11557129-2 2001 Rhodamine 123 (Rh123), a fluorescent dye which is accumulated by mitochondria, is a mdr1 substrate and a well-established tool to study mdr1 transport activity. Rhodamine 123 15-20 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 84-88 11557129-2 2001 Rhodamine 123 (Rh123), a fluorescent dye which is accumulated by mitochondria, is a mdr1 substrate and a well-established tool to study mdr1 transport activity. Rhodamine 123 15-20 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 136-140 11557129-3 2001 Inhibitors of mdr1-dependent transport such as verapamil or cyclosporin A have been found to decrease Rh123 efflux from mdr1-expressing cells. Rhodamine 123 102-107 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 14-18 11557129-3 2001 Inhibitors of mdr1-dependent transport such as verapamil or cyclosporin A have been found to decrease Rh123 efflux from mdr1-expressing cells. Rhodamine 123 102-107 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 120-124 11557129-5 2001 In hepatocytes cultured for 4 days and expressing high levels of P-gp, intracellular Rh123 accumulation was enhanced in the presence of mdr1 inhibitors (cyclosporin A, 8 and 80 microM, verapamil, 8 and 80 microM, or triton X-100, 8 microM). Rhodamine 123 85-90 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 136-140 11557129-9 2001 These observations suggest that a hitherto unknown mechanism which is sensitive to modulators of mdr1-activity contributes to Rh123 uptake or accumulation in primary rat hepatocytes. Rhodamine 123 126-131 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 97-101 11428664-5 2001 The in-vivo P-glycoprotein function in these tissues was suppressed as evaluated by biliary and renal secretory clearances and brain distribution of rhodamine 123, a P-glycoprotein substrate. Rhodamine 123 149-162 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 12-26 11428664-5 2001 The in-vivo P-glycoprotein function in these tissues was suppressed as evaluated by biliary and renal secretory clearances and brain distribution of rhodamine 123, a P-glycoprotein substrate. Rhodamine 123 149-162 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 166-180 10494879-6 1999 Functional assays revealed that increasing drug resistance was paralleled by a decreased accumulation of rhodamine 123, a fluorescent dye which is a substrate of mdr1-mediated efflux activity. Rhodamine 123 105-118 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 162-166 10086998-0 1999 Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds. Rhodamine 123 13-26 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 30-44 10086998-1 1999 Effects of cytochrome P-450 3A- and P-glycoprotein (P-gp)-related compounds, erythromycin, midazolam, ketoconazole, verapamil, and quinidine, on transport of rhodamine 123 (Rho-123), a P-gp substrate, were studied in rat intestine and in Caco-2 cells. Rhodamine 123 158-171 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 36-50 10086998-1 1999 Effects of cytochrome P-450 3A- and P-glycoprotein (P-gp)-related compounds, erythromycin, midazolam, ketoconazole, verapamil, and quinidine, on transport of rhodamine 123 (Rho-123), a P-gp substrate, were studied in rat intestine and in Caco-2 cells. Rhodamine 123 173-180 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 36-50 10190554-10 1999 Intracellular steady-state levels of the mdrl substrate rhodamine 123, determined as parameter of mdr1-type transport activity, indicated that mdr1-dependent efflux was increased in hepatocytes pretreated with H2O2 or aminotriazole and decreased in antioxidant-treated cells. Rhodamine 123 56-69 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 98-102 10190554-10 1999 Intracellular steady-state levels of the mdrl substrate rhodamine 123, determined as parameter of mdr1-type transport activity, indicated that mdr1-dependent efflux was increased in hepatocytes pretreated with H2O2 or aminotriazole and decreased in antioxidant-treated cells. Rhodamine 123 56-69 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 143-147 9821664-0 1998 Renal excretion of rhodamine 123, a P-glycoprotein substrate, in rats with glycerol-induced acute renal failure. Rhodamine 123 19-32 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 36-50 9821664-1 1998 To clarify renal handling of rhodamine 123, a substrate for P-glycoprotein, in normal and diseased states, in-vivo clearance studies were performed with normal rats and rats with glycerol-induced acute renal failure. Rhodamine 123 29-42 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 60-74 9821664-3 1998 Co-administration of cyclosporin, a P-glycoprotein inhibitor, significantly reduced tubular secretion of rhodamine 123. Rhodamine 123 105-118 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 36-50 9821664-8 1998 These results imply that rhodamine 123 is secreted via P-glycoprotein in renal tubules and that the renal secretory clearance of rhodamine 123 was reduced after acute renal failure, probably because of impairment of P-glycoprotein. Rhodamine 123 25-38 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 55-69