PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27264436-0 2016 Ginkgo biloba and vitamin E ameliorate haloperidol-induced vacuous chewingmovement and brain-derived neurotrophic factor expression in a rat tardive dyskinesia model. Haloperidol 39-50 brain-derived neurotrophic factor Rattus norvegicus 87-120 28410959-2 2017 This study examined the role of brain derived neurotrophic factor (BDNF)-cAMP response element binding (CREB) protein signaling pathways, including protein kinase B (AKT), glycogen synthase kinase (GSK)-3beta and related molecules in the molecular response to haloperidol, fluvoxamine, combined haloperidol+fluvoxamine and clozapine treatments in rat frontal cortex, hippocampus and primary cortical neuronal cultures. Haloperidol 260-271 brain-derived neurotrophic factor Rattus norvegicus 67-71 28410959-2 2017 This study examined the role of brain derived neurotrophic factor (BDNF)-cAMP response element binding (CREB) protein signaling pathways, including protein kinase B (AKT), glycogen synthase kinase (GSK)-3beta and related molecules in the molecular response to haloperidol, fluvoxamine, combined haloperidol+fluvoxamine and clozapine treatments in rat frontal cortex, hippocampus and primary cortical neuronal cultures. Haloperidol 295-306 brain-derived neurotrophic factor Rattus norvegicus 67-71 28410959-4 2017 Chronic haloperidol (1mg/kg) +fluvoxamine (10mg/kg) treatment increased TrkB receptor and BDNF expression levels, and the phosphorylation of AKT/CREB/GSK-3beta, compared to the individual drugs in rat brain. Haloperidol 8-19 brain-derived neurotrophic factor Rattus norvegicus 90-94 27381554-10 2016 Haloperidol+ORM-10921 significantly reversed reduced striatal BDNF levels in SIR rats. Haloperidol 0-11 brain-derived neurotrophic factor Rattus norvegicus 62-66 27264436-7 2016 Haloperidol also decreased BDNF expression in all four brain regions, but both EGb761 and vitamin E administration significantly increased BDNF expression. Haloperidol 0-11 brain-derived neurotrophic factor Rattus norvegicus 27-31 18433734-6 2008 Chronic administration of the typical antipsychotic haloperidol (1 mg/kg) and the atypical antipsychotic clozapine (20 mg/kg) increased BDNF levels by only 8-10% in the frontal cortex. Haloperidol 52-63 brain-derived neurotrophic factor Rattus norvegicus 136-140 21893111-3 2011 In this study, we analyzed the effects of the atypical antipsychotic drugs olanzapine and aripiprazole and a typical antipsychotic drug, haloperidol, on the expression of BDNF, phosphorylated GSK-3beta, and beta-catenin in the hippocampus of rats subjected to immobilization stress. Haloperidol 137-148 brain-derived neurotrophic factor Rattus norvegicus 171-175 17805306-0 2008 Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF. Haloperidol 24-35 brain-derived neurotrophic factor Rattus norvegicus 95-99 17805306-3 2008 For example, our previous studies in rats indicated that chronic treatment with the conventional antipsychotic, haloperidol, was associated with decreases in BDNF (and other neurotrophins) in the brain as well as deficits in cognitive function (an especially important consideration for the therapeutics of schizophrenia). Haloperidol 112-123 brain-derived neurotrophic factor Rattus norvegicus 158-162 17805306-7 2008 Such observations provided the impetus for us to investigate in the present study whether co-treatment of rhEPO with haloperidol could sustain the normal levels of BDNF in vivo in rats and in vitro in cortical neuronal cultures and further, whether BDNF could prevent haloperidol-induced apoptosis through the regulation of key apoptotic/antiapoptotic markers. Haloperidol 117-128 brain-derived neurotrophic factor Rattus norvegicus 164-168 17805306-8 2008 The results indicated that rhEPO prevented the haloperidol-induced reduction in BDNF in both in vivo and in vitro experimental conditions. Haloperidol 47-58 brain-derived neurotrophic factor Rattus norvegicus 80-84 17805306-9 2008 The sustained levels of BDNF in rats with rhEPO prevented the haloperidol-induced increase in caspase-3 (p<0.05) and decrease in Bcl-xl (p<0.01) protein levels. Haloperidol 62-73 brain-derived neurotrophic factor Rattus norvegicus 24-28 18496748-4 2008 The present study aims to investigate the effect of chronic treatment with antipsychotics, named haloperidol (HAL), clozapine (CLO), olanzapine (OLZ) or aripiprazole (ARI) on BDNF and NGF levels in rat hippocampus. Haloperidol 97-108 brain-derived neurotrophic factor Rattus norvegicus 175-179 25446926-5 2014 Haloperidol decrease by a third hippocampal BDNF and acetylcholine esterase (but not GAD67) expression, which was normalized by mildronate; it also reversed the haloperidol-induced memory impairment in Barnes test. Haloperidol 0-11 brain-derived neurotrophic factor Rattus norvegicus 44-48 18656896-0 