PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26004513-12 2015 P2Y2, P2Y4 and P2Y6 receptors expressed on the vascular smooth muscle are coupled to vasocontraction, and may have a role in pathophysiological conditions, when purines are released from damaged cells, or when there is damage to the protective barrier that is the endothelium. Purines 161-168 pyrimidinergic receptor P2Y4 Homo sapiens 6-10 28066160-8 2016 The "purinergic hypothesis" is that MS releases purines to act in an autocrine/paracrine manner to activate excitatory (P2Y1, P2Y4, P2Y6, and A2A/A2B) or inhibitory (P2Y12, A1, and A3) receptors to regulate 5-HT release. Purines 48-55 pyrimidinergic receptor P2Y4 Homo sapiens 126-130