PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31102695-1 2019 Lithocholic acid is a cytotoxic bile acid oxidized at the C-3 position by human cytochrome P450 3A (CYP3A) to form 3-ketocholanoic acid, but it is not known whether this metabolite is cytotoxic. 3-ketocholanoic acid 115-135 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 80-98 31102695-1 2019 Lithocholic acid is a cytotoxic bile acid oxidized at the C-3 position by human cytochrome P450 3A (CYP3A) to form 3-ketocholanoic acid, but it is not known whether this metabolite is cytotoxic. 3-ketocholanoic acid 115-135 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 100-105 31102695-4 2019 Our enzyme catalysis experiments indicated that human recombinant CYP3A5 in addition to CYP3A4, liver microsomes, and intestinal microsomes catalyzed lithocholic acid 3-oxidation to form 3-ketocholanoic acid. 3-ketocholanoic acid 187-207 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 88-94 27153105-0 2016 An ultra-high performance liquid chromatography-tandem mass spectrometric assay for quantifying 3-ketocholanoic acid: Application to the human liver microsomal CYP3A-dependent lithocholic acid 3-oxidation assay. 3-ketocholanoic acid 96-116 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 160-165 27153105-1 2016 Lithocholic acid (LCA), a hepatotoxic and carcinogenic bile acid, is metabolized to 3-ketocholanoic acid (3-KCA) by cytochrome P450 3A (CYP3A). 3-ketocholanoic acid 84-104 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 116-134 27153105-1 2016 Lithocholic acid (LCA), a hepatotoxic and carcinogenic bile acid, is metabolized to 3-ketocholanoic acid (3-KCA) by cytochrome P450 3A (CYP3A). 3-ketocholanoic acid 84-104 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 136-141