PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23407963-6	2013	The ability of a particular aminoglycoside to inhibit protein synthesis and to activate the c-Jun N-terminal kinase (JNK) pathway correlated well with its ototoxic potential.	Aminoglycosides	28-42	mitogen-activated protein kinase 8	Homo sapiens	92-115	
23407963-6	2013	The ability of a particular aminoglycoside to inhibit protein synthesis and to activate the c-Jun N-terminal kinase (JNK) pathway correlated well with its ototoxic potential.	Aminoglycosides	28-42	mitogen-activated protein kinase 8	Homo sapiens	117-120	
23407963-7	2013	Finally, we report that a Food and Drug Administration-approved drug known to inhibit ribotoxic stress response also prevents JNK activation and improves hair cell survival, opening up novel strategies to prevent and treat aminoglycoside ototoxicity.	Aminoglycosides	223-237	mitogen-activated protein kinase 8	Homo sapiens	126-129	
15810654-4	2005	A cell permeable peptide designed specifically to inhibit JNK signaling has proven successful in in vivo models of both neuronal degeneration following cerebral ischemia and auditory hair cell degeneration following exposure to either acoustic trauma or a toxic level of an aminoglycoside antibiotic.	Aminoglycosides	274-288	mitogen-activated protein kinase 8	Homo sapiens	58-61	
20167005-8	2010	Inhibitors of JNK signaling pathway prevent apoptosis of auditory hair cells following electrode insertion trauma, acute labyrinthitis, acoustic trauma and aminoglycoside ototoxicity.	Aminoglycosides	156-170	mitogen-activated protein kinase 8	Homo sapiens	14-17	
15379608-3	2004	The activation of the inducible transcription factor c-Jun by N-terminal phosphorylation is a central event in JNK-mediated apoptosis of oxidative stress-damaged auditory hair cells following exposure to either acoustic trauma or a toxic level of an aminoglycoside antibiotic and also the apoptosis of auditory neurons as a consequence of a loss of the trophic support provided by the auditory hair cells.	Aminoglycosides	250-264	mitogen-activated protein kinase 8	Homo sapiens	111-114