2009 Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats. Haloperidol 40-51 brain-derived neurotrophic factor Rattus norvegicus 90-94 18656896-6 2009 Haloperidol strongly decreased the expression of BDNF mRNA in both the hippocampal and cortical regions, with or without immobilization stress (p<0.01). Haloperidol 0-11 brain-derived neurotrophic factor Rattus norvegicus 49-53 18786174-3 2008 Earlier studies from our laboratory have indicated that long-term treatment with haloperidol (HAL) decreases BDNF, reduced GSH and anti-apoptotic marker, Bcl-xl protein levels and increases the expression of pro-apoptotic proteins in rat frontal cortex. Haloperidol 81-92 brain-derived neurotrophic factor Rattus norvegicus 109-113 18786174-3 2008 Earlier studies from our laboratory have indicated that long-term treatment with haloperidol (HAL) decreases BDNF, reduced GSH and anti-apoptotic marker, Bcl-xl protein levels and increases the expression of pro-apoptotic proteins in rat frontal cortex. Haloperidol 94-97 brain-derived neurotrophic factor Rattus norvegicus 109-113 18433734-7 2008 Haloperidol also elevated BDNF levels in the amygdala, while clozapine decreased BDNF in the olfactory bulb. Haloperidol 0-11 brain-derived neurotrophic factor Rattus norvegicus 26-30 18335055-8 2008 Long-term treatment with antipsychotic drugs, haloperidol and olanzapine, showed differential effects on both Sprouty2 and BDNF mRNA and protein levels in the frontal cortex of rats. Haloperidol 46-57 brain-derived neurotrophic factor Rattus norvegicus 123-127 12478621-2 2003 The typical antipsychotic drug haloperidol has been shown to cause a decrease in the expression of brain-derived neurotrophic factor (BDNF), which plays an important role in neuronal cell survival, differentiation, and neuronal connectivity. Haloperidol 31-42 brain-derived neurotrophic factor Rattus norvegicus 99-132 17442543-6 2007 Real-time PCR analysis revealed that HAL pretreatment significantly increased BDNF mRNA expression but did not alter c-fos and STAT-3 expression compared to rotenone-exposed cells. Haloperidol 37-40 brain-derived neurotrophic factor Rattus norvegicus 78-82 18660566-3 2008 In the present study, we used the MAM model to investigate in young rats the effect of antipsychotics, Clozapine and Haloperidol, on brain and blood NGF and BDNF presence. Haloperidol 117-128 brain-derived neurotrophic factor Rattus norvegicus 157-161 18660566-5 2008 The results showed that administration of Clozapine and Haloperidol causes significant changes in the concentration of NGF and BDNF in the brain and bloodstream of MAM-treated rats. Haloperidol 56-67 brain-derived neurotrophic factor Rattus norvegicus 127-131 17442543-3 2007 We also determined whether there were differential effects of RIP and HAL on the expression of brain-derived neurotrophic factor (BDNF), signal transducers and activators of transcription-3 (STAT-3), and the immediate early gene c-fos, as well as intracellular levels of calcium. Haloperidol 70-73 brain-derived neurotrophic factor Rattus norvegicus 95-128 14746882-0 2004 Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol. Haloperidol 120-131 brain-derived neurotrophic factor Rattus norvegicus 36-69 14746882-2 2004 We compared the effect of 45 day chronic exposure of HAL (2 mg/kg per day) to OLZ (10 mg/kg per day) on brain-derived neurotrophic factor (BDNF)) and its high affinity receptor TrkB in rat hippocampus. Haloperidol 53-56 brain-derived neurotrophic factor Rattus norvegicus 104-137 14746882-2 2004 We compared the effect of 45 day chronic exposure of HAL (2 mg/kg per day) to OLZ (10 mg/kg per day) on brain-derived neurotrophic factor (BDNF)) and its high affinity receptor TrkB in rat hippocampus. Haloperidol 53-56 brain-derived neurotrophic factor Rattus norvegicus 139-143 14746882-5 2004 HAL, but not OLZ, significantly reduced the levels of BDNF in hippocampus. Haloperidol 0-3 brain-derived neurotrophic factor Rattus norvegicus 54-58 14746882-7 2004 Furthermore, post-treatment with OLZ markedly restored the HAL treatment associated reductions in both BDNF and TrkB receptors in hippocampus. Haloperidol 59-62 brain-derived neurotrophic factor Rattus norvegicus 103-107 12478621-2 2003 The typical antipsychotic drug haloperidol has been shown to cause a decrease in the expression of brain-derived neurotrophic factor (BDNF), which plays an important role in neuronal cell survival, differentiation, and neuronal connectivity. Haloperidol 31-42 brain-derived neurotrophic factor Rattus norvegicus 134-138 12478621-5 2003 Quantitative analysis revealed that the typical antipsychotic drug haloperidol (1 mg/kg) down-regulated BDNF mRNA expression in both CA1 (P < 0.05) and dentate gyrus (P < 0.01) regions compared with vehicle control. Haloperidol 67-78 brain-derived neurotrophic factor Rattus