PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14585326-6 2003 Nafoxidine inhibited the Pgp pump activity as measured by rhodamine 123 efflux. Rhodamines 58-67 phosphoglycolate phosphatase Homo sapiens 25-28 15661399-6 2005 P-gp interaction with GC was assessed by modulation of rhodamine accumulation. Rhodamines 55-64 phosphoglycolate phosphatase Homo sapiens 0-4 10541289-7 1999 This study found: (1) PAF C-16 and analogs inhibited Pgp-mediated efflux of rhodamine 123 by 59 to 88% in multidrug-resistant KBV-1 cells and by 85 to 97% in cultured human mesangial cells. Rhodamines 76-85 phosphoglycolate phosphatase Homo sapiens 53-56 12223492-3 2002 One class of compounds transported by P-gp is the rhodamine dyes. Rhodamines 50-59 phosphoglycolate phosphatase Homo sapiens 38-42 12223492-4 2002 A P-gp deletion mutant (residues 1-379 plus 681-1025) with only the TM domains retained the ability to bind rhodamine. Rhodamines 108-117 phosphoglycolate phosphatase Homo sapiens 2-6 11877073-7 2001 Rhodamine 123 efflux showed 16% transduced cells with P-gp function. Rhodamines 0-9 phosphoglycolate phosphatase Homo sapiens 54-58 11205902-3 2001 Flavopiridol at a concentration of 10 microM was able to prevent MRP-mediated calcein efflux, whereas Pgp-mediated transport of rhodamine 123 was unaffected at flavopiridol concentrations of up to 100 microM. Rhodamines 128-137 phosphoglycolate phosphatase Homo sapiens 102-105 9029024-3 1997 Pgp was measured in CD34+ progenitors with a rhodamine efflux assay. Rhodamines 45-54 phosphoglycolate phosphatase Homo sapiens 0-3 9476146-2 1998 Pgp can be detected in human cancers by immunohistochemistry, RNA probes, or by functional assays utilizing transported fluorescent dyes such as rhodamine. Rhodamines 145-154 phosphoglycolate phosphatase Homo sapiens 0-3 9890665-6 1998 Activity of plasma membrane Pgp was examined in parental and resistant cells due to rhodamine-accumulation assay. Rhodamines 84-93 phosphoglycolate phosphatase Homo sapiens 28-31 9150713-3 1997 The intracellular rhodamine (Rh123) contents also increased in P-gp-positive blasts and K562/ADM cells with MS-209. Rhodamines 18-27 phosphoglycolate phosphatase Homo sapiens 63-67 9029024-5 1997 Pgp measured by the monoclonal antibody antibody (MoAb) MRK-16 was low in the rhodamine dull, but significantly (P < 0.04) higher than in the rhodamine bright cells. Rhodamines 78-87 phosphoglycolate phosphatase Homo sapiens 0-3 9029024-5 1997 Pgp measured by the monoclonal antibody antibody (MoAb) MRK-16 was low in the rhodamine dull, but significantly (P < 0.04) higher than in the rhodamine bright cells. Rhodamines 145-154 phosphoglycolate phosphatase Homo sapiens 0-3 29421572-7 2018 Two long-lasting P-gp pump modulators (9 and 10) were identified; they were able to inhibit remarkably the P-gp substrate rhodamine-123 efflux on the resistant K562/DOX cell line after 60 min. Rhodamines 122-131 phosphoglycolate phosphatase Homo sapiens 17-21 8616825-7 1996 Moreover we could correlate MDR1 gene expression and modulation of rhodamine 123 efflux from the leukaemic blasts by proven P-gp MDR chemosensitizing agents such as SDZ PSC 833, dexverapamil and dexniguldipine. Rhodamines 67-76 phosphoglycolate phosphatase Homo sapiens 124-128 29709579-2 2018 In this study we measured the inhibitory behaviour of a set of known drugs towards P-gp by using three different probe substrates (digoxin, Hoechst 33,342 and rhodamine 123). Rhodamines 159-168 phosphoglycolate phosphatase Homo sapiens 83-87 7507731-10 1994 Flow cytometric analysis of rhodamine 123 dye efflux indicated a functional P-gp that was efficiently blocked by verapamil or cyclosporin A (CsA). Rhodamines 28-37 phosphoglycolate phosphatase Homo sapiens 76-80 30947123-6 2019 Ten selected non-hydrolysable derivatives were able