PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30688455-5 2019 A total of 7 of 17 flavonoid substrates stimulated the P-gp efflux of rhodamine 123, and most substrates increased P-gp expression in KB/MDR cells. Rhodamines 70-79 ATP binding cassette subfamily B member 1 Homo sapiens 55-59 32232949-9 2020 Hence, the rotationally symmetric architecture of P-gp, which determines duality in ATP binding and rhodamine 123 interaction, also forms the basis for the existence of two independently operating outer gates. Rhodamines 100-109 ATP binding cassette subfamily B member 1 Homo sapiens 50-54 31087712-4 2019 The activity of P-glycoprotein (P-gp), as one of the membrane transporters, was determined by the rhodamine 123 (Rho 123) assay. Rhodamines 98-107 ATP binding cassette subfamily B member 1 Homo sapiens 16-30 31087712-4 2019 The activity of P-glycoprotein (P-gp), as one of the membrane transporters, was determined by the rhodamine 123 (Rho 123) assay. Rhodamines 98-107 ATP binding cassette subfamily B member 1 Homo sapiens 32-36 29130339-5 2019 Mechanistically, Ethyl lucidenates A could increase the intracellular accumulation of vincristine in K562/A02 cells through inhibiting the P-glycoprotein mediated drug-transport activity by rhodamine accumulation assay and cell cycle analysis. Rhodamines 190-199 ATP binding cassette subfamily B member 1 Homo sapiens 139-153 30688455-5 2019 A total of 7 of 17 flavonoid substrates stimulated the P-gp efflux of rhodamine 123, and most substrates increased P-gp expression in KB/MDR cells. Rhodamines 70-79 ATP binding cassette subfamily B member 1 Homo sapiens 115-119 29725247-8 2018 Salmonella significantly decreased the efflux capabilities of P-gp, as based on the influx of Rhodamine 123 assay. Rhodamines 94-103 ATP binding cassette subfamily B member 1 Homo sapiens 62-66 29773368-6 2018 In addition, the multifunctional NPs increased the permeability of rhodamine 123 because the thiomer THL-fucoidan in the NPs inhibited P-glycoprotein. Rhodamines 67-76 ATP binding cassette subfamily B member 1 Homo sapiens 135-149 30538042-7 2019 Meanwhile, it was also increased the retention of P-gp substrates DOX and Rhodamine 123 (Rho-123) while did not affect the ATPase activity. Rhodamines 74-83 ATP binding cassette subfamily B member 1 Homo sapiens 50-54 29534440-5 2018 Additionally, all of them except ATx 3 (+), caused similar results when the accumulation of the P-gp fluorescent substrate was evaluated after pre-incubating cells with the test compounds for 24 h, significantly reducing the rhodamine 123 intracellular accumulation as a result of a significant increase in P-gp activity. Rhodamines 225-234 ATP binding cassette subfamily B member 1 Homo sapiens 96-100 29534440-5 2018 Additionally, all of them except ATx 3 (+), caused similar results when the accumulation of the P-gp fluorescent substrate was evaluated after pre-incubating cells with the test compounds for 24 h, significantly reducing the rhodamine 123 intracellular accumulation as a result of a significant increase in P-gp activity. Rhodamines 225-234 ATP binding cassette subfamily B member 1 Homo sapiens 307-311 29498663-6 2018 Furthermore, capsaicin and piperine increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrates rhodamine and calcein and inhibited their efflux from the MDR cell lines. Rhodamines 129-138 ATP binding cassette subfamily B member 1 Homo sapiens 96-110 29498663-6 2018 Furthermore, capsaicin and piperine increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrates rhodamine and calcein and inhibited their efflux from the MDR cell lines. Rhodamines 129-138 ATP binding cassette subfamily B member 1 Homo sapiens 112-116 29146563-7 2018 Km and Vmax of P-gp mediated basolateral-to-apical (B-A) flux of rhodamine 123 were estimated to 332+-124muM and 111+-16pmol cm-2 min-1 (n=3, total N=6), respectively. Rhodamines 65-74 ATP binding cassette subfamily B member 1 Homo sapiens 15-19 29282978-3 2018 The effective permeability of the typical P-gp substrate rhodamine 123 (R123) in colon was significantly increased from (1.69 +- 0.22) x 10-5 cm/s in the control group to (3.39 +- 0.417) x 10-5 cm/s (p < 0.01) in the 3.5 mM IP6 group. Rhodamines 57-66 ATP binding cassette subfamily B member 1 Homo sapiens 42-46 29291440-7 2018 Oxime and particularly oxime ether formation strongly increased their inhibitory activity on the efflux of rhodamine 123 by P-glycoprotein (P-gp), while the new ecdysteroid lactam did not interfere with the efflux function. Rhodamines 107-116 ATP binding cassette subfamily B member 1 Homo sapiens 124-138 29291440-7 2018 Oxime and particularly oxime ether formation strongly increased their inhibitory activity on the efflux of rhodamine 123 by P-glycoprotein (P-gp), while the new ecdysteroid lactam did not interfere with the efflux function. Rhodamines 107-116 ATP binding cassette subfamily B member 1 Homo sapiens 140-144 29128272-8 2018 LA treatment minimizes STX cytotoxicity, evaluated by trypan blue and MTT assay and both STX and STX-LA treatments were efficient to induce P-gp activity measured by rhodamine 123 dye extrusion. Rhodamines 166-175 ATP binding cassette subfamily B member 1 Homo sapiens 140-144 29541662-4 2018 Thus, we provide solubility data on two prototypical P-gp substrates, digoxin and rhodamine 123, representing P-gp substrates with a relatively low- and high-aqueous solubility, respectively. Rhodamines 82-91 ATP binding cassette subfamily B member 1 Homo sapiens 53-57 29541662-4 2018 Thus, we provide solubility data on two prototypical P-gp substrates, digoxin and rhodamine 123, representing P-gp substrates with a relatively low- and high-aqueous solubility, respectively. Rhodamines 82-91 ATP binding cassette subfamily B member 1 Homo sapiens 110-114 28405849-6 2017 However, accumulation of adriamycin and rhodamine 123 were increased which suggested the depression of P-gp activity. Rhodamines 40-49 ATP binding cassette subfamily B member 1 Homo sapiens 103-107 28132103-5 2017 The C1236T, G2677A/T, and C3435T SNPs were determined, and the functionality of P-gp was assessed by flow cytometry (Rhodamine efflux assay). Rhodamines 117-126 ATP binding cassette subfamily B member 1 Homo sapiens 80-84 28533092-9 2017 Similarly, the presence of DM did not alter the locations of other drug-binding sites since the thiol reactive forms of the substrates verapamil or rhodamine labeled the same sites in transmembrane segments 5 (I306C for verapamil) and 6 (F343C for rhodamine) whether P-gp was in native membranes or in detergent micelles. Rhodamines 148-157 ATP binding cassette subfamily B member 1 Homo sapiens 267-271 28303028-4 2017 Mechanistically, alectinib increased the intracellular accumulation of ABCB1/ABCG2 substrates such as doxorubicin (DOX) and Rhodamine 123 (Rho 123) by inhibiting the efflux function of the transporters in ABCB1- or ABCG2-overexpressing cells but not in their parental sensitive cells. Rhodamines 124-133 ATP binding cassette subfamily B member 1 Homo sapiens 71-76 27821506-3 2017 Here we identify a subset of memory CD4+ T cells capable of effluxing cellular toxins, including rhodamine (Rho), through the multidrug efflux protein MDR1 (also known as P-glycoprotein and ABCB1). Rhodamines 97-106 ATP binding cassette subfamily B member 1 Homo sapiens 151-155 27821506-3 2017 Here we identify a subset of memory CD4+ T cells capable of effluxing cellular toxins, including rhodamine (Rho), through the multidrug efflux protein MDR1 (also known as P-glycoprotein and ABCB1). Rhodamines 97-106 ATP binding cassette subfamily B member 1 Homo sapiens 190-195 27545217-8 2016 The reversal of MDR by AKBA was evident in an intracellular increase in Rhodamine (Rh123), indicating that the activity of P-glycoprotein (P-gp) was blocked. Rhodamines 72-81 ATP binding cassette subfamily B member 1 Homo sapiens 123-137 27678410-8 2017 R or racemic form of tolterodine and R-tamsulosin concentration-dependently increased P-gp protein expression; the latter also enhanced P-gp efflux function in a rhodamine-based efflux assay. Rhodamines 162-171 ATP binding cassette subfamily B member 1 Homo sapiens 136-140 27545217-8 2016 The reversal of MDR by AKBA was evident in an intracellular increase in Rhodamine (Rh123), indicating that the activity of P-glycoprotein (P-gp) was blocked. Rhodamines 72-81 ATP binding cassette subfamily B member 1 Homo sapiens 139-143 26810690-3 2016 Materials and methods In Caco-2 cell experiments, the effects of baicalin and baicalein on P-gp activity were investigated using a P-gp substrate, rhodamine 123 and non-substrate fluorescein Na, by determining their intracellular fluorescence accumulation, and their effects on P-gp expression were determined using flow cytometry. Rhodamines 147-156 ATP binding cassette subfamily B member 1 Homo sapiens 91-95 27060462-0 2016 Measurement of Rhodamine 123 in Three-Dimensional Organoids: A Novel Model for P-Glycoprotein Inhibitor Screening. Rhodamines 15-24 ATP binding cassette subfamily B member 1 Homo sapiens 79-93 27060462-3 2016 In this study, a rapid, sensitive and efficient