PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24128677-7 2013 Patients with MTLE + D taking fluoxetine showed greater BDNF immunoreactivity than those not taking fluoxetine; MTLE + P patients taking haloperidol had decreased neuronal density and immunoreactivity for NGF and BDNF in specific subfields versus those not taking haloperidol. Haloperidol 137-148 brain derived neurotrophic factor Homo sapiens 213-217 22945197-9 2012 Haloperidol also lowers BDNF levels, reducing neuroprotection in the brain to enable haloperidol"s toxic effects. Haloperidol 0-11 brain derived neurotrophic factor Homo sapiens 24-28 15168214-9 2004 Moreover, brain-derived neurotrophic factor (BDNF) reduced the caspase-3 activity and protected neurons from haloperidol-induced apoptosis. Haloperidol 109-120 brain derived neurotrophic factor Homo sapiens 10-43 20218789-3 2010 We measured serum BDNF levels in 47 patients with schizophrenia during a relapse and again 6 weeks after administration of antipsychotic treatment (14 on risperidone, 18 on haloperidol, 10 on olanzapine and five on amisulpride) and in 44 healthy volunteers. Haloperidol 173-184 brain derived neurotrophic factor Homo sapiens 18-22 19196496-0 2009 Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells. Haloperidol 41-52 brain derived neurotrophic factor Homo sapiens 56-60 19196496-3 2009 In the present study, we compared the SGA aripiprazole with the FGA haloperidol in SH-SY5Y human neuroblastoma cells via brain-derived neurotrophic factor (BDNF)-mediated signaling, notably BDNF, glycogen synthase kinase-3beta (GSK-3beta), and B cell lymphoma protein-2 (Bcl-2). Haloperidol 68-79 brain derived neurotrophic factor Homo sapiens 121-154 19196496-3 2009 In the present study, we compared the SGA aripiprazole with the FGA haloperidol in SH-SY5Y human neuroblastoma cells via brain-derived neurotrophic factor (BDNF)-mediated signaling, notably BDNF, glycogen synthase kinase-3beta (GSK-3beta), and B cell lymphoma protein-2 (Bcl-2). Haloperidol 68-79 brain derived neurotrophic factor Homo sapiens 156-160 19196496-12 2009 The actions of signaling systems associated with BDNF may represent key targets for both aripiprazole and haloperidol, but the latter may be associated with distinct effects. Haloperidol 106-117 brain derived neurotrophic factor Homo sapiens 49-53 16442781-5 2006 Furthermore, since a preliminary study showed that 90-day treatment of HAL caused significant reductions in the expression of both NGF and BDNF the HAL-treated animals were then switched to SGAs for the next 90 days to assess the potential for restoration of trophic factor levels. Haloperidol 71-74 brain derived neurotrophic factor Homo sapiens 139-143 16442781-5 2006 Furthermore, since a preliminary study showed that 90-day treatment of HAL caused significant reductions in the expression of both NGF and BDNF the HAL-treated animals were then switched to SGAs for the next 90 days to assess the potential for restoration of trophic factor levels. Haloperidol 148-151 brain derived neurotrophic factor Homo sapiens 139-143 16442781-11 2006 Whereas, larger decreases in BDNF levels were observed with HAL or CPZ and intermediate decreases were observed with RISP after 90 days of treatment that continued to decline up to 180 days. Haloperidol 60-63 brain derived neurotrophic factor Homo sapiens 29-33 16442781-12 2006 Furthermore, switching HAL animals after 90 days of treatment to either RISP or OLZ for the next 90 days significantly restored levels of both NGF and BDNF in both the brain regions. Haloperidol 23-26 brain derived neurotrophic factor Homo sapiens 151-155 15168214-9 2004 Moreover, brain-derived neurotrophic factor (BDNF) reduced the caspase-3 activity and protected neurons from haloperidol-induced apoptosis. Haloperidol 109-120 brain derived neurotrophic factor Homo sapiens 45-49 15168214-10 2004 BDNF also reversed the reduced levels of phosphorylation