PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11354359-0 2001 Binding of dimeric aminoglycosides to the HIV-1 rev responsive element (RRE) RNA construct. Aminoglycosides 19-34 Rev Human immunodeficiency virus 1 48-51 14516190-0 2003 RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element. Aminoglycosides 53-67 Rev Human immunodeficiency virus 1 112-115 14516190-1 2003 Semisynthetic aminoglycoside derivatives may provide a means to selectively target viral RNA sites, including the HIV-1 Rev response element (RRE). Aminoglycosides 14-28 Rev Human immunodeficiency virus 1 120-123 14516190-5 2003 All the modified aminoglycosides exhibit a high affinity for the Rev binding site on the RRE (K(d) <or= 10 nM), but few compounds have a high specificity for the RRE. Aminoglycosides 17-32 Rev Human immunodeficiency virus 1 65-68 11354359-1 2001 Through a series of elegant fluorescence measurements, particularly through stopped-flow kinetic measurements, it was recently demonstrated that aminoglycoside antibiotics are able to bind to the HIV-1 Rev responsive element (RRE) RNA construct in more than a 1:1 stoichiometry (Lacourciere, K. A.; Stivers, J. T.; Marino, J. P. Biocheminstry 2000, 39, 5630). Aminoglycosides 145-159 Rev Human immunodeficiency virus 1 202-205 9222509-7 1997 Interestingly, the molecular basis for the AK.A-RNA interaction, as well as the mode of RNA binding differs from previously described aminoglycoside Rev inhibitors. Aminoglycosides 134-148 Rev Human immunodeficiency virus 1 149-152 10364175-9 1999 This method was also useful to rapidly evaluate the potential of aminoglycoside antibiotics, to inhibit the Rev-RRE interaction. Aminoglycosides 65-79 Rev Human immunodeficiency virus 1 108-111 11540136-1 1997 The specificity of neomycin B and related aminoglycoside antibiotics in their interaction with the Rev responsive element (RRE) of HIV-1 mRNA has been studied by directly observing the aminoglycoside-RNA complexes using surface plasmon resonance. Aminoglycosides 42-56 Rev Human immunodeficiency virus 1 99-102 8402886-3 1993 Here we show that certain aminoglycoside antibiotics, in particular neomycin B, can block binding of the HIV Rev protein to its viral RNA recognition element. Aminoglycosides 26-40 Rev Human immunodeficiency virus 1 109-112