method to measure rhodamine 123 (Rh123, P-gp substrate) in 3D organoids was developed to analyse P-gp-mediated drug transport. Rhodamines 66-75 ATP binding cassette subfamily B member 1 Homo sapiens 88-92 27060462-3 2016 In this study, a rapid, sensitive and efficient method to measure rhodamine 123 (Rh123, P-gp substrate) in 3D organoids was developed to analyse P-gp-mediated drug transport. Rhodamines 66-75 ATP binding cassette subfamily B member 1 Homo sapiens 145-149 27196753-3 2016 Mechanistically, osimertinib increased the intracellular accumulations of doxorubicin (DOX) and Rhodamine 123 (Rho 123) by inhibiting the efflux function of the transporters in ABCB1- or ABCG2-overexpressing cells but not in their parental sensitive cells. Rhodamines 96-105 ATP binding cassette subfamily B member 1 Homo sapiens 177-182 26968974-0 2016 Effects of Polyoxyethylene Alkyl Ethers on the Intestinal Transport and Absorption of Rhodamine 123: A P-glycoprotein Substrate by In Vitro and In Vivo Studies. Rhodamines 86-95 ATP binding cassette subfamily B member 1 Homo sapiens 103-117 27077878-4 2016 14/16 of these P-gp inhibitors were found to increase rhodamine 123 accumulation in P-gp-overexpressing MCF7R cells, thus allowing the determination of their P-gp inhibitory potential, i.e., their half maximal inhibitor concentration (IC50) value towards P-gp-mediated transport of the dye. Rhodamines 54-63 ATP binding cassette subfamily B member 1 Homo sapiens 15-19 27077878-4 2016 14/16 of these P-gp inhibitors were found to increase rhodamine 123 accumulation in P-gp-overexpressing MCF7R cells, thus allowing the determination of their P-gp inhibitory potential, i.e., their half maximal inhibitor concentration (IC50) value towards P-gp-mediated transport of the dye. Rhodamines 54-63 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 27077878-4 2016 14/16 of these P-gp inhibitors were found to increase rhodamine 123 accumulation in P-gp-overexpressing MCF7R cells, thus allowing the determination of their P-gp inhibitory potential, i.e., their half maximal inhibitor concentration (IC50) value towards P-gp-mediated transport of the dye. Rhodamines 54-63 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 27077878-4 2016 14/16 of these P-gp inhibitors were found to increase rhodamine 123 accumulation in P-gp-overexpressing MCF7R cells, thus allowing the determination of their P-gp inhibitory potential, i.e., their half maximal inhibitor concentration (IC50) value towards P-gp-mediated transport of the dye. Rhodamines 54-63 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 27001764-0 2016 Geographical Distribution of MDR1 Expression in Leishmania Isolates, from Greece and Cyprus, Measured by the Rhodamine-123 Efflux Potential of the Isolates, Using Flow Cytometry. Rhodamines 109-118 ATP binding cassette subfamily B member 1 Homo sapiens 29-33 26258802-6 2016 The enhancement ratios of Papp calculated from the ratio between Papp of rhodamine 123 in the presence of P-gp inhibitors and Papp of rhodamine 123 alone were 2.36, 2.09, and 1.84-fold in the presence of PAA-Cys-2MNA, PAA-Cys, and PAA, respectively. Rhodamines 73-82 ATP binding cassette subfamily B member 1 Homo sapiens 106-110 26288998-6 2016 The enhancement ratios of Papp calculated from the ratio between Papp of rhodamine 123 in the presence of P-gp inhibitors and Papp of rhodamine 123 alone were 2.36, 2.09, and 1.84-fold in the presence of PAA-Cys-2MNA, PAA-Cys, and PAA, respectively. Rhodamines 73-82 ATP binding cassette subfamily B member 1 Homo sapiens 106-110 26486517-7 2015 Pgp function was assessed by a rhodamine efflux assay and (99m)Tc-sestamibi scintigraphy. Rhodamines 31-40 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 26506420-4 2015 Furthermore, cetuximab markedly increased intracellular accumulation of doxorubicin (DOX) and rhodamine 123 (Rho 123) in ABCB1-overexpressing MDR cancer cells in a concentration-dependent manner. Rhodamines 94-103 ATP binding cassette subfamily B member 1 Homo sapiens 121-126 26350141-5 2015 Microarray and real-time PCR analysis showed that ABCB1 mRNA is upregulated in these cells, and P-glycoprotein (P-gp) expression as well as function were confirmed by immunoblot and rhodamine exclusion assays. Rhodamines 182-191 ATP binding cassette subfamily B member 1 Homo sapiens 50-55 25995342-3 2015 EXPERIMENTAL DESIGN: ABCB1 efflux activity was determined using a rhodamine efflux assay. Rhodamines 66-75 ATP binding cassette subfamily B member 1 Homo sapiens 21-26 26153782-8 2015 In five EBV-T-LPDs patients, P-gp function was detected by Rhodamine-123 efflux assay in these cells. Rhodamines 59-68 ATP binding cassette subfamily B member 1 Homo sapiens 29-33 26350141-5 2015 Microarray and real-time PCR analysis showed that ABCB1 mRNA is upregulated in these cells, and P-glycoprotein (P-gp) expression as well as function were confirmed by immunoblot and rhodamine exclusion assays. Rhodamines 182-191 ATP binding cassette subfamily B member 1 Homo sapiens 96-110 26350141-5 2015 Microarray and real-time PCR analysis showed that ABCB1 mRNA is upregulated in these cells, and P-glycoprotein (P-gp) expression as well as function were confirmed by immunoblot and rhodamine exclusion assays. Rhodamines 182-191 ATP binding cassette subfamily B member 1 Homo sapiens 112-116 25470220-4 2015 Compound 7 h also enhanced the effects of other MDR-related cytotoxic agents (paclitaxel, vinblastine, and daunorubicin), increased the accumulation of DOX and blocked P-gp-mediated rhodamine 123 efflux function in K562/A02 MDR cells. Rhodamines 182-191 ATP binding cassette subfamily B member 1 Homo sapiens 168-172 26295572-3 2015 The results showed that the rhodamine 123 (Rh123) accumulation, an indicator of P-gp activity, in Caco-2, KBv and RBMECs was increased by (-)CLA (1 or 5 mumol/L) at 8.2%-28.5%, but reduced by (+)CLA at 11.7%-25.9%, showing stereoselectivity in their regulation of P-gp activity. Rhodamines 28-37 ATP binding cassette subfamily B member 1 Homo sapiens 80-84 26295572-3 2015 The results showed that the rhodamine 123 (Rh123) accumulation, an indicator of P-gp activity, in Caco-2, KBv and RBMECs was increased by (-)CLA (1 or 5 mumol/L) at 8.2%-28.5%, but reduced by (+)CLA at 11.7%-25.9%, showing stereoselectivity in their regulation of P-gp activity. Rhodamines 28-37 ATP binding cassette subfamily B member 1 Homo sapiens 264-268 25829763-7 2015 Further, the ability of ES to inhibit multi drug resistant (MDR) transporters (ABC-B1 and ABC-G2) was determined by Rhodamine (Rho) and Mitoxantrone (MXR) efflux assays. Rhodamines 116-125 ATP binding cassette subfamily B member 1 Homo sapiens 79-85 25829763-7 2015 Further, the ability of ES to inhibit multi drug resistant (MDR) transporters (ABC-B1 and ABC-G2) was determined by Rhodamine (Rho) and Mitoxantrone (MXR) efflux assays. Rhodamines 116-119 ATP binding cassette subfamily B member 1 Homo sapiens 79-85 26219569-7 2015 Interestingly, all resistant cells showed the induction of P-gp at the protein and RNA levels, which was associated with an increased efflux of the P-gp substrate rhodamine 123 (Rho123). Rhodamines 163-172 ATP binding cassette subfamily B member 1 Homo sapiens 59-63 26219569-7 2015 Interestingly, all resistant cells showed the induction of P-gp at the protein and RNA levels, which was associated with an increased efflux of the P-gp substrate rhodamine 123 (Rho123). Rhodamines 163-172 ATP binding cassette subfamily B member 1 Homo sapiens 148-152 25857708-3 2015 Rhodamine derivatives are validated fluorescent probes for measurement of mitochondrial membrane potential and also Pgp function. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 116-119 25857708-4 2015 The aim of this study was to investigate whether 2"[(18)F]-fluoroethylrhodamine B ((18)FRB) a halogenated rhodamine derivative previously synthesized for PET assessment of myocardial perfusion preserved its Pgp substrate character. Rhodamines 70-79 ATP binding cassette subfamily B member 1 Homo sapiens 207-210 25857708-8 2015 Dissipation of the mitochondrial proton gradient by a proton ionophore CCCP decreased the accumulation of rhodamine 123 (R123) and (18)FRB into Pgp(-) cells. Rhodamines 106-115 ATP binding cassette subfamily B member 1 Homo sapiens 144-147 25676275-4 2015 The expression of P-gp was detected by cell immunofluorescense analysis and the activity of P-gp was evaluated by Rhodamine 123 efflux experiment. Rhodamines 114-123 ATP binding cassette subfamily B member 1 Homo sapiens 92-96 25445037-8 2015 Most DHPs, particularly compounds bearing 3-nitrophenyl (A2B2 and A3B2) and 4-nitrophenyl (A3B1 and A4B1) moieties at C4 significantly inhibited rhodamine 123 efflux at 5-25 microM, showing that the mechanism of MDR reversal by these agents is P-gp transporter modulation. Rhodamines 145-154 ATP binding cassette subfamily B member 1 Homo sapiens 244-248 25372840-9 2014 The intracellular level of ATP decreased 44%, 46% in the presence of 12.5.25 microM 3-Bromopyruvate, whereas the accumulation of rhodamine 123 and epirubicin (two typical P-glycoprotein substrates) in cells was