PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28235604-9 2017 The expression and function of P-gp were measured by Western blotting, quantitative real-time polymerase chain reaction (qRT-PCR) and flow cytometry using rhodamine efflux. Rhodamines 155-164 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 31-35 24041929-4 2013 rhodamine 123 acts as a good substrate for P-glycoprotein, and agents that block P-glycoprotein have been found to increase the retention of rhodamine in cells. Rhodamines 141-150 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 81-95 24735764-13 2014 CONCLUSIONS: This study showed reduced function of P-glycoprotein in ischemia-reperfusion injury as reflected by decreased biliary excretion of Rhodamine 123, as well as reduced protein expression of the transporter. Rhodamines 144-153 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 51-65 24041929-4 2013 rhodamine 123 acts as a good substrate for P-glycoprotein, and agents that block P-glycoprotein have been found to increase the retention of rhodamine in cells. Rhodamines 0-9 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 43-57 25730814-0 2015 Rhodamine-123: a p-glycoprotein marker complex with sodium lauryl sulfate. Rhodamines 0-9 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 17-31 23234641-4 2013 Here we validate the new dye-probe beta-amyloid (1-40) HiLyte Fluor TR-labeled (Ab-HiLyte) (Anaspec) P-gp mediated transport in the ex vivo rat everted gut sac assay by using MC18 or MC266, a fully characterized P-gp inhibitor and substrate, respectively, and compare it with the commonly used dye rhodamine. Rhodamines 299-308 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 102-106 23234641-4 2013 Here we validate the new dye-probe beta-amyloid (1-40) HiLyte Fluor TR-labeled (Ab-HiLyte) (Anaspec) P-gp mediated transport in the ex vivo rat everted gut sac assay by using MC18 or MC266, a fully characterized P-gp inhibitor and substrate, respectively, and compare it with the commonly used dye rhodamine. Rhodamines 299-308 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 213-217 18403942-1 2008 OBJECTIVES: The present study was aimed at evaluation of in vivo biliary and renal excretion of rhodamine 123 (Rho123), a P-glycoprotein (P-gp) substrate, in rats during either acute or chronic cholestasis induced by bile duct obstruction (BDO). Rhodamines 96-105 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 122-136 21685928-4 2011 P-GP function was investigated via measuring tissue-to-plasma concentration ratios and body fluid excretion percentages of rhodamine 123. Rhodamines 123-132 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 20955690-6 2011 MDR1 activity was increased by 50% in APAP treated rats, as evaluated by serosal to mucosal secretion of rhodamine 123 in everted intestinal sacs. Rhodamines 105-114 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 19814863-6 2009 Verapamil, a competitive inhibitor of P-gp, significantly inhibited ileal clearance of rhodamine 123 to the lumen at 24 h after reperfusion, suggesting that P-gp was working at this time. Rhodamines 87-96 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 38-42 19814863-6 2009 Verapamil, a competitive inhibitor of P-gp, significantly inhibited ileal clearance of rhodamine 123 to the lumen at 24 h after reperfusion, suggesting that P-gp was working at this time. Rhodamines 87-96 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 157-161 19465096-4 2009 P-glycoprotein (P-gp) does not affect melatonin absorption but transported rhodamine 123, a well-known P-gp substrate. Rhodamines 75-84 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-14 19465096-4 2009 P-glycoprotein (P-gp) does not affect melatonin absorption but transported rhodamine 123, a well-known P-gp substrate. Rhodamines 75-84 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 16-20 19465096-4 2009 P-glycoprotein (P-gp) does not affect melatonin absorption but transported rhodamine 123, a well-known P-gp substrate. Rhodamines 75-84 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 103-107 18403942-1 2008 OBJECTIVES: The present study was aimed at evaluation of in vivo biliary and renal excretion of rhodamine 123 (Rho123), a P-glycoprotein (P-gp) substrate, in rats during either acute or chronic cholestasis induced by bile duct obstruction (BDO). Rhodamines 96-105 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 138-142 15663893-3 2005 The amount of intracellular rhodamine (Rh123) was determined, using a fluorescence spectrophotometer, to evaluate the function of P-gp. Rhodamines 