PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23285492-0	2004	(11)C-Labeled rhodamine-123 The P-glycoprotein (P-gp; also known as MDR1 or ABCB1) is a member of the ATP-binding cassette transporter family of proteins (the multi-drug resistance (MDR) protein and the breast cancer resistance protein (BCRP) are the other two members of this group of proteins) that is responsible for the rapid transportation of drugs across the cell membrane (uptake and efflux) (1).	Rhodamine 123	14-27	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	68-72	
8638674-9	1996	The differential expression of mdr1 and mdr3 in mouse mesangial cell clones, the ability of mdr1 PGP to transport R-123, and the impairment of PGP-mediated transport in TKGM-F12 cells, coexpressing mdr1 and mdr3 products, are demonstrated.	Rhodamine 123	114-119	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	92-96	
30659321-5	2019	Analysis of fluorescent substrates export (flow cytometry) revealed that CRYO did not affect the efflux of fluorescein (MRP3, MRP4 and MRP5) but inhibited that of rhodamine 123 (MDR1) and calcein (MRP1 and MRP2).	Rhodamine 123	163-176	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	178-182	
30304236-7	2018	ABCB1 activity was evaluated via the rhodamine-123 transport and inhibited by cyclosporin A in hydrocortisone-treated and control mice.	Rhodamine 123	37-50	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	0-5	
26910071-6	2016	The use of ABCB1-transfected mouse T-lymphoma cell line to study the uptake/efflux of fluorescent probes like ethidium bromide (EB), rhodamine 123 (Rh-123), and carbocyanine dye DiOC2, in the presence and absence of potential inhibitors, is currently used in our laboratories to evaluate the ability of a drug to inhibit ABCB1-mediated drug accumulation and efflux.	Rhodamine 123	133-146	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	11-16	
26910071-6	2016	The use of ABCB1-transfected mouse T-lymphoma cell line to study the uptake/efflux of fluorescent probes like ethidium bromide (EB), rhodamine 123 (Rh-123), and carbocyanine dye DiOC2, in the presence and absence of potential inhibitors, is currently used in our laboratories to evaluate the ability of a drug to inhibit ABCB1-mediated drug accumulation and efflux.	Rhodamine 123	148-154	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	11-16	
26910071-7	2016	Here we describe and compare three in vitro methods, which evaluate the permeability, transport kinetics of fluorescent substrates, and inhibition of the ABCB1 efflux pump by drugs of chemical synthesis or extracted from natural sources, using model cancer cell lines overexpressing this transporter, namely (1) real-time fluorimetry that assesses the accumulation of ethidium bromide, (2) flow cytometry, and (3) fluorescent microscopy using rhodamine 123 and DiOC2.	Rhodamine 123	443-456	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	154-159	
25915534-6	2015	Mechanistically, trametinib potently blocked the drug-efflux activity of ABCB1 to increase the intracellular accumulation of rhodamine 123 and doxorubicin and stimulates the ATPase of ABCB1 without alteration of the expression of ABCB1.	Rhodamine 123	125-138	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	73-78	
8638674-9	1996	The differential expression of mdr1 and mdr3 in mouse mesangial cell clones, the ability of mdr1 PGP to transport R-123, and the impairment of PGP-mediated transport in TKGM-F12 cells, coexpressing mdr1 and mdr3 products, are demonstrated.	Rhodamine 123	114-119	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	92-96	
30396935-4	2018	Modulation of ABCB1 activity was measured by rhodamine 123 accumulation assay using flow cytometry.	Rhodamine 123	45-58	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	14-19	
24549231-6	2014	Some of the investigated compounds inhibited the ABCB1 transporter and caused rhodamine-123 accumulation in murine lymphoma cells transfected by human MDR1 gene, expressing the efflux pump (L5178).	Rhodamine 123	78-91	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	49-54	
24292587-3	2013	The modulation of ABCB1 transporter activity was studied by rhodamine123 accumulation, the apoptosis-inducing effect was investigated using fluorescein isothiocyanate (FITC)-labeled annexin V and propidium iodide.	Rhodamine 123	60-72	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	18-23	
23285492-0	2004	(11)C-Labeled rhodamine-123 The P-glycoprotein (P-gp; also known as MDR1 or ABCB1) is a member of the ATP-binding cassette transporter family of proteins (the multi-drug resistance (MDR) protein and the breast cancer resistance protein (BCRP) are the other two members of this group of proteins) that is responsible for the rapid transportation of drugs across the cell membrane (uptake and efflux) (1).	Rhodamine 123	14-27	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	76-81	
23285492-8	2004	Rhodamine-123 is a fluorescent dye that is used to measure the expression of P-gp in drug-resistant cells, and the National Cancer Institute of the United States uses it to screen for drugs that serve as substrates for MDR1 (6).	Rhodamine 123	0-13	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	219-223	
16101136-5	2005	The reversion of MDR was investigated by using a standard functional assay with rhodamine 123 as a fluorescent substrate analogue of doxorubicin.	Rhodamine 123	80-93	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	17-20	
15161038-2	2004	Reversion of MDR was investigated using a standard functional assay with rhodamine 123 as a fluorescent substrate analogue.	Rhodamine 123	73-86	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	13-16