of Akt caused by treatment with haloperidol. Haloperidol 89-100 brain derived neurotrophic factor Homo sapiens 0-4 14746882-3 2004 Since the use of OLZ is presently preferred over HAL in patients, effects of its post-treatment on HAL-induced changes in the expression of BDNF and its TrkB receptor were also investigated. Haloperidol 99-102 brain derived neurotrophic factor Homo sapiens 140-144 12749027-4 2003 MK-801 reduces the hippocampal expression of the neurotrophin; this effect was exacerbated by haloperidol, but it was normalized by olanzapine. Haloperidol 94-105 brain derived neurotrophic factor Homo sapiens 49-61 12749027-5 2003 Our data reveal a fine tuning of BDNF biosynthesis and a differential modulation by antipsychotic drugs when NMDA-mediated transmission is reduced, suggesting that haloperidol and olanzapine can produce different effects on brain plasticity through the modulation of BDNF expression. Haloperidol 164-175 brain derived neurotrophic factor Homo sapiens 33-37 12749027-5 2003 Our data reveal a fine tuning of BDNF biosynthesis and a differential modulation by antipsychotic drugs when NMDA-mediated transmission is reduced, suggesting that haloperidol and olanzapine can produce different effects on brain plasticity through the modulation of BDNF expression. Haloperidol 164-175 brain derived neurotrophic factor Homo sapiens 267-271 28188803-0 2017 Activation of the sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astroglia. Haloperidol 38-49 brain derived neurotrophic factor Homo sapiens 74-107 28188803-7 2017 Remarkably, however, two metabolites of haloperidol, haloperidol I and haloperidol II (reduced haloperidol), were discovered to facilitate BDNF secretion and this effect was antagonized by BD1063. Haloperidol 40-51 brain derived neurotrophic factor Homo sapiens 139-143 28188803-7 2017 Remarkably, however, two metabolites of haloperidol, haloperidol I and haloperidol II (reduced haloperidol), were discovered to facilitate BDNF secretion and this effect was antagonized by BD1063. Haloperidol 53-64 brain derived neurotrophic factor Homo sapiens 139-143 28188803-7 2017 Remarkably, however, two metabolites of haloperidol, haloperidol I and haloperidol II (reduced haloperidol), were discovered to facilitate BDNF secretion and this effect was antagonized by BD1063. Haloperidol 53-64 brain derived neurotrophic factor Homo sapiens 139-143 28188803-7 2017 Remarkably, however, two metabolites of haloperidol, haloperidol I and haloperidol II (reduced haloperidol), were discovered to facilitate BDNF secretion and this effect was antagonized by BD1063. Haloperidol 53-64 brain derived neurotrophic factor Homo sapiens 139-143 28188803-9 2017 These results demonstrate for the first time that haloperidol metabolites I and II facilitate the secretion of BDNF from astrocytes by acting as functionally selective S1R agonists. Haloperidol 50-61 brain derived neurotrophic factor Homo sapiens 111-115 29182611-3 2017 The present study examines the effects of a first-generation neuroleptic drug (FGA; haloperidol) and two second-generation neuroleptic drugs (SGAs; olanzapine and amisulpride) on the expression and levels of brain-derived neurotrophic factor (BDNF) in an astrocyte-like T98G glioblastoma cell line. Haloperidol 84-95 brain derived neurotrophic factor Homo sapiens 208-241 29182611-6 2017 Real-time PCR analysis demonstrates that, of the three tested neuroleptics, both haloperidol and olanzapine at a concentration of 5 microM (but not at 20 microM) increased BDNF mRNA expression with similar efficacy after 72-hour incubation. Haloperidol 81-92 brain derived neurotrophic factor Homo sapiens 172-176 12127475-5 2002 In addition to the studies of patients and volunteers, neuroleptic effects on BDNF levels were assessed by administering haloperidol to adult rats for 2 weeks or 5 months. Haloperidol 121-132 brain derived neurotrophic factor Homo sapiens 78-82