PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14516190-0	2003	RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element.	Aminoglycosides	53-67	Rev	Human immunodeficiency virus 1	112-115	
14516190-1	2003	Semisynthetic aminoglycoside derivatives may provide a means to selectively target viral RNA sites, including the HIV-1 Rev response element (RRE).	Aminoglycosides	14-28	Rev	Human immunodeficiency virus 1	120-123	
14516190-5	2003	All the modified aminoglycosides exhibit a high affinity for the Rev binding site on the RRE (K(d) <or= 10 nM), but few compounds have a high specificity for the RRE.	Aminoglycosides	17-32	Rev	Human immunodeficiency virus 1	65-68	
11354359-0	2001	Binding of dimeric aminoglycosides to the HIV-1 rev responsive element (RRE) RNA construct.	Aminoglycosides	19-34	Rev	Human immunodeficiency virus 1	48-51	
11354359-1	2001	Through a series of elegant fluorescence measurements, particularly through stopped-flow kinetic measurements, it was recently demonstrated that aminoglycoside antibiotics are able to bind to the HIV-1 Rev responsive element (RRE) RNA construct in more than a 1:1 stoichiometry (Lacourciere, K. A.; Stivers, J. T.; Marino, J. P. Biocheminstry 2000, 39, 5630).	Aminoglycosides	145-159	Rev	Human immunodeficiency virus 1	202-205	
10364175-9	1999	This method was also useful to rapidly evaluate the potential of aminoglycoside antibiotics, to inhibit the Rev-RRE interaction.	Aminoglycosides	65-79	Rev	Human immunodeficiency virus 1	108-111	
11540136-1	1997	The specificity of neomycin B and related aminoglycoside antibiotics in their interaction with the Rev responsive element (RRE) of HIV-1 mRNA has been studied by directly observing the aminoglycoside-RNA complexes using surface plasmon resonance.	Aminoglycosides	42-56	Rev	Human immunodeficiency virus 1	99-102	
9222509-7	1997	Interestingly, the molecular basis for the AK.A-RNA interaction, as well as the mode of RNA binding differs from previously described aminoglycoside Rev inhibitors.	Aminoglycosides	134-148	Rev	Human immunodeficiency virus 1	149-152	
8402886-3	1993	Here we show that certain aminoglycoside antibiotics, in particular neomycin B, can block binding of the HIV Rev protein to its viral RNA recognition element.	Aminoglycosides	26-40	Rev	Human immunodeficiency virus 1	109-112