PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22913740-6 2014 In addition, the dye was found to inhibit hOCT1- and hOCT2-mediated uptake of tetraethylammonium (TEA), a model substrate for both hOCT1 and hOCT2; rhodamine 123 appeared nevertheless to be a more potent inhibitor of hOCT1-mediated TEA transport (IC50 = 0.37 mum) than of that mediated by hOCT2 (IC50 = 61.5 mum). Rhodamines 148-157 solute carrier family 22 member 2 Homo sapiens 53-58 22913740-4 2014 This increase of rhodamine 123 influxes was found to be a saturable carrier-mediated process, with low K(m) values (K(m) = 0.54 mum and K(m) = 0.61 mum for transport of the dye in hOCT1- and hOCT2-positive HEK293 cells, respectively). Rhodamines 17-26 solute carrier family 22 member 2 Homo sapiens 191-196 22913740-6 2014 In addition, the dye was found to inhibit hOCT1- and hOCT2-mediated uptake of tetraethylammonium (TEA), a model substrate for both hOCT1 and hOCT2; rhodamine 123 appeared nevertheless to be a more potent inhibitor of hOCT1-mediated TEA transport (IC50 = 0.37 mum) than of that mediated by hOCT2 (IC50 = 61.5 mum). Rhodamines 148-157 solute carrier family 22 member 2 Homo sapiens 141-146 22913740-6 2014 In addition, the dye was found to inhibit hOCT1- and hOCT2-mediated uptake of tetraethylammonium (TEA), a model substrate for both hOCT1 and hOCT2; rhodamine 123 appeared nevertheless to be a more potent inhibitor of hOCT1-mediated TEA transport (IC50 = 0.37 mum) than of that mediated by hOCT2 (IC50 = 61.5 mum). Rhodamines 148-157 solute carrier family 22 member 2 Homo sapiens 141-146 22913740-7 2014 Taken together, these data demonstrate that rhodamine 123 is a high-affinity substrate for both hOCT1 and hOCT2. Rhodamines 44-53 solute carrier family 22 member 2 Homo sapiens 106-111