significantly increased. Rhodamines 129-138 ATP binding cassette subfamily B member 1 Homo sapiens 171-185 26046259-8 2015 Methyl-G increased the intracellular concentration of a known Pgp substrate, Rhodamine 123 in SF-295 cells. Rhodamines 77-86 ATP binding cassette subfamily B member 1 Homo sapiens 62-65 24734954-5 2014 MDR-1 function was assessed by Rhodamine efflux in presence or absence of verapamil. Rhodamines 31-40 ATP binding cassette subfamily B member 1 Homo sapiens 0-5 23468132-8 2013 In addition, ABCB1 and ABCB4 mediated the efflux of rhodamine 123 and rhodamine 6G from nonraft membranes, which was not affected by taurocholate. Rhodamines 52-61 ATP binding cassette subfamily B member 1 Homo sapiens 13-18 24504599-1 2014 In this work, we investigated Greek Leishmania isolates (n = 70) for their individual MDR1-gene-related p-gp (belonging to the ABC-B subfamily of permeases) expression levels by means of flow cytometric analysis of Rhodamine 123 extrusion kinetics. Rhodamines 215-224 ATP binding cassette subfamily B member 1 Homo sapiens 86-90 23897240-4 2013 In everted intestinal sacs, AP inhibited serosal-mucosal transport of rhodamine 123 (R123), a prototypical P-gp substrate. Rhodamines 70-79 ATP binding cassette subfamily B member 1 Homo sapiens 107-111 25050613-0 2014 Synthesis and characterization of macromolecular rhodamine tethers and their interactions with P-glycoprotein. Rhodamines 49-58 ATP binding cassette subfamily B member 1 Homo sapiens 95-109 25050613-1 2014 Rhodamine dyes are well-known P-glycoprotein (P-gp) substrates that have played an important role in the detection of inhibitors and other substrates of P-gp, as well as in the understanding of P-gp function. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 30-44 25050613-1 2014 Rhodamine dyes are well-known P-glycoprotein (P-gp) substrates that have played an important role in the detection of inhibitors and other substrates of P-gp, as well as in the understanding of P-gp function. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 46-50 25050613-1 2014 Rhodamine dyes are well-known P-glycoprotein (P-gp) substrates that have played an important role in the detection of inhibitors and other substrates of P-gp, as well as in the understanding of P-gp function. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 153-157 25050613-1 2014 Rhodamine dyes are well-known P-glycoprotein (P-gp) substrates that have played an important role in the detection of inhibitors and other substrates of P-gp, as well as in the understanding of P-gp function. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 153-157 25050613-2 2014 Macromolecular conjugates of rhodamines could prove useful as tethers for further probing of P-gp structure and function. Rhodamines 29-39 ATP binding cassette subfamily B member 1 Homo sapiens 93-97 24704556-6 2014 Furthermore, it could also increase the retention of ABCB1 substrates doxorubicin and rhodamine 123 in HepG2/ADM and MCF-7/ADR cells. Rhodamines 86-95 ATP binding cassette subfamily B member 1 Homo sapiens 53-58 24621983-5 2014 The impact of the 1199G>A SNP on ABCB1 activity towards rhodamine (Rh123), doxorubicin, vinblastine, tacrolimus and cyclosporine A was assessed by accumulation, cytotoxicity and/or kinetic experiments. Rhodamines 59-68 ATP binding cassette subfamily B member 1 Homo sapiens 36-41 23618585-9 2013 After 30 minutes of efflux, rhodamine 123 fluorescence intensity was significantly lower in BIU-87/ADM cells (5.55 vs 51.45, p = 0.004) and co-cultured BIU-87 cells than in BIU-87 cells (14.22 vs 51.45, p <0.001), indicating that P-glycoprotein was functional. Rhodamines 28-37 ATP binding cassette subfamily B member 1 Homo sapiens 233-247 23743668-5 2013 METHODS: Rhodamine (Rh123) efflux was used to study ABCB1 activity, with or without the addition of the ABCB1 inhibitor verapamil. Rhodamines 9-18 ATP binding cassette subfamily B member 1 Homo sapiens 52-57 23524533-4 2013 P-gp expression was determined by western blot and activity determined by rhodamine efflux assay. Rhodamines 74-83 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 22900779-6 2012 The IC(50) values of (-)-THP and (+)-THP on rhodamine 123 (P-gp substrate) efflux were 48.6 and 20.0 microM, respectively, which showed obvious stereoselective difference. Rhodamines 44-53 ATP binding cassette subfamily B member 1 Homo sapiens 59-63 23216707-6 2013 Pgp activity was evaluated in PBMC using the Rhodamine 123 efflux assay. Rhodamines 45-54 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 22226881-6 2012 It also significantly increased intracellular accumulation (21-fold) of rhodamine 123 in HEK293 MDR1 cells. Rhodamines 72-81 ATP binding cassette subfamily B member 1 Homo sapiens 96-100 23183822-10 2012 Of note, miR-211- and pM-treated CSC demonstrated increased drug retention capacity, as observed by MDR1/P-gp mediated-Rhodamine 123 drug efflux activity assay. Rhodamines 119-128 ATP binding cassette subfamily B member 1 Homo sapiens 100-104 22420656-4 2012 METHODS: P-gp drug efflux activity was measured by an in-situ closed loop method with Rhodamine 123, a P-gp substrate. Rhodamines 86-95 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 22420656-4 2012 METHODS: P-gp drug efflux activity was measured by an in-situ closed loop method with Rhodamine 123, a P-gp substrate. Rhodamines 86-95 ATP binding cassette subfamily B member 1 Homo sapiens 103-107 22420656-7 2012 KEY FINDINGS: ETP and morphine significantly decreased the intestinal Rhodamine 123 efflux activity of P-gp. Rhodamines 70-79 ATP binding cassette subfamily B member 1 Homo sapiens 103-107 21763326-7 2011 KEY FINDINGS: MDR1 blockade by the specific inhibitor verapamil reduced the percentage of rhodamine 123(low) cells in LDCs (from 31.8+-6.3% to 11.8+-2.8%, p<0.02). Rhodamines 90-99 ATP binding cassette subfamily B member 1 Homo sapiens 14-18 21920352-1 2011 P-Glycoprotein (Pgp) inhibition by three sets of four isomers of N,N-bis(cyclohexanol)amine aryl esters was assessed on rhodamine 123 (R123) efflux in human MDR1-gene transfected mouse T-lymphoma L5178 cells and on Sf9 ATPase activity. Rhodamines 120-129 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 21920352-1 2011 P-Glycoprotein (Pgp) inhibition by three sets of four isomers of N,N-bis(cyclohexanol)amine aryl esters was assessed on rhodamine 123 (R123) efflux in human MDR1-gene transfected mouse T-lymphoma L5178 cells and on Sf9 ATPase activity. Rhodamines 120-129 ATP binding cassette subfamily B member 1 Homo sapiens 16-19 21851848-8 2011 Accumulation studies demonstrated 31-38% decrease in rhodamine 123 intracellular levels when LS-180 cells were treated with the investigated compounds as a result of P-gp induction. Rhodamines 53-62 ATP binding cassette subfamily B member 1 Homo sapiens 166-170 22212563-5 2012 Apatinib treatment markedly increased the intracellular accumulation of doxorubicin and rhodamine 123 in K562/ADR cells and the accumulation of rhodamine 123 in the primary leukemia blasts with ABCB1 overexpression. Rhodamines 144-153 ATP binding cassette subfamily B member 1 Homo sapiens 194-199 22470447-3 2012 Rhodamine 123, a member of the rhodamine family of flurone dyes, has been used to examine membrane transport by the ABCB1 gene product, MDR1. Rhodamines 31-40 ATP binding cassette subfamily B member 1 Homo sapiens 116-121 22470447-3 2012 Rhodamine 123, a member of the rhodamine family of flurone dyes, has been used to examine membrane transport by the ABCB1 gene product, MDR1. Rhodamines 31-40 ATP binding cassette subfamily B member 1 Homo sapiens 136-140 20857089-4 2011 Cytotoxicity of doxorubicin (0-100 muM) and paraquat (0-1,000 muM) was evaluated for a maximum period of 96 h. In doxorubicin-exposed cells, P-gp expression and transport activity were evaluated by flow cytometry, using a fluorescein isothiocyanate-conjugated antibody and the P-gp fluorescent subtract rhodamine 123, respectively. Rhodamines 303-312 ATP binding cassette subfamily B member 1 Homo sapiens 141-145 21452853-9 2011 Consistent with these results, FSBA blocked efflux of rhodamine 123 from P-gp-expressing cells. Rhodamines 54-63 ATP binding cassette subfamily B member 1 Homo sapiens 73-77 21289467-6 2011 The elevation of the oocyte Pgp level was associated with increased activity of rhodamine 6G efflux from the oocyte, and its efflux was suppressed by verapamil, an inhibitor of Pgp. Rhodamines 80-89 ATP binding cassette subfamily B member 1 Homo sapiens 28-31 21081657-8 2011 Tariquidar inhibited Pgp-mediated rhodamine efflux from CD56(+) cells and reduced (99m)Tc-sestamibi clearance from the liver. Rhodamines 34-43 ATP binding cassette subfamily B member 1 Homo sapiens 21-24 20460821-2 2010 KP018 from Ellipeiopsis cherrevensis and AT80 from Ancistrocladus tectorius increased both rhodamine 123, a typical P-gp substrate, and [(3)H]paclitaxel uptake in PR-HepG2 cells. Rhodamines 91-100 ATP binding cassette subfamily B member 1 Homo sapiens 116-120 20955791-8 2011 Changes in expression were confined mostly to MDR1 and CYP3A4: in LS180 cells, treatment for 3 days increased