PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29344655-10	2018	The results demonstrated that the secretion of the inflammatory cytokines TNF-alpha, IL-6 and IL-1beta by LPS-stimulated BV2 cells was significantly reduced by osthole treatment.	osthol	160-167	interleukin 1 beta	Mus musculus	94-102	
28603288-6	2017	In mouse peritoneal macrophages, pretreatment with osthole (50 mumol/L) significantly attenuated the LPS-induced elevation of cytokines at the mRNA level; inhibition of PKA completely reversed the inhibitory effects of osthole on IL-1beta, IL-6, COX2, and MCP-1 but not on TNFalpha.	osthol	51-58	interleukin 1 beta	Mus musculus	230-238	
28603288-8	2017	Moreover, in LPS-stimulated mouse peritoneal macrophages, SB203580 strongly inhibited the restored expression of IL-1beta, IL-6, COX2, and MCP-1, which was achieved by abolishing the suppressive effects of osthole with the PKA inhibitors.	osthol	206-213	interleukin 1 beta	Mus musculus	113-121	
27902475-8	2017	Furthermore, osthole can suppress NF-kappaB signal pathway through the inhibition of the nuclear translocation by regulating phosphorylation of IkappaBalpha and IKKbeta and hinder the production of chemoattractant (MCP-1 and IL-8) and proinflammatory cytokines (TNF-alpha, IL-1beta and IL-6).	osthol	13-20	interleukin 1 beta	Mus musculus	273-281