PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30544975-1	2018	The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine.	Tropisetron	163-174	solute carrier family 22 member 1	Homo sapiens	4-32	
30544975-1	2018	The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine.	Tropisetron	163-174	solute carrier family 22 member 1	Homo sapiens	34-38	
30544975-1	2018	The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine.	Tropisetron	163-174	solute carrier family 22 member 1	Homo sapiens	40-47	
23922447-11	2013	It remains to be determined whether genetic variants, disease conditions, or drugs that affect HNF1 activity may affect the pharmacokinetics and efficacy of OCT1-transported drugs such as morphine, tropisetron, ondansetron, tramadol, and metformin.	Tropisetron	198-209	solute carrier family 22 member 1	Homo sapiens	157-161	
20921968-3	2012	Both tropisetron and ondansetron inhibited ASP(+) uptake in OCT1-overexpressing HEK293 cells.	Tropisetron	5-16	solute carrier family 22 member 1	Homo sapiens	60-64	
20921968-7	2012	Nevertheless, OCT1 genotypes correlated with pharmacokinetics (n=45, P<0.05) and clinical efficacy (n=222, P<0.02) of ondansetron, the effect size of OCT1 genotypes on pharmacokinetics and efficacy was greater for tropisetron than for ondansetron.	Tropisetron	220-231	solute carrier family 22 member 1	Homo sapiens	14-18	
20921968-8	2012	In conclusion, in addition to the known effects of CYP2D6, OCT1 deficiency may increase efficacy of tropisetron and potentially of ondansetron by limiting their hepatic uptake.	Tropisetron	100-111	solute carrier family 22 member 1	Homo sapiens	59-63