MDR1 and CYP3A4 but not MRP2 mRNA, and elevated P-gp and CYP3A4 protein expression that led to decreased cellular accumulation of [(3)H]digoxin and rhodamine 123, and enhanced testosterone 6beta-hydroxylase activity towards T2007, respectively. Rhodamines 258-267 ATP binding cassette subfamily B member 1 Homo sapiens 46-50 20121943-9 2010 Thus, P-glycoprotein appears to pump rhodamines from the cytoplasmic leaflet either to the outer leaflet or to the outer medium. Rhodamines 37-47 ATP binding cassette subfamily B member 1 Homo sapiens 6-20 19783150-3 2010 In addition to being lipophilic cations, like (99m)Tc-MIBI, rhodamine dyes are known to accumulate in the myocardium and are substrates for Pgp, the protein implicated in MDR1 multidrug resistance. Rhodamines 60-69 ATP binding cassette subfamily B member 1 Homo sapiens 171-175 19538007-0 2009 Liposome composition is important for retention of liposomal rhodamine in P-glycoprotein-overexpressing cancer cells. Rhodamines 61-70 ATP binding cassette subfamily B member 1 Homo sapiens 74-88 19947169-6 2009 The effects of guggulsterone on P-glycoprotein activity were evaluated by measuring rhodamine 123 (Rh123)-associated mean fluorescence intensity and P-glycoprotein expression on the basis of the flow cytometric technology, respectively. Rhodamines 84-93 ATP binding cassette subfamily B member 1 Homo sapiens 32-46 19684997-2 2009 Exposure to a known mammalian inhibitor (verapamil, 10 1M) and inducer (rhodamine 123, 3 1M) on the transport protein P-glycoprotein (Pgp) was investigated in the liver of the western mosquitofish and bluegill sunfish. Rhodamines 72-81 ATP binding cassette subfamily B member 1 Homo sapiens 118-132 19684997-2 2009 Exposure to a known mammalian inhibitor (verapamil, 10 1M) and inducer (rhodamine 123, 3 1M) on the transport protein P-glycoprotein (Pgp) was investigated in the liver of the western mosquitofish and bluegill sunfish. Rhodamines 72-81 ATP binding cassette subfamily B member 1 Homo sapiens 134-137 19576864-6 2009 Additional evidence was obtained from time-resolved in situ fluorescence spectroscopic monitoring of the Pgp efflux dynamics in transfected Caco-2 cells which yielded significantly reduced transporter efficiencies for the Pgp substrate Rhodamine 123. Rhodamines 236-245 ATP binding cassette subfamily B member 1 Homo sapiens 105-108 19576864-6 2009 Additional evidence was obtained from time-resolved in situ fluorescence spectroscopic monitoring of the Pgp efflux dynamics in transfected Caco-2 cells which yielded significantly reduced transporter efficiencies for the Pgp substrate Rhodamine 123. Rhodamines 236-245 ATP binding cassette subfamily B member 1 Homo sapiens 222-225 19538007-7 2009 Surface charge of liposomes did not affect the rhodamine retention, whereas the incorporation of cholesterol and polyethyleneglycol-attached lipids was effective in further increasing the rhodamine retention in MCF-7/Pgp cells. Rhodamines 188-197 ATP binding cassette subfamily B member 1 Homo sapiens 217-220 19538007-5 2009 Pgp-expression decreased the rhodamine retention in MCF-7 cells, suggesting that Pgp is functional. Rhodamines 29-38 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 19538007-5 2009 Pgp-expression decreased the rhodamine retention in MCF-7 cells, suggesting that Pgp is functional. Rhodamines 29-38 ATP binding cassette subfamily B member 1 Homo sapiens 81-84 19538007-6 2009 Liposome loading increased rhodamine retention in MCF-7/Pgp cells, but not in MCF-7/WT cells. Rhodamines 27-36 ATP binding cassette subfamily B member 1 Homo sapiens 56-59 19124148-5 2009 The inhibition of efflux activity was measured via the increased rhodamine uptake by mouse lymphoma cells transfected in human MDR1 gene and in human brain capillary endothelial cells. Rhodamines 65-74 ATP binding cassette subfamily B member 1 Homo sapiens 127-131 19564743-3 2009 P-gp function was measured using the verapamil-sensitive Rhodamine efflux. Rhodamines 57-66 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 19429419-3 2009 The change in the mRNA expression of MDR1 was accompanied by a change in the CsA-dependent intracellular accumulation of rhodamine 123. Rhodamines 121-130 ATP binding cassette subfamily B member 1 Homo sapiens 37-41 19402665-0 2009 Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 24-38 18799096-5 2008 P-gp-mediated transport activity of cells was detected by rhodamine 123 efflux assay. Rhodamines 58-67 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 19881253-5 2009 The uptake of [(3)H]paclitaxel and rhodamine 123 increased by verapamil, a P-gp inhibitor. Rhodamines 35-44 ATP binding cassette subfamily B member 1 Homo sapiens 75-79 20053600-2 2009 P-glycoprotein activity in lymphocytes was measured by the Rhodamine 123 efflux assay using flow cytometry, in the presence and absence of verapamil, a P-glycoprotein inhibitor. Rhodamines 59-68 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 18945821-4 2009 The designed agents were potent inhibitors of rhodamine 123 efflux in cultured cancer cell lines that display high levels of P-gp expression at the cell surface and in transfected cells expressing P-gp. Rhodamines 46-55 ATP binding cassette subfamily B member 1 Homo sapiens 125-129 18945821-4 2009 The designed agents were potent inhibitors of rhodamine 123 efflux in cultured cancer cell lines that display high levels of P-gp expression at the cell surface and in transfected cells expressing P-gp. Rhodamines 46-55 ATP binding cassette subfamily B member 1 Homo sapiens 197-201 18845169-7 2008 KB3-1 significantly enhanced the accumulation and retention of a P-gp substrate, rhodamine-123 in the P-gp-expressing MES-SA/DX5 uterine sarcoma cells but not in the P-gp-negative MES-SA cells at non-toxic concentrations of 1 microM and 3 microM. Rhodamines 81-90 ATP binding cassette subfamily B member 1 Homo sapiens 65-69 18845169-7 2008 KB3-1 significantly enhanced the accumulation and retention of a P-gp substrate, rhodamine-123 in the P-gp-expressing MES-SA/DX5 uterine sarcoma cells but not in the P-gp-negative MES-SA cells at non-toxic concentrations of 1 microM and 3 microM. Rhodamines 81-90 ATP binding cassette subfamily B member 1 Homo sapiens 102-106 18845169-7 2008 KB3-1 significantly enhanced the accumulation and retention of a P-gp substrate, rhodamine-123 in the P-gp-expressing MES-SA/DX5 uterine sarcoma cells but not in the P-gp-negative MES-SA cells at non-toxic concentrations of 1 microM and 3 microM. Rhodamines 81-90 ATP binding cassette subfamily B member 1 Homo sapiens 102-106 18234965-9 2008 Silencing the expression of the DNA binding subunit of NF-kappaB, p50, by small interfering RNA vector resulted in a decrease of MDR1 function by rhodamine 123 efflux assay in T167 cells exposed to 2 Gy. Rhodamines 146-155 ATP binding cassette subfamily B member 1 Homo sapiens 129-133 17941015-8 2008 The in vitro Rhodamine 123 efflux experiment using MDR KB(v200) cells revealed that when cells were pretreated with folate-attached and FG020326-loaded micelles, the P-glycoprotein (P-gp) drug efflux function was significantly inhibited. Rhodamines 13-22 ATP binding cassette subfamily B member 1 Homo sapiens 166-180 17647225-10 2008 Based on the rhodamine accumulation study, the increased cytotoxicity is possibly due to the P-gp inhibition by CPGS. Rhodamines 13-22 ATP binding cassette subfamily B member 1 Homo sapiens 93-97 18302483-4 2008 After 12 days, MDR1 expression was determined by the rhodamine efflux assay. Rhodamines 53-62 ATP binding cassette subfamily B member 1 Homo sapiens 15-19 18646325-5 2008 Flow cytometry was also used to determine the efflux activity associated with P-gp; with this process, refluxed fluorescent P-gp substrate, rhodamine 123 (Rho123), was determined by the subsequently identified P-gp-positive PBMC subset. Rhodamines 140-149 ATP binding cassette subfamily B member 1 Homo sapiens 78-82 18646325-5 2008 Flow cytometry was also used to determine the efflux activity associated with P-gp; with this process, refluxed fluorescent P-gp substrate, rhodamine 123 (Rho123), was determined by the subsequently identified P-gp-positive PBMC subset. Rhodamines 140-149 ATP binding cassette subfamily B member 1 Homo sapiens 124-128 18646325-5 2008 Flow cytometry was also used to determine the efflux activity associated with P-gp; with this process, refluxed fluorescent P-gp substrate, rhodamine 123 (Rho123), was determined by the subsequently identified P-gp-positive PBMC subset. Rhodamines 140-149 ATP binding cassette subfamily B member 1 Homo sapiens 124-128 18234154-5 2008 CBT-1 completely inhibited rhodamine 123 transport from Pgp-overexpressing cells at a concentration of 1muM. Rhodamines 27-36 ATP binding cassette subfamily B member 1 Homo sapiens 56-59 17912240-7 2007 In addition, ZD6474 increases the intracellular accumulation of the P-gp substrate, rhodamine-123, and ADR, by enhancing the uptake and/or decreasing the efflux of these compounds in resistant cells. Rhodamines 84-93 ATP binding cassette subfamily B member 1 Homo sapiens 68-72 17917278-9 2007 At doses of 100 and 200 microM, Cap inhibited the transport of rhodamine 123 by P-gp-mediated efflux in Caco-2 cells. Rhodamines 63-72 ATP binding cassette subfamily B member 1 Homo sapiens 80-84 17286965-5 2007 Furthermore, C-4 treatment significantly increases in intracellular accumulation of fluorescent P-gp substrate rhodamine 123, indicating that C-4 treatment leads to reversal of the MDR phenotype resulting from an increased accumulation of anticancer drugs by inhibiting drug efflux function of P-gp. Rhodamines 111-120 ATP binding cassette subfamily B member 1 Homo sapiens 96-100 17705442-13 2007 Inhibition of P-gp-mediated rhodamine efflux with AOT-alginate nanoparticles was confirmed in primary brain microvessel endothelial cells. Rhodamines 28-37 ATP binding cassette subfamily B member 1 Homo sapiens 14-18 16530756-11 2006 Rhodamine uptake after treatment with verapamil was significantly greater in D407 and MDCK-MDR1, indicating functional expression of P-gp in these two cell lines. