PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9492297-6 1998 Using the lysosomotropic agent NH4Cl and the vesicularization inhibitor brefeldin A, we show here the convergence of TNF-alpha-induced death signaling on an acidic, subcellular compartment reminiscent of lysosomes. Ammonium Chloride 31-36 tumor necrosis factor Homo sapiens 117-126 11849318-8 2002 Other weak-base amines, including hydroxychloroquine, ammonium chloride and methylamine, also induced reduction of cell surface TNF receptors, whereas lysosomal proteinase inhibitor, leupeptin, and BB-3013 were without effect. Ammonium Chloride 54-71 tumor necrosis factor Homo sapiens 128-131 27655254-5 2017 NH4Cl (5 mmol/l) had no effect on LPS-induced upregulation of CD14, IL-1alpha/beta and IL-6 mRNA but enhanced LPS-induced upregulation of TNF-alpha mRNA in mono-cultured microglia. Ammonium Chloride 0-5 tumor necrosis factor Homo sapiens 138-147 16541468-7 2006 We observed that ammonium chloride and tunicamycin blocked TNF-alpha-EGFP fusion protein delivery to secretory granules. Ammonium Chloride 17-34 tumor necrosis factor Homo sapiens 59-68 11058554-11 2000 The LDH(A4) activity stimulated by TNFalpha was decreased by 36.2% by an inhibitor of sphingosine formation, NH4Cl (4 mM), supporting a role of sphingosine in the TNFalpha effect. Ammonium Chloride 109-114 tumor necrosis factor Homo sapiens 35-43 11058554-11 2000 The LDH(A4) activity stimulated by TNFalpha was decreased by 36.2% by an inhibitor of sphingosine formation, NH4Cl (4 mM), supporting a role of sphingosine in the TNFalpha effect. Ammonium Chloride 109-114 tumor necrosis factor Homo sapiens 163-171 7948429-7 1994 PMA-induced down-regulation of receptors was not dependent on acidity as it occurred also in the presence of monensin and NH4Cl when the release of TNF-BPs is partially blocked. Ammonium Chloride 122-127 tumor necrosis factor Homo sapiens 148-151 2370113-5 1990 When NH4Cl-treated cells were exposed to TNF at low pH, the level of killing increased two- to threefold over that attained with cells maintained at neutral pH (either with or without NH4Cl). Ammonium Chloride 5-10 tumor necrosis factor Homo sapiens 41-44 2370113-5 1990 When NH4Cl-treated cells were exposed to TNF at low pH, the level of killing increased two- to threefold over that attained with cells maintained at neutral pH (either with or without NH4Cl). Ammonium Chloride 184-189 tumor necrosis factor Homo sapiens 41-44