norvegicus 104-108 12393228-6 2002 Whereas chronic haloperidol and high-dose risperidone significantly downregulated hippocampal BDNF mRNA, intermediate and lower doses of risperidone and clozapine were, unlike ritanserin, without effect when compared to controls. Haloperidol 16-27 brain-derived neurotrophic factor Rattus norvegicus 94-98 12393228-4 2002 In addition, whereas chronic treatment with the strong D2 receptor-blocker haloperidol significantly downregulated hippocampal BDNF mRNA, the selective 5-HT2 receptor-blocker ritanserin significantly upregulated CA1 hippocampal BDNF mRNA in comparison to controls. Haloperidol 75-86 brain-derived neurotrophic factor Rattus norvegicus 127-131 34523299-12 2021 In the HIP, CMS elevated BDNF mRNA levels that were suppressed by HAL and ARI treatments. Haloperidol 66-69 brain-derived neurotrophic factor Rattus norvegicus 25-29 10854034-5 2000 The induction of BDNF mRNA by MK-801 was attenuated by pre-treatment (1 h prior to MK-801 administration) with the antipsychotics, clozapine (25 mg/kg) and haloperidol (2 mg/kg), but not with the antidepressant desipramine (15 mg/kg). Haloperidol 156-167 brain-derived neurotrophic factor Rattus norvegicus 17-21 11488957-3 2001 To clarify the effects of antipsychotic drugs used in the therapy of schizophrenia on BDNF mRNA, we studied its expression in rats treated with clozapine and haloperidol and in rats with neonatal lesions of the ventral hippocampus, used as an animal model of schizophrenia. Haloperidol 158-169 brain-derived neurotrophic factor Rattus norvegicus 86-90 11071712-0 2001 Changes in the pattern of brain-derived neurotrophic factor immunoreactivity in the rat brain after acute and subchronic haloperidol treatment. Haloperidol 121-132 brain-derived neurotrophic factor Rattus norvegicus 26-59 11071712-6 2001 Three days of haloperidol administration dramatically decreased BDNF immunostaining in the neurons and fibers of the prefrontal cortex, hippocampus (dentate gyrus, CA2, and CA3), extended amygdala, and ventral tegmental area. Haloperidol 14-25 brain-derived neurotrophic factor Rattus norvegicus 64-68 11071712-9 2001 These results show that blockade of dopaminergic receptors with haloperidol rapidly downregulates BDNF in reward and emotional centers of the brain. Haloperidol 64-75 brain-derived neurotrophic factor Rattus norvegicus 98-102 10861791-0 2000 Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration. Haloperidol 113-124 brain-derived neurotrophic factor Rattus norvegicus 0-33 10861791-6 2000 We hypothesized that treatments with haloperidol or risperidone will affect synthesis/release of brain BDNF and tested this hypothesis by measuring BDNF and TrkB in rat brain regions after a 29-day-treatment with haloperidol or risperidone added to chow. Haloperidol 37-48 brain-derived neurotrophic factor Rattus norvegicus 103-107 10861791-6 2000 We hypothesized that treatments with haloperidol or risperidone will affect synthesis/release of brain BDNF and tested this hypothesis by measuring BDNF and TrkB in rat brain regions after a 29-day-treatment with haloperidol or risperidone added to chow. Haloperidol 37-48 brain-derived neurotrophic factor Rattus norvegicus 148-152 10861791-6 2000 We hypothesized that treatments with haloperidol or risperidone will affect synthesis/release of brain BDNF and tested this hypothesis by measuring BDNF and TrkB in rat brain regions after a 29-day-treatment with haloperidol or risperidone added to chow. Haloperidol 213-224 brain-derived neurotrophic factor Rattus norvegicus 103-107 10861791-9 2000 Both haloperidol and risperidone significantly decreased BDNF concentrations in frontal cortex, occipital cortex and hippocampus and decreased or increased TrkB receptors in selected brain structures. Haloperidol 5-16 brain-derived neurotrophic factor Rattus norvegicus 57-61 34523299-0 2021 Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress. Haloperidol 0-11 brain-derived neurotrophic factor Rattus norvegicus 43-47 34523299-4 2021 The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures. Haloperidol 100-111 brain-derived neurotrophic factor Rattus norvegicus 200-204 34523299-4 2021 The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures. Haloperidol 113-116 brain-derived neurotrophic factor Rattus norvegicus 200-204 34523299-11 2021 The CMS and HAL suppressed the BDNF and GR mRNA levels in the PFC. Haloperidol 12-15 brain-derived neurotrophic factor Rattus norvegicus 31-35 34211274-0 2021 Effect of 5-HT6 Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats. Haloperidol 47-58 brain-derived neurotrophic factor Rattus norvegicus 122-126 32483475-0 2020 Haloperidol"s Effect on the Expressions of TGFB, NT-3, and BDNF genes in Cultured Rat Microglia. Haloperidol 0-11 brain-derived neurotrophic factor Rattus norvegicus 59-63