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 86-95 17982279-6 2007 RESULTS: Addition of cobalamin to the cells led to an increase in MS activity, to a significant decrease in mdr-1 gene expression which is correlated to an increase in retention of the Pgp substrate Rhodamine 123. Rhodamines 199-208 ATP binding cassette subfamily B member 1 Homo sapiens 185-188 17727795-0 2007 Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells. Rhodamines 86-95 ATP binding cassette subfamily B member 1 Homo sapiens 52-66 17727795-0 2007 Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells. Rhodamines 86-95 ATP binding cassette subfamily B member 1 Homo sapiens 127-141 16996216-3 2006 Expression of ABCB1 mRNA and ABCB1 activity were examined in atorvastatin-treated and control cells and PBMCs using real-time PCR and Rhodamine 123 efflux assay. Rhodamines 134-143 ATP binding cassette subfamily B member 1 Homo sapiens 14-19 16530756-11 2006 Rhodamine uptake after treatment with verapamil was significantly greater in D407 and MDCK-MDR1, indicating functional expression of P-gp in these two cell lines. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 133-137 15331656-7 2005 Furthermore, it potently blocked P-glycoprotein-mediated rhodamine 123 efflux under serum-free conditions (EC(50), approximately 8 microM), however, with reduced activity at increased serum concentrations (EC(50) at 10% serum, approximately 35 microM). Rhodamines 57-66 ATP binding cassette subfamily B member 1 Homo sapiens 33-47 16491453-2 2006 Among the active lathyrane derivatives 1 - 3, compound 2 displayed the highest inhibition of rhodamine 123 efflux of human MDR1 gene transfected mouse lymphoma cells when compared to the untreated cells or the positive control verapamil. Rhodamines 93-102 ATP binding cassette subfamily B member 1 Homo sapiens 123-127 16229491-5 2005 By carrying out single and sequential dual fluorescence titrations of purified P-glycoprotein with the two substrates, we observed that bound LDS-751 interacted with bound rhodamine 123. Rhodamines 172-181 ATP binding cassette subfamily B member 1 Homo sapiens 79-93 15963852-5 2005 Cellular efflux of the PgP substates rhodamine and doxorubicin was abolished. Rhodamines 37-46 ATP binding cassette subfamily B member 1 Homo sapiens 23-26 16319528-6 2006 Compared KBv200/MDR1sh cells with KBv200 cells, resistance to vincristine and doxorubicin decreased from 62.4-fold to 10.5-fold and from 74.5-fold to 9.5-fold respectively, and intracellular doxorubicin accumulation enhanced from 0.30 +/- 0.08 nmoles/10(6) cells to 0.86 +/- 0.16 nmoles/10(6) cells, and the fluorescence intensity of intracellular Rhodamine 123 accumulation increased from 3.58 +/- 1.63/10(6) cells to 13.96 +/- 3.07/10(6) cells. Rhodamines 348-357 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 15796199-3 2005 The rhodamine 123 accumulation of the P-glycoprotein (P-gp)-expressing cells increased up to 46.4, while 2,7"-bis(2-carboxyethyl)-5(6)-carboxy-fluorescein acetoxymethyl ester (BCECF-AM) accumulation of the MRP-expressing cells increased up to 1.6, in fluorescence activity ratio (FAR). Rhodamines 4-13 ATP binding cassette subfamily B member 1 Homo sapiens 38-52 15796199-3 2005 The rhodamine 123 accumulation of the P-glycoprotein (P-gp)-expressing cells increased up to 46.4, while 2,7"-bis(2-carboxyethyl)-5(6)-carboxy-fluorescein acetoxymethyl ester (BCECF-AM) accumulation of the MRP-expressing cells increased up to 1.6, in fluorescence activity ratio (FAR). Rhodamines 4-13 ATP binding cassette subfamily B member 1 Homo sapiens 54-58 15351776-1 2004 Extracts of bitter melon, soybean, dokudami and welsh onion by 40% methanol increased the accumulation of rhodamine-123 by Caco-2 cells, suggesting that these extracts inhibited P-glycoprotein (P-gp). Rhodamines 106-115 ATP binding cassette subfamily B member 1 Homo sapiens 178-192 15547738-5 2004 MDR1 functional activity was performed by a rhodamine (Rhd)-123 efflux test with or without verapamil. Rhodamines 44-53 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 15547738-5 2004 MDR1 functional activity was performed by a rhodamine (Rhd)-123 efflux test with or without verapamil. Rhodamines 55-58 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 15351776-1 2004 Extracts of bitter melon, soybean, dokudami and welsh onion by 40% methanol increased the accumulation of rhodamine-123 by Caco-2 cells, suggesting that these extracts inhibited P-glycoprotein (P-gp). Rhodamines 106-115 ATP binding cassette subfamily B member 1 Homo sapiens 194-198 15161039-10 2004 The rhodamine uptake was increased in L5178/MDR1 and Colo320/MDR1-LRP, but not drug-sensitive human breast cancer MCF-7 and T47D, and L5178 mouse lymphoma parent cells in the presence of alis-409 and alis-421. Rhodamines 4-13 ATP binding cassette subfamily B member 1 Homo sapiens 44-48 15201669-2 2004 METHODS: P-gp activity was measured by rhodamine efflux in T-cell subsets from bronchoalveolar lavage (BAL) of five healthy volunteers and 27 lung allograft recipients. Rhodamines 39-48 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 15138133-6 2004 The rhodamine extrusion test showed that the percentage of positive cells in MDR(+) cells was significantly lower than that in MDR1(-) cells. Rhodamines 4-13 ATP binding cassette subfamily B member 1 Homo sapiens 127-131 15254709-8 2004 After NS-398 treatment, Western blotting showed reduced P-gp expression and a rhodamine 123 efflux assay demonstrated a significant decrease in P-gp activity. Rhodamines 78-87 ATP binding cassette subfamily B member 1 Homo sapiens 144-148 15138133-4 2004 P-gp functions were evaluated through the rhodamine extrusion test. Rhodamines 42-51 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 15022031-5 2004 As the function of Pgp might be altered in advanced age, we investigated in groups of fit and frail elderly subjects whether the efflux of the Pgp-probe rhodamine 123 from CD56(+) natural killer cells was age dependent and whether it was affected by the two SNPs. Rhodamines 153-162 ATP binding cassette subfamily B member 1 Homo sapiens 143-146 15161039-10 2004 The rhodamine uptake was increased in L5178/MDR1 and Colo320/MDR1-LRP, but not drug-sensitive human breast cancer MCF-7 and T47D, and L5178 mouse lymphoma parent cells in the presence of alis-409 and alis-421. Rhodamines 4-13 ATP binding cassette subfamily B member 1 Homo sapiens 61-65 12975485-6 2003 The rhodamine 123 efflux assay showed that the efflux of rhodamine 123 in K562/DXR cells, which overexpress human P-gp, could be blocked markedly by imatinib mesilate in a dose-dependent fashion. Rhodamines 4-13 ATP binding cassette subfamily B member 1 Homo sapiens 114-118 15040543-12 2004 Basal P-gp-mediated rhodamine efflux was 61.0 +/- 4.2%. Rhodamines 20-29 ATP binding cassette subfamily B member 1 Homo sapiens 6-10 15301426-8 2004 Imidazole derivatives significantly increased the Dox accumulation and inhibited P-gp function exhibited by the increase of Rhodamine accumulation in MDR cells. Rhodamines 124-133 ATP binding cassette subfamily B member 1 Homo sapiens 81-85 14522974-0 2003 Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites. Rhodamines 36-45 ATP binding cassette subfamily B member 1 Homo sapiens 75-89 14666249-4 2003 P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. Rhodamines 60-69 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 12975485-6 2003 The rhodamine 123 efflux assay showed that the efflux of rhodamine 123 in K562/DXR cells, which overexpress human P-gp, could be blocked markedly by imatinib mesilate in a dose-dependent fashion. Rhodamines 57-66 ATP binding cassette subfamily B member 1 Homo sapiens 114-118 14567628-9 2003 A good correlation between Papp and cLogD (pH 7.4) of the compounds tested was observed, except for 3-OMG, AGN 197075, and rhodamine 123, which are substrates of carrier-mediated transport systems such as P-gp and a glucose transporter (GLUT1). Rhodamines 123-132 ATP binding cassette subfamily B member 1 Homo sapiens 205-209 12091325-3 2002 In this study, we evaluated the capacity of 