PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3157989-2 1985 Preincubation of platelets with 10 mM NH4Cl for up to 2 hr resulted in a time-dependent and marked stimulation of thrombin-induced secretion of both this enzyme and other acid glycosidases from platelets. Ammonium Chloride 38-43 coagulation factor II, thrombin Homo sapiens 114-122 7810595-7 1994 Cytosolic alkalinization by monensin or NH4Cl enhanced thrombin, ADP, and thimerosal-induced external Ca2+ entry. Ammonium Chloride 40-45 coagulation factor II, thrombin Homo sapiens 55-63 2831223-3 1988 Several observations indicate that the exchanger is regulated by protein kinase C. (i) Inhibitors of protein kinase C (trifluoperazine, sphingosine) inhibit the increase in pHi seen during thrombin stimulation as well as Ca2+ mobilization; artificially increasing pHi by monensin or NH4Cl then restores Ca2+ mobilization. Ammonium Chloride 283-288 coagulation factor II, thrombin Homo sapiens 189-197 2546795-5 1989 Thus, (i) NH4Cl, which restored the increase in [pH]i in the absence of [Na+]e reduced the potentiated secretory response to thrombin, (ii) no increase in thrombin-induced secretion was observed when Na+ was replaced with Li+, which allowed a normal increase in [pH]i and (iii) ethyl isopropyl amiloride (EIPA) abolished the [pH]i rise and potentiated thrombin-induced secretion. Ammonium Chloride 10-15 coagulation factor II, thrombin Homo sapiens 125-133 3157989-7 1985 Thrombin-induced secretion of adenine nucleotides from dense granules and of beta-thromboglobulin from alpha granules was slightly enhanced by NH4Cl but was slightly inhibited by methylamine. Ammonium Chloride 143-148 coagulation factor II, thrombin Homo sapiens 0-8