28-37 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 130-134 16124934-7 2005 P-gp function was evaluated by the difference between rhodamine 123 transport with and without verapamil. Rhodamines 54-63 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 12626638-0 2003 Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. Rhodamines 92-101 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 42-56 12138126-8 2002 Furthermore, using rhodamine 123 efflux assay we observed a significant increase in P-gp activity in Cox-2 overexpressing renal mesangial cells. Rhodamines 19-28 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 84-88 11428664-7 2001 In Caco-2 cells, plasma collected from CCl4-treated rats exhibited a greater inhibitory effect on P-glycoprotein-mediated transport of rhodamine 123 than that from control rats, suggesting the accumulation of an endogenous P-glycoprotein substrate/inhibitor in the plasma of diseased rats. Rhodamines 135-144 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 98-112 11477162-6 2001 RESULTS: A decrease of intestinal rhodamine 123 transport was observed in chronic renal failure rats, pointing to an inhibition of P-glycoprotein activity. Rhodamines 34-43 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 131-145 11477162-9 2001 CONCLUSIONS: Intestinal secretion of rhodamine 123 is mainly mediated by P-glycoprotein. Rhodamines 37-46 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 73-87 11445244-9 2001 EP 51389 inhibited P-gp in a dose dependent manner resulting in the intracellular accumulation of rhodamine in CH(R)C5 cells. Rhodamines 98-107 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 19-23 12226838-0 2002 Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes. Rhodamines 49-58 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 25-39 11428664-7 2001 In Caco-2 cells, plasma collected from CCl4-treated rats exhibited a greater inhibitory effect on P-glycoprotein-mediated transport of rhodamine 123 than that from control rats, suggesting the accumulation of an endogenous P-glycoprotein substrate/inhibitor in the plasma of diseased rats. Rhodamines 135-144 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 223-237 11040353-2 2000 The in vivo function of P-glycoprotein was evaluated by measuring renal secretory and biliary clearance and brain distribution of rhodamine 123 (Rho-123), a P-glycoprotein substrate, under a steady-state plasma concentration. Rhodamines 130-139 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 24-38 9744774-9 1998 There was no measurable decline in the fura2 free acid fluorescence in 1 h while the fluorescence due to rhodamine 123 diminished rapidly in cells overexpressing Pgp. Rhodamines 105-114 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 162-165 9821664-8 1998 These results imply that rhodamine 123 is secreted via P-glycoprotein in renal tubules and that the renal secretory clearance of rhodamine 123 was reduced after acute renal failure, probably because of impairment of P-glycoprotein. Rhodamines 25-34 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 55-69 7912496-5 1994 Our results indicate that monitoring the biliary rhodamine 123 secretion in the isolated perfused liver of TR- rats offers a new system for testing modulators of P-glycoprotein like cyclosporin A. Rhodamines 49-58 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 162-176 7912496-0 1994 Inhibition of rhodamine 123 secretion by cyclosporin A as a model of P-glycoprotein mediated transport in liver. Rhodamines 14-23 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 69-83 7912496-4 1994 Both cyclosporin A and rhodamine inhibited photoaffinity labeling of immunoprecipitated P-glycoprotein with azidopine, indicating binding to hepatic P-glycoprotein. Rhodamines 23-32 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 88-102 7912496-4 1994 Both cyclosporin A and rhodamine inhibited photoaffinity labeling of immunoprecipitated P-glycoprotein with azidopine, indicating binding to hepatic P-glycoprotein. Rhodamines 23-32 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 149-163 7905358-0 1993 Assessment of P-glycoprotein-dependent drug transport in isolated rat hepatocytes using rhodamine 123. Rhodamines 88-97 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 14-28 32469522-1 2020 he aim of the present paper is to study the effect of common excipients on the permeability of atenolol (as drug absorbed mainly by passive diffusion) and rhodamine (as P-Glycoprotein substrate). Rhodamines 155-164 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 169-183