4,5-dibromorhodamine methyl ester (TH9402), a photosensitizer structurally similar to rhodamine, a dye transported by Pgp, and which becomes highly cytotoxic on activation with visible light to selectively deplete alloreactive T lymphocytes. Rhodamines 55-64 ATP binding cassette subfamily B member 1 Homo sapiens 162-165 12682648-0 2003 Age-related changes of P-glycoprotein-mediated rhodamine 123 efflux in normal human bone marrow hematopoietic stem cells. Rhodamines 47-56 ATP binding cassette subfamily B member 1 Homo sapiens 23-37 12542697-0 2003 New insights into the P-glycoprotein-mediated effluxes of rhodamines. Rhodamines 58-68 ATP binding cassette subfamily B member 1 Homo sapiens 22-36 12542697-8 2003 The kinetic parameter, ka = VM/km, which is a measure of the efficiency of the P-gp-mediated efflux of a substrate was similar for almost all the rhodamine analogues tested. Rhodamines 146-155 ATP binding cassette subfamily B member 1 Homo sapiens 79-83 12542697-10 2003 Our conclusion is that the compounds of these two classes of molecules, anthracyclines and rhodamines, are substrates of P-gp and that their pumping rates at limiting low substrate concentration are similar. Rhodamines 91-101 ATP binding cassette subfamily B member 1 Homo sapiens 121-125 12542697-11 2003 The findings presented here are the first to show quantitative information about the kinetic parameters for P-gp-mediated efflux of rhodamine analogues in intact cells. Rhodamines 132-141 ATP binding cassette subfamily B member 1 Homo sapiens 108-112 12432340-15 2002 Steady-state rhodamine accumulation was increased in the presence of compounds reported to block P-glycoprotein mediated rhodamine efflux. Rhodamines 13-22 ATP binding cassette subfamily B member 1 Homo sapiens 97-111 12432340-15 2002 Steady-state rhodamine accumulation was increased in the presence of compounds reported to block P-glycoprotein mediated rhodamine efflux. Rhodamines 121-130 ATP binding cassette subfamily B member 1 Homo sapiens 97-111 12373300-11 2002 In contrast to DiOC2, rhodamine 123 was not specifically effluxed by P-gp but also by MRP1. Rhodamines 22-31 ATP binding cassette subfamily B member 1 Homo sapiens 69-73 12195825-5 2002 After Caco-2 cells were treated with 100 IU mL-1 (6.1 ng mL-1) IL2 for 24 h, a significant diminution (21%) of P-gp transporter function was observed with rhodamine-123 substrate. Rhodamines 155-164 ATP binding cassette subfamily B member 1 Homo sapiens 111-115 11945073-10 2002 TSA accelerated and glucocorticoid blocked export of rhodamine 123, a molecule known to be exported by PGP. Rhodamines 53-62 ATP binding cassette subfamily B member 1 Homo sapiens 103-106 12126537-8 2002 Rhodamine-123 efflux test showed that the efflux-pump function of P-gp 12 hours after the trransfection was 19.20% in control group, 25.59% in GEM5Zf (+)- MDR1 group, and 35.02% in pT7TS-MDR1 group (all P < 0.01). Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 66-70 12126537-8 2002 Rhodamine-123 efflux test showed that the efflux-pump function of P-gp 12 hours after the trransfection was 19.20% in control group, 25.59% in GEM5Zf (+)- MDR1 group, and 35.02% in pT7TS-MDR1 group (all P < 0.01). Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 155-159 11994059-9 2002 In contrast, P-glycoprotein function was significantly decreased in CD56+ cells of the TT compared with the CC group (rhodamine fluorescence CC vs TT: 45.6+/-7.2% vs 61.1+/-12.3%, P<0.05; 95% CI on the difference 5.6, 25.5). Rhodamines 118-127 ATP binding cassette subfamily B member 1 Homo sapiens 13-27 11849198-12 2002 P-glycoprotein mediated drug efflux was determined as a function of rhodamine efflux in the absence and presence of ritonavir. Rhodamines 68-77 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 11849198-19 2002 Ritonavir (5 microm) inhibited P-glycoprotein mediated efflux in both groups producing greater intracellular accumulation of rhodamine. Rhodamines 125-134 ATP binding cassette subfamily B member 1 Homo sapiens 31-45 11587212-4 2001 P-gp and MRP activity varied strongly between the cases (rhodamine 123 efflux-blocking by PSC833: 5.4+/-7.7, and carboxyfluorescein efflux-blocking by MK-571: 4.3+/-6.7, n = 60). Rhodamines 57-66 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 11801536-3 2002 Previous studies have shown that pluripotent hematopoietic stem cells overexpress the multidrug-resistant transport (MDR1) gene and efflux rhodamine, a substrate for the MDR1 transporter. Rhodamines 139-148 ATP binding cassette subfamily B member 1 Homo sapiens 117-121 11801536-3 2002 Previous studies have shown that pluripotent hematopoietic stem cells overexpress the multidrug-resistant transport (MDR1) gene and efflux rhodamine, a substrate for the MDR1 transporter. Rhodamines 139-148 ATP binding cassette subfamily B member 1 Homo sapiens 170-174 11434506-10 2001 Subjects with CC genotype revealed a significantly lower rhodamine fluorescence (i.e. higher PGP function) compared to individuals with TT genotype (51.1 +/- 11.4% versus 67.5 +/- 9.5%, p < 0.01). Rhodamines 57-66 ATP binding cassette subfamily B member 1 Homo sapiens 93-96 11434506-13 2001 In summary, subjects being homozygous for C in position 3435 of the MDR1 gene have a more pronounced efflux of rhodamine from CD56+ natural killer cells and a higher MDR1 mRNA expression in leukocytes than subjects with the TT genotype. Rhodamines 111-120 ATP binding cassette subfamily B member 1 Homo sapiens 68-72 11434506-14 2001 Measurement of rhodamine efflux using flow-cytometry from peripheral blood cells allows assessment of genetically determined differences in P-glycoprotein function. Rhodamines 15-24 ATP binding cassette subfamily B member 1 Homo sapiens 140-154 11104578-11 2000 Finally, it is revealed that these novel taxanes have ability to inhibit the function of the P-gp efflux pump on the basis of the Rhodamine 123 assay. Rhodamines 130-139 ATP binding cassette subfamily B member 1 Homo sapiens 93-97 11237063-7 2001 With a functional rhodamine retention assay using the modulator PSC833, increased MDR1 activity was observed in the -7/7q- group as compared to the control group of patients (P = 0.05). Rhodamines 18-27 ATP binding cassette subfamily B member 1 Homo sapiens 82-86 11778227-4 2000 RESULTS: Transduction of mdr1 ribozyme to A549/R cells led to decrease in mdr1 mRNA and Pgp expression; increase in rhodamine accumulation. Rhodamines 116-125 ATP binding cassette subfamily B member 1 Homo sapiens 25-29 11129093-7 2000 P-gp activity was determined by flow cytometry with rhodamine 123 efflux. Rhodamines 52-61 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 11218898-3 2000 The positive rate and function of the mdr1 gene product P-glycoprotein (P-gp) in SKOV3/mdr1 cells after mdr1-ASON (250 micrograms/ml) treatment were determined by flow cytometry and rhodamine 123 efflux trial. Rhodamines 182-191 ATP binding cassette subfamily B member 1 Homo sapiens 38-42 11218898-3 2000 The positive rate and function of the mdr1 gene product P-glycoprotein (P-gp) in SKOV3/mdr1 cells after mdr1-ASON (250 micrograms/ml) treatment were determined by flow cytometry and rhodamine 123 efflux trial. Rhodamines 182-191 ATP binding cassette subfamily B member 1 Homo sapiens 56-70 11218898-3 2000 The positive rate and function of the mdr1 gene product P-glycoprotein (P-gp) in SKOV3/mdr1 cells after mdr1-ASON (250 micrograms/ml) treatment were determined by flow cytometry and rhodamine 123 efflux trial. Rhodamines 182-191 ATP binding cassette subfamily B member 1 Homo sapiens 72-76 11218898-6 2000 Intracellular rhodamine retension in SKOV3/mdr1 cells after mdr1-ASON treatment was increased from 32.1% to 50.7% (P < 0.01). Rhodamines 14-23 ATP binding cassette subfamily B member 1 Homo sapiens 43-47 11218898-6 2000 Intracellular rhodamine retension in SKOV3/mdr1 cells after mdr1-ASON treatment was increased from 32.1% to 50.7% (P < 0.01). Rhodamines 14-23 ATP binding cassette subfamily B member 1 Homo sapiens 60-64 9920827-9 1999 P-gp function was assessed in 19 patients using rhodamine-123 efflux and its inhibition by PSC. Rhodamines 48-57 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 10361105-5 1999 Pgp expression and function were analyzed by flow cytometric analysis of MRK 16 binding and Rhodamine 123 retention, respectively. Rhodamines 92-101 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 10585262-3 1999 These two agents inhibited the Pgp function (rhodamine-123 excretion) as well as cell-mediated cytotoxicity, confirming that Pgp is critical for NK cell-mediated cytotoxicity. Rhodamines 45-54 ATP binding cassette subfamily B member 1 Homo sapiens 125-128 10379790-10 1999 Rhodamine efflux correlated with MDR-1 mRNA expression (r = 0.87) and with the IC50s (r = 0.60) for paclitaxel in the paired cell lines. