PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16120190-0	2005	Inhibition of human CYP1A2 oxidation of 5,6-dimethyl-xanthenone-4-acetic acid by acridines: a molecular modelling study.	Acridines	81-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26	
16120190-2	2005	The aim of the present study was to investigate the structural requirements for the inhibition of 6-methyl-hydroxylation of the antitumour agent 5,6-dimethyl-xanthenone-4-acetic acid (DMXAA) by acridine analogues and use a CYP1A2 homology model to provide some insight into this interaction.	Acridines	194-202	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	223-229	
16120190-5	2005	Some of the acridines were also tested for their ability to inhibit the CYP1A2-mediated 7-ethoxyresorufin O-de-ethylation.	Acridines	12-21	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-78	
16120190-9	2005	Similar structural trends were observed for the inhibition of O-de-ethylation of 7-ethoxyresorufin by acridines, supporting the involvement of CYP1A2 in DMXAA 6-methyl hydroxylation.	Acridines	102-111	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	143-149