PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31903111-4 2020 Methods: In this study, we investigated the role of protein arginine methyltransferase 6 (PRMT6) in aminoglycoside- and cisplatin-induced hair cell loss by using EPZ020411, a selective small molecule PRMT6 inhibitor, in vitro in neonatal mouse cochlear explants and in vivo in C57BL/6 mice. Aminoglycosides 100-114 protein arginine N-methyltransferase 6 Mus musculus 52-88 31903111-4 2020 Methods: In this study, we investigated the role of protein arginine methyltransferase 6 (PRMT6) in aminoglycoside- and cisplatin-induced hair cell loss by using EPZ020411, a selective small molecule PRMT6 inhibitor, in vitro in neonatal mouse cochlear explants and in vivo in C57BL/6 mice. Aminoglycosides 100-114 protein arginine N-methyltransferase 6 Mus musculus 90-95 31903111-12 2020 Conclusions: Our findings suggested that PRMT6 might serve as a new therapeutic target to prevent hearing loss caused by aminoglycoside- and cisplatin-induced ototoxicity by preventing ROS formation and modulating the mitochondria-related damage and apoptosis. Aminoglycosides 121-135 protein arginine N-methyltransferase 6 Mus musculus 41-46