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 33-38 10195430-3 1999 Functional expression of Cmdr1 in both mouse NIH 3T3 and yeast cells demonstrated that Cmdr1 represents the avian ortholog of human Mdr1, since it confers resistance to several anticancer drugs and the fluorescent dye rhodamine 6G. Rhodamines 218-227 ATP binding cassette subfamily B member 1 Homo sapiens 132-136 9920827-10 1999 The median percentage of blasts expressing P-gp was increased (49%) for leukemic cells with PSC-inhibitable rhodamine efflux compared with 17% in cases lacking PSC-inhibitable efflux (P =.004). Rhodamines 108-117 ATP binding cassette subfamily B member 1 Homo sapiens 43-47 9891078-5 1999 Using an approach involving exchanging homologous segments of MDR1 and MDR2 and site-directed mutagenesis, we have demonstrated that MDR1 residues Q330, V331, and L332 in transmembrane domain 6 are sufficient to allow an MDR2 backbone in the N-terminal half of P-gp to transport several MDR1 substrates, including bisantrene, colchicine, vinblastine, and rhodamine-123. Rhodamines 355-364 ATP binding cassette subfamily B member 1 Homo sapiens 62-66 9891078-5 1999 Using an approach involving exchanging homologous segments of MDR1 and MDR2 and site-directed mutagenesis, we have demonstrated that MDR1 residues Q330, V331, and L332 in transmembrane domain 6 are sufficient to allow an MDR2 backbone in the N-terminal half of P-gp to transport several MDR1 substrates, including bisantrene, colchicine, vinblastine, and rhodamine-123. Rhodamines 355-364 ATP binding cassette subfamily B member 1 Homo sapiens 133-137 9891078-5 1999 Using an approach involving exchanging homologous segments of MDR1 and MDR2 and site-directed mutagenesis, we have demonstrated that MDR1 residues Q330, V331, and L332 in transmembrane domain 6 are sufficient to allow an MDR2 backbone in the N-terminal half of P-gp to transport several MDR1 substrates, including bisantrene, colchicine, vinblastine, and rhodamine-123. Rhodamines 355-364 ATP binding cassette subfamily B member 1 Homo sapiens 261-265 9891078-5 1999 Using an approach involving exchanging homologous segments of MDR1 and MDR2 and site-directed mutagenesis, we have demonstrated that MDR1 residues Q330, V331, and L332 in transmembrane domain 6 are sufficient to allow an MDR2 backbone in the N-terminal half of P-gp to transport several MDR1 substrates, including bisantrene, colchicine, vinblastine, and rhodamine-123. Rhodamines 355-364 ATP binding cassette subfamily B member 1 Homo sapiens 133-137 9687882-5 1998 In resistant cells, MDR is characterized by overexpression of P-gp and by the enhanced efflux, and P-gp fluorescence probe, rhodamine 123 (Rh 123). Rhodamines 124-133 ATP binding cassette subfamily B member 1 Homo sapiens 99-103 9864175-0 1999 Efflux of rhodamine from CD56+ cells as a surrogate marker for reversal of P-glycoprotein-mediated drug efflux by PSC 833. Rhodamines 10-19 ATP binding cassette subfamily B member 1 Homo sapiens 75-89 9864175-9 1999 We conclude that measurement of rhodamine efflux from CD56(+) cells provides a surrogate assay with the potential for monitoring Pgp antagonism in clinical trials. Rhodamines 32-41 ATP binding cassette subfamily B member 1 Homo sapiens 129-132 9436932-3 1997 P-gp expression in the myeloma cells was determined using monoclonal antibody 4E3.16 and the rhodamine 123 functional test. Rhodamines 93-102 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 9393602-4 1997 Pgp status was determined by using monoclonal antibodies JSB-1 and MRK-16 and by assessment of rhodamine efflux. Rhodamines 95-104 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 9311609-9 1997 Rhodamine efflux data, indicated by PGP overexpression, underlined the development of this MDR mechanism in the newly established breast carcinoma lines MT-1/ADR, MT-3/ADR and MaTu/ADR. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 36-39 9038218-7 1997 The mutant P-glycoprotein has a decreased affinity for PSC 833 and vinblastine and a decreased ability to transport rhodamine 123. Rhodamines 116-125 ATP binding cassette subfamily B member 1 Homo sapiens 11-25 9310367-0 1997 Efficiency of P-glycoprotein-mediated exclusion of rhodamine dyes from multidrug-resistant cells is determined by their passive transmembrane movement rate. Rhodamines 51-60 ATP binding cassette subfamily B member 1 Homo sapiens 14-28 9310367-2 1997 For this purpose, seven rhodamine dyes were examined for their P-glycoprotein-mediated exclusion from MDR cells, their localization in wild-type drug-sensitive cells, their capacity to stimulate the ATPase activity of P-glycoprotein reconstituted in proteoliposomes, and their transmembrane movement rate in artificial liposomes. Rhodamines 24-33 ATP binding cassette subfamily B member 1 Homo sapiens 218-232 9310367-5 1997 The transmembrane movement rate proved the major factor determining the efficacy of the P-glycoprotein-mediated exclusion of rhodamine dyes from MDR cells. Rhodamines 125-134 ATP binding cassette subfamily B member 1 Homo sapiens 88-102 9322679-5 1997 P-gp activity was defined as a ratio of mean rhodamine 123 accumulation with/without verapamil. Rhodamines 45-54 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 9205006-4 1997 We have focused our efforts of P-gp detection on flow cytometry using a dual technique of P-gp staining with antibodies for the extracellular epitope (MRK16) and a functional analysis of P-gp using the rhodamine efflux assay and the effect of P-gp inhibitors such as SDZ PSC 833. Rhodamines 202-211 ATP binding cassette subfamily B member 1 Homo sapiens 31-35 9108417-8 1997 Multidrug resistance investigations suggest that agressive clinical findings could be related to MDR1 gene expression as confirmed by MDR1 mRNA detection, MDR1 gene product (Pgp) expression, and a functional multidrug resistance study using rhodamine efflux by flow-cytometry. Rhodamines 241-250 ATP binding cassette subfamily B member 1 Homo sapiens 97-101 8913319-3 1996 However, accumulation of daunorubicin and rhodamine 123 was > 85% reduced in the P-glycoprotein-expressing subline compared to 40-50% in the MRP-expressing subline. Rhodamines 42-51 ATP binding cassette subfamily B member 1 Homo sapiens 84-98 9350197-9 1997 A reliable way to measure Pgp seems to be the assessment of the active transport of fluorescent Pgp substrates, such as rhodamine 123 out of AML cells. Rhodamines 120-129 ATP binding cassette subfamily B member 1 Homo sapiens 26-29 9350197-9 1997 A reliable way to measure Pgp seems to be the assessment of the active transport of fluorescent Pgp substrates, such as rhodamine 123 out of AML cells. Rhodamines 120-129 ATP binding cassette subfamily B member 1 Homo sapiens 96-99 8695847-4 1996 The efflux of Rh123 could be inhibited by verapamil, suggesting that rhodamine efflux from primitive hematopoietic cells is primarily due to the P-glycoprotein (P-gp) pump or another intracellular transport system affected by verapamil. Rhodamines 69-78 ATP binding cassette subfamily B member 1 Homo sapiens 145-159 8695847-4 1996 The efflux of Rh123 could be inhibited by verapamil, suggesting that rhodamine efflux from primitive hematopoietic cells is primarily due to the P-glycoprotein (P-gp) pump or another intracellular transport system affected by verapamil. Rhodamines 69-78 ATP binding cassette subfamily B member 1 Homo sapiens 161-165 7795216-10 1995 P-glycoprotein function in host marrow was confirmed by rhodamine-123 efflux. Rhodamines 56-65 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 8624264-8 1996 Staurosporine and CGP 41251 at 10 and 20 nM, respectively, decreased efflux of the P-gp probe rhodamine 123 (R123) from MCF-7/Adr cells, whereas RO 31 8220 and GF 109203X at 640 nM were inactive. Rhodamines 94-103 ATP binding cassette subfamily B member 1 Homo sapiens 83-87 7564516-3 1995 P-gp function was measured by rhodamine 123 (Rh 123) efflux kinetics. Rhodamines 30-39 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 7669666-1 1995 The MDR1 gene product P-glycoprotein (P-gp) extrudes several anticancer drugs including taxol and fluorescent dyes such as rhodamine (Rh123). Rhodamines 123-132 ATP binding cassette subfamily B member 1 Homo sapiens 4-8 7669666-1 1995 The MDR1 gene product P-glycoprotein (P-gp) extrudes several anticancer drugs including taxol and fluorescent dyes such as rhodamine (Rh123). Rhodamines 123-132 ATP binding cassette subfamily B member 1 Homo sapiens 22-36 7669666-1 1995 The MDR1 gene product P-glycoprotein (P-gp) extrudes several anticancer drugs including taxol and fluorescent dyes such as rhodamine (Rh123). Rhodamines 123-132 ATP binding cassette subfamily B member 1 Homo sapiens 38-42 8668925-3 1996 Rhodamine 123 dye efflux measures P-glycoprotein activity and inhibition of P-glycoprotein results in dye retention. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 34-48 8668925-3 1996 Rhodamine 123 dye efflux measures P-glycoprotein activity and inhibition of P-glycoprotein results in dye retention. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 76-90 8562416-4 1996 Pgp functional activity was investigated by evaluation of verapamil influence upon rhodamine 123 efflux from the cells. Rhodamines 83-92 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 7733620-0 1995 Rhodamine 123: is it an appropriate dye to study P-glycoprotein activity in adriamycin-resistant K562 cells? Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 49-63 7559918-7 1995 In contrast, CsA and PSC were more potent as inhibitors of P-gp-mediated rhodamine 123 dye efflux than the verapamil isomers. Rhodamines 73-82 ATP binding cassette subfamily B member 1 Homo sapiens 59-63 7552989-6 1995 Rhodamine efflux studies showed that this additional p-glycoprotein was functional and that the frequency of cells with high p-glycoprotein levels was higher in the transduced cells than in the non-transduced cells. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 53-67 7552989-6 1995 Rhodamine efflux studies showed that this additional p-glycoprotein was functional and that the frequency of cells with high p-glycoprotein levels was higher in the transduced cells than in the non-transduced cells. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 125-139 7643452-2 1995 Functional P-gp expression was examined by Rhodamine-123 efflux test, and estimated with the data by RT-PCR method. Rhodamines 43-52 ATP binding cassette subfamily B member 1 Homo sapiens 11-15 7733620-5 1995 Thus, in adriamycin-resistant K562 cells, the rhodamine efflux may be due to P-glycoprotein activity and also to a nonspecific targeting of dye in resistant K562 cells. Rhodamines 46-55 ATP binding cassette subfamily B member 1 Homo sapiens 77-91 7872688-7 1994 It was concluded that MRK16 and rhodamine 123 were well adapted to detect P-gp and evaluate its functional ability. Rhodamines 32-41 ATP binding cassette subfamily B member 1 Homo sapiens 74-78 7727866-6 1994 The detection of functional GP170 can be identified by rhodamine or daunorubicin intracellular accumulation with flux cytometry or by scintigraphically imaging GP170 expression in vivo with Tc-Sestamibi. Rhodamines 55-64 ATP binding cassette subfamily B member 1 Homo sapiens 28-33 7980629-4 1994 P-glycoprotein was functional in terms of rhodamine dye excretion and its susceptibility to the MDR-reversing agents. Rhodamines 42-51 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 7513198-8 1994 P-gly function was determined for each lineage using dual-labeling for lineage and P-gly substrate (rhodamine 123). Rhodamines 100-109 ATP binding cassette subfamily B member 1 Homo sapiens 0-5 7969041-0 1994 Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 34-48 7969041-4 1994 There was a significant correlation between mdr-1 expression and rhodamine efflux in the 58 cell lines (r = 0.788, p = 0.0001). Rhodamines 65-74 ATP binding cassette subfamily B member 1 Homo sapiens 44-49 7513198-8 1994 P-gly function was determined for each lineage using dual-labeling for lineage and P-gly substrate (rhodamine 123). Rhodamines 100-109 ATP binding cassette subfamily B member 1 Homo sapiens 83-88 7513198-13 1994 We conclude that (1) P-gly and the MDR1 mRNA are expressed in normal leukocytes, (2) this P-gly expression is lineage specific with relatively high levels among CD56+ cells, and (3) the expression of P-gly in granulocytes is not associated with transport of the P-gly substrate, rhodamine 123, out of the cell. Rhodamines 279-288 ATP binding cassette subfamily B member 1 Homo sapiens 21-26 7513198-13 1994 We conclude that (1) P-gly and the MDR1 mRNA are expressed in normal leukocytes, (2) this P-gly expression is lineage specific with relatively high levels among CD56+ cells, and (3) the expression of P-gly in granulocytes is not associated with transport of the P-gly substrate, rhodamine 123, out of the cell. Rhodamines 279-288 ATP binding cassette subfamily B member 1 Homo sapiens 35-39 7513198-13 1994 We conclude that (1) P-gly and the MDR1 mRNA are expressed in normal leukocytes, (2) this P-gly expression is lineage specific with relatively high levels among CD56+ cells, and (3) the expression of P-gly in granulocytes is not associated with transport of the P-gly substrate, rhodamine 123, out of the cell. Rhodamines 279-288 ATP binding cassette subfamily B member 1 Homo sapiens 90-95 7513198-13 1994 We conclude that (1) P-gly and the MDR1 mRNA are expressed in normal leukocytes, (2) this P-gly expression is lineage specific with relatively high levels among CD56+ cells, and (3) the expression of P-gly in granulocytes is not associated with transport of the P-gly substrate, rhodamine 123, out of the cell. Rhodamines 279-288 ATP binding cassette subfamily B member 1 Homo sapiens 90-95 7513198-13 1994 We conclude that (1) P-gly and the MDR1 mRNA are expressed in normal leukocytes, (2) this P-gly expression is lineage specific with relatively high levels among CD56+ cells, and (3) the expression of P-gly in granulocytes is not associated with transport of the P-gly substrate, rhodamine 123, out of the cell. Rhodamines 279-288 ATP binding cassette subfamily B member 1 Homo sapiens 90-95 7690250-5 1993 Impaired transport of rhodamine in normal T lymphocytes treated with staurosporine demonstrates that modulation of P-glycoprotein function is not limited to cells selected for drug resistance in vitro. Rhodamines 22-31 ATP binding cassette subfamily B member 1 Homo sapiens 115-129 7910786-4 1994 P-gp-mediated rhodamine 123 efflux from dye-loaded single-cell suspensions of HCT-8 cells as measured by flow cytometry was not impeded at pHo 6.8 in comparison with pHo 7.5 in standard medium, but at low pHo the inhibitory activity of R-VPL (29% vs 60% rhodamine 123 efflux inhibition) was diminished significantly, again without a reduction in the effect of PSC 833 (rhodamine 123 flux inhibition, 75%). Rhodamines 14-23 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 7910786-4 1994 P-gp-mediated rhodamine 123 efflux from dye-loaded single-cell suspensions of HCT-8 cells as measured by flow cytometry was not impeded at pHo 6.8 in comparison with pHo 7.5 in standard medium, but at low pHo the inhibitory activity of R-VPL (29% vs 60% rhodamine 123 efflux inhibition) was diminished significantly, again without a reduction in the effect of PSC 833 (rhodamine 123 flux inhibition, 75%). Rhodamines 254-263 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 7910786-4 1994 P-gp-mediated rhodamine 123 efflux from dye-loaded single-cell suspensions of HCT-8 cells as measured by flow cytometry was not impeded at pHo 6.8 in comparison with pHo 7.5 in standard medium, but at low pHo the inhibitory activity of R-VPL (29% vs 60% rhodamine 123 efflux inhibition) was diminished significantly, again without a reduction in the effect of PSC 833 (rhodamine 123 flux inhibition, 75%). Rhodamines 254-263 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 7694687-2 1993 The results of MDR1 mRNA expression by reverse transcriptase polymerase chain reaction were confirmed by immunostaining using the anti-P-glycoprotein monoclonal antibody UIC2 and by a functional study using the rhodamine efflux test. Rhodamines 211-220 ATP binding cassette subfamily B member 1 Homo sapiens 15-19 8105101-12 1993 MDR1 mRNA expression was significantly correlated with rhodamine 123 efflux, whereas MDR3 mRNA expression was not significantly correlated; MDR1 and MDR3 mRNA expression was not significantly associated with Rai stage, prior treatment, or disease progresssion. Rhodamines 55-64 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 8105110-11 1993 A verapamil-sensitive drug efflux has been demonstrated for the PC-3 and Du-145, but not for the LNCaP, cell lines, using flow cytometric measurements of the P-gp substrate rhodamine 123 efflux from preloaded cells. Rhodamines 173-182 ATP binding cassette subfamily B member 1 Homo sapiens 158-162 7680244-2 1993 In this study, expression of multidrug resistance P-glycoprotein on peripheral blood mononuclear cells (PBMC) of 11 patients with GLPD was examined by staining with MRK 16, a monoclonal antibody that binds to an external epitope of P-glycoprotein, and with the dye rhodamine, a known substance to be excreted from the cells through P-glycoprotein. Rhodamines 265-274 ATP binding cassette subfamily B member 1 Homo sapiens 50-64 35209208-1 2022 BACKGROUND: rhodamines are dyes widely used as fluorescent tags in cell imaging, probing of mitochondrial membrane potential, and as P-glycoprotein model substrates. Rhodamines 12-22 ATP binding cassette subfamily B member 1 Homo sapiens 133-147 1969768-1 1990 P-glycoprotein (P-gp) is involved in the transport of a wide variety of organic compounds including a fluorescent dye, rhodamine 6G (RG), as well as anti-cancer drugs. Rhodamines 119-128 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 1969768-1 1990 P-glycoprotein (P-gp) is involved in the transport of a wide variety of organic compounds including a fluorescent dye, rhodamine 6G (RG), as well as anti-cancer drugs. Rhodamines 119-128 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 2480910-8 1989 Rhodamine-losing T-lymphoma contained large amounts of the mRNA coding P-glycoprotein, the MDR efflux pump, and demonstrated increased resistance to rhodamine 123, gramicidin D, colchicine, and vincristine, the drugs belonging to the cross-resistance group for the MDR cells. Rhodamines 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 71-85