to inhibit the P-gp-mediated rhodamine-123 efflux on K562/DOX cells, and the evaluation of their apparent permeability and ATP consumption on other cell lines suggested that the compounds can behave as unambiguous or not transported substrates. Rhodamines 81-90 phosphoglycolate phosphatase Homo sapiens 67-71 30166110-13 2018 ATE-Hex reduced the rhodamine efflux in MES-SA/Dx5 cells, indicating that ATE-Hex could reduce the expression of P-gp. Rhodamines 20-29 phosphoglycolate phosphatase Homo sapiens 113-117 29421572-7 2018 Two long-lasting P-gp pump modulators (9 and 10) were identified; they were able to inhibit remarkably the P-gp substrate rhodamine-123 efflux on the resistant K562/DOX cell line after 60 min. Rhodamines 122-131 phosphoglycolate phosphatase Homo sapiens 107-111 28068095-4 2017 In addition, 7a induced the mitochondrial tyrosine nitration and the intracellular accumulation of rhodamine 123 by inhibiting P-gp activity in K562/A02 cells. Rhodamines 99-108 phosphoglycolate phosphatase Homo sapiens 127-131 28114946-9 2017 Specifically, the rate of permeability of Rhodamine 123 across the BBB model (0.6 +- 0.1 x 10-3, n = 4), increased 14-fold in the presence of the P-gp inhibitor verapamil (14.7 +- 7.5 x 10-3, n = 3) and eightfold with the addition of Cyclosporine A (8.8 +- 1.8 x 10-3, n = 3). Rhodamines 42-51 phosphoglycolate phosphatase Homo sapiens 146-150 27720954-1 2016 In this present study, the secretory transport of P-gp substrates, rhodamine 123 and digoxin, was evaluated using a Caco-2/HT29-MTX co-culture characterized by an efflux mechanism and a paracellular permeability closer to the human intestinal barrier compared to the Caco-2 monolayer gold standard. Rhodamines 67-76 phosphoglycolate phosphatase Homo sapiens 50-54 27720954-3 2016 Labrasol ALF and Gelucire 44/14 in saline buffer significantly decreased to 83% and 62%, the P-gp-mediated transport of rhodamine 123 across the co-culture, respectively. Rhodamines 122-131 phosphoglycolate phosphatase Homo sapiens 95-99 26265061-7 2015 P-gp inhibitory potential of Pl-g-CH was proved by flow cytometry and fluorescence microscopy where the much enhanced fluorescence intensity of Rhodamine 123 (Rho-123, P-gp substrate) was observed in the presence of Pl-g-CH. Rhodamines 144-153 phosphoglycolate phosphatase Homo sapiens 0-4 26265061-7 2015 P-gp inhibitory potential of Pl-g-CH was proved by flow cytometry and fluorescence microscopy where the much enhanced fluorescence intensity of Rhodamine 123 (Rho-123, P-gp substrate) was observed in the presence of Pl-g-CH. Rhodamines 144-153 phosphoglycolate phosphatase Homo sapiens 168-172 26757548-5 2015 When pretreatment with MRP2 siRNA-3 or P-gp siRNA-2, the efflux of methotrexate or rhodamine decreased significantly and the intra-cellular concentration increased. Rhodamines 83-92 phosphoglycolate phosphatase Homo sapiens 39-43 19898868-6 2010 Doxorubicin also induced up-regulation of P-gp functional activities, as intracellular retention of rhodamine was decreased; however, 2.0 microg/ml tetrandrine significantly inhibited the overexpression of doxorubicin-induced mdr1 mRNA/P-gp. Rhodamines 100-109 phosphoglycolate phosphatase Homo sapiens 42-46 25765837-7 2015 The lignans can increase the retention of the P-gp substrate rhodamine 123 in CEM/ADR 5000 cells, indicating that lignans can inhibit the activity of P-gp. Rhodamines 61-70 phosphoglycolate phosphatase Homo sapiens 46-50 25765837-7 2015 The lignans can increase the retention of the P-gp substrate rhodamine 123 in CEM/ADR 5000 cells, indicating that lignans can inhibit the activity of P-gp. Rhodamines 61-70 phosphoglycolate phosphatase Homo sapiens 150-154 25121365-6 2014 P-gp activity was measured by flow cytometry using rhodamine efflux. Rhodamines 51-60 phosphoglycolate phosphatase Homo sapiens 0-4 23035695-5 2012 Concomitantly, P-gp protein expression increased 2.5-fold and was accompanied by a 20-35% reduction in cellular accumulation of the P-gp substrates, rhodamine 6G (R6G), and HiLyte Fluor 488-labeled human amyloid beta 1-42 (hAbeta(42)). Rhodamines 149-158 phosphoglycolate phosphatase Homo sapiens 15-19 25725134-6 2015 The P-gp efflux efficiency was assessed by rhodamine 123 transport. Rhodamines 43-52 phosphoglycolate phosphatase Homo sapiens 4-8 25433164-11 2015 Functionality of P-gp assessed with Rhodamine permeability did not change with passage number in Caco-2 cells with any of the protocols but increased in both protocols in MDCK and MDCK-MDR1 cells. Rhodamines 36-45 phosphoglycolate phosphatase Homo sapiens 17-21 23183822-10 2012 Of note, miR-211- and pM-treated CSC demonstrated increased drug retention capacity, as observed by MDR1/P-gp mediated-Rhodamine 123 drug efflux activity assay. Rhodamines 119-128 phosphoglycolate phosphatase Homo sapiens 105-109 20196146-5 2011 Rhodamine assay also revealed that hydrocinchonine, cinchonine, and quinidine effectively enhanced the accumulation of a P-gp substrate, rhodamine in TAX-treated MES-SA/DX5 cells compared with TAX-treated control. Rhodamines 0-9 phosphoglycolate phosphatase Homo sapiens 121-125 20196146-5 2011 Rhodamine assay also revealed that hydrocinchonine, cinchonine, and quinidine effectively enhanced the accumulation of a P-gp substrate, rhodamine in TAX-treated MES-SA/DX5 cells compared with TAX-treated control. Rhodamines 137-146 phosphoglycolate phosphatase Homo sapiens 121-125 20955791-3 2011 P-gp and CYP3A4 activities were assayed by [(3)H]digoxin and rhodamine 123 cellular retention and testosterone 6beta-hydroxylation, respectively. Rhodamines 61-70 phosphoglycolate phosphatase Homo sapiens 0-4 22358098-7 2011 Moreover, DIOXOL (at 10 muM) significantly inhibited P-gp transport function by more than twofold comparing to control, untreated cells that was demonstrated using rhodamine 123-based functional test. Rhodamines 164-173 phosphoglycolate phosphatase Homo sapiens 53-57 19309222-10 2009 Rhodamine retention alone and in the presence of cyclosporine was the lowest in imatinib-resistant K-562R-0.1 cell line, what suggest high PGP activity in this cell line. Rhodamines 0-9 phosphoglycolate phosphatase Homo sapiens 139-142 19041851-4 2009 Moreover, expression of P-gp and BCRP was lower in hCMEC/D3 than in human brain microvessels but remain functional as shown by rhodamine 123 efflux assay. Rhodamines 127-136 phosphoglycolate phosphatase Homo sapiens 24-28 19783150-3 2010 In addition to being lipophilic cations, like (99m)Tc-MIBI, rhodamine dyes are known to accumulate in the myocardium and are substrates for Pgp, the protein implicated in MDR1 multidrug resistance. Rhodamines 60-69 phosphoglycolate phosphatase Homo sapiens 140-143 19549365-7 2009 The function of P-gp in K562/A02 cells weakened along with decrease of intracellular acidification, the intracellular acidification significantly increased the accumulation of Rhodamine 123 (Rh 123) and suppressed the efflux of Rh 123 mediated by P-gp. Rhodamines 176-185 phosphoglycolate phosphatase Homo sapiens 16-20 17701591-3 2007 Ex vivo treatment of CLL cells with HF markedly impaired the activity of P-gp, as measured by the inhibition of the capacity of the treated cells to efflux the rhodamine 123 probe. Rhodamines 160-169 phosphoglycolate phosphatase Homo sapiens 73-77 17054045-9 2006 P. amarus derivatives were also found to be effective in inhibiting Pgp activity as assessed by rhodamine accumulation in Lucena-1 cells, as were the classical Pgp inhibitors, cyclosporine A (160 nM), PSC-833 (2 microM) and verapamil (5 microM). Rhodamines 96-105 phosphoglycolate phosphatase